AUTS2, a causative gene for microcephaly, regulates division of intermediate progenitor cells and production of upper-layer neurons
Kazumi Shimaoka,
Kei Hori,
Satoshi Miyashita
et al.
Abstract:AUTS2 mutations often exhibit neurodevelopmental disorders and microcephaly. However, how AUTS2 regulates neuron production and affects brain size remains unclear. Here, we show that AUTS2 cooperates with the Polycomb complex PRC2 to regulate gene expression and cortical neurogenesis. Auts2 mutant mice exhibit reduced division of intermediate progenitor cells (IPCs), leading to decreased neurons and thickness in the upper-layer cortex. Expression of Robo1 is increased in the mutants, which in turn suppresses I… Show more
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