AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication

Hori, Kei; Yamashiro, Kunihiko; Nagai, Taku; Shan, Wei; Egusa, Saki F.; Shimaoka, Kazumi; Kuniishi, Hiroshi; Sekiguchi, Masayuki; Go, Yasuhiro; Tatsumoto, Shoji; Yamada, Mitsuyo; Shiraishi, Reika; Kanno, Kouta; Miyashita, Satoshi; Sakamoto, Asami; Abe, Manabu; Sakimura, Kenji; Sone, Masaki; Sohya, Kazuhiro; Wada, Keiji; Yamada, Mitsuhiko; Yamada, Kiyofumi; Hoshino, Mikio

doi:10.1016/j.isci.2020.101183

Cited by 40 publications

(79 citation statements)

References 82 publications

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“…By contrast, the number of USVs min −1 reported in other studies, including our previous study, is higher. For example, the mean number of approximately 250 min −1 [ 9 , 24 , 37 ] or approximately 100–150 min −1 [ 25 , 28 ] of male–female USVs, and approximately 150–200 min −1 of female–female USVs have also been reported [ 25 , 28 ]. In these studies, several days (up to 7 days) of single housing was carried out in both male and female subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, vocal communication in mice has received considerable academic attention because of its power and utility in the investigation of molecular and neural mechanisms for social behaviours and their deficits, especially focusing on developmental disorders such as autism spectrum disorders [ 3 , 22 , 23 ]. For instance, in our previous study, mice carrying a mutation in the autism susceptibility candidate 2 (AUTS2) gene show an increase in excitatory synaptic inputs in the forebrain, as well as a reduction in their social interaction and vocalizations toward unfamiliar individuals [ 24 ]. Therefore, using both male and female mice, we aimed to observe alterations in USVs depending on different social contexts such as familiarity with social partners.…”

Section: Introductionmentioning

confidence: 99%

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Sex differences in vocalizations to familiar or unfamiliar females in mice

2020

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Mice, both wild and laboratory strains, emit ultrasound to communicate. The sex differences between male to female (male–female) and female to female (female–female) ultrasonic vocalizations (USVs) have been discussed for decades. In the present study, we compared the number of USVs emitted to familiar and unfamiliar females by both males (male–female USVs) and females (female–female USVs). We found that females vocalized more to unfamiliar than to familiar females. By contrast, males exhibited more USVs to familiar partners. This sexually dimorphic behaviour suggests that mice change their vocal behaviour in response to the social context, and their perception of the context is based on social cognition and memory. In addition, because males vocalized more to familiar females, USVs appear to be not only a response to novel objects or individuals, but also a social response.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex differences in vocalizations to familiar or unfamiliar females in mice

2020

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“…For example, the mean number of approximately 250 / min (Kikusui et al, 2011;Kanno and Kikusui, 2018;Hori et al, 2020) or approximately 100-150 / min (Hammerschmidt et al, 2012;Ey et al, 2013) of male-female USVs, and approximately 150-200 / min of female-female USVs have also been reported (Hammerschmidt et al, 2012;Ey et al, 2013). In these studies, several days (up to 7 days) of single housing was carried out in both male and female subjects.…”

Section: Technical Limitations and Considerations For Experimental Dementioning

confidence: 99%

“…Recently, vocal communication in mice has attracted considerable academic attention because of its power and utility in the investigation of molecular and neural mechanisms for social behaviors and their deficits, especially focusing on developmental disorders such as autism spectrum disorders (Fischer and Hammerschmidt, 2011;Lahvis et al, 2011;Konopka and Roberts, 2016). In addition, we previously investigated synapses and behaviors in the mutants of Autism susceptibility candidate 2 (AUTS2) gene, and we reported that excitatory synaptic inputs were increased in the forebrain and that social interaction and vocalizations were altered in the mice (Hori et al, 2020). In mice, ultrasonic vocalizations (USVs) are used for communication, and they can be widely observed in both wild and laboratory strains (Sales, 2010).…”

Section: Introductionmentioning

confidence: 99%

Sex differences in vocalizations to familiar or unfamiliar females in mice

Sasaki

Tomita

Kanno

2020

Preprint

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1Mice, both wild and laboratory strains, emit ultrasounds to communicate. The 2 sex differences between male to female (male-female) and female to female (female-3 female) ultrasonic vocalizations (USVs) have been discussed for decades. In the present 4 study, we compared the number of USVs emitted to familiar and unfamiliar female by 5 both males (male-female USVs) and females (female-female USVs). We found that 6 females vocalized more to unfamiliar than to familiar females. In contrast, males 7 exhibited more USVs to familiar partners. This sexually dimorphic behavior suggests 8 that mice change their vocal behavior in response to the social context, and their 9 perception of the context is based on social cognition and memory. In addition, because 10 males vocalized more to familiar females, USVs appear to be not just a response to 11 novel things or individuals, but also to be a social response. 12 13 memory 15 16

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“…2. The Auts2 del8/+ pups with C57BL/6N background, which exon 8 of the Auts2 gene has been removed, were generated by Auts2 del8/+ male mice with wildtype female mice as the previous research [31]. After mating, each female mouse was separated from the male mouse.…”

Section: Experimental Animalsmentioning

confidence: 99%

Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice

Mai

Kimura

Hori

et al. 2019

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25Autism Spectrum Disorder (ASD) is one of the neurodevelopmental disorders and 26 characterized with persistent impairments in social communication (including verbal 27 and nonverbal communication) and repetitive behavior together with various 28 comorbid symptoms. Epidemiological studies suggest a significant association 29 between advanced paternal age and incidence of ASD in offspring, which has been 30 modeled in rodents. However, how paternal aging makes an impact on the offspring's 31 early communicative behavior, especially at the individual level, has not been 32 addressed. Here we systematically analyzed postnatal development of vocal 33 communication of pups by measuring ultrasonic vocalization (USV) induced by 34 maternal separation that is considered to correspond to baby's cry, an earliest verbal 35 communication in human. Maternal separation-induced USV of each offspring 36 derived from young (3 months) or aged (>12 months) father was individually 37 measured for 5 minutes at postnatal day 3 (P3), P6, P9, and P12. We classified USV 38 syllables into twelve types according to Scattoni's classification with minor 39 modifications, and analyzed duration, maximum frequency, maximum amplitude and 40 interval of each syllable. Compared between the two groups, the offspring derived 41 from aged fathers emitted the syllables with less number, shorter duration, different 42 syllable components and less diversity. From an individual perspective, offspring 43 derived from young father showed a developmental convergence in vocal 44 communication, while those from aged fathers exhibited atypical developmental 45 patterns. Taken together, we showed for the first time a significant influence of 46 paternal aging on early vocal development with qualitative and quantitative aspects in 47 50 Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by 51 two core symptoms; i.e., social interaction impairment (including verbal and 52 nonverbal communication deficits) and repetitive behavior [1][2][3] . In most cases, the 53 exact etiology of ASD remains unclear, although researchers believe that genetic, 54 environmental and epigenetic factors are involved in the neuropathology of ASD [4][5][6] . 55In recent years, epidemiological studies repeatedly suggest a significant association 56 between paternal aging and a risk of ASD in offspring. Compared with the children of 57 young fathers, the children were more likely to be diagnosed ASD if their fathers 58 were older [7][8][9][10] . Thus, paternal aging can be worth to be focused as one of the 59 non-genetic mechanisms leading to ASD. 60 61In the new criteria of DSM-5, the communication and social interaction parts are 62 combined into one, i.e., "Social/Communication Deficits". This modification 63 emphasizes the importance of the social communication domain in ASD in early 64 infancy. Human infant crying is an innate social communication [11, 12] , which has a 65 natural peak in frequency of approximately 2.5 hours of crying per day at aroun...

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AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication

Cited by 40 publications

References 82 publications

Sex differences in vocalizations to familiar or unfamiliar females in mice

Sex differences in vocalizations to familiar or unfamiliar females in mice

Sex differences in vocalizations to familiar or unfamiliar females in mice

Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice

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