Autoxidation-Resistant, ROS-Scavenging, and Anti-Inflammatory Micellar Nanoparticles Self-Assembled from Poly(acrylic acid)–Green Tea Catechin Conjugates

Bae, Ki Hyun; Chan, Kiat Hwa; Kurisawa, Motoichi

doi:10.1021/acsmacrolett.2c00239

Cited by 12 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…solution (Figure 5A). 111 Shen et al conjugated Quercetin to glycol chitosan via an aryl boronic ester linkage, leading to the formation of GC-B-Que micelles in water (Figure 5B). 40 Reproduced with permission.…”

Section: Self-assembly Of Polyphenol-grafted Polymersmentioning

confidence: 99%

“…Bae et al conjugated EGCG to poly(acrylic acid) (PAA) through a cysteamine linkage, resulting in the formation of PAA‐EGCG, which self‐assembled into micellar nanoparticles in an aqueous solution (Figure 5A). 111 Shen et al conjugated Quercetin to glycol chitosan via an aryl boronic ester linkage, leading to the formation of GC‐B‐Que micelles in water (Figure 5B). 40 Payra et al modified the hydrophilic TA with n‐alkyl chains, yielding TA‐based multiarm surfactants that self‐assembled into size‐tunable spherical vesicles ranging in size from 0.1 to 1.0 μm (Figure 5C–E).…”

Section: Engineering Polyphenol‐based Assembliesmentioning

confidence: 99%

Section: Engineering Polyphenol‐based Assembliesmentioning

confidence: 99%

See 2 more Smart Citations

Assembled polyphenol‐based systems as advanced therapeutics

Liu,

Pan,

Shi

et al. 2023

Journal of Polymer Science

View full text Add to dashboard Cite

Polymeric assemblies have emerged as a kind of promising platform in biomedical fields. The strong potency of polyphenols to form versatile interactions with other small or polymeric molecules via covalent and noncovalent linkages enables polyphenols to serve as molecular glues, offering a magic driving force to assemble multiple functional molecules into a diversity of polyphenol‐based systems, such as nanoparticles and hydrogels. Due to the unique merits of anti‐tumor, anti‐bacterial, antioxidant, anti‐inflammatory, and cardioprotective properties of polyphenols, polyphenol‐based systems hold great promise to deal with a wide spectrum of diseases. This review comprehensively overviews the components, intermolecular interactions, and preparation methods implicated in the assembly of polyphenol‐based systems. In addition, their medical applications are introduced, particularly the treatments of various diseases, such as tumors, bacterial infections, inflammatory bowel disease (IBD), cardiovascular diseases (CVDs), chronic periodontitis, acute lung injury, osteoarthritis, and renal fibrosis.

show abstract

Section: Self-assembly Of Polyphenol-grafted Polymersmentioning

confidence: 99%

Section: Engineering Polyphenol‐based Assembliesmentioning

confidence: 99%

See 1 more Smart Citation

Assembled polyphenol‐based systems as advanced therapeutics

Liu,

Pan,

Shi

et al. 2023

Journal of Polymer Science

View full text Add to dashboard Cite

show abstract

Two Birds with One Stone: Guanidyl Carbon Dots with Enhanced Antioxidative and Lipolytic Functions in Metabolic Associated Fatty Liver

Cai,

Li,

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Metabolic‐associated fatty liver disease (MAFLD) has become one of the most widespread metabolic diseases nowadays, while no definitive agent is approved for practical treatment. Given excessive lipid deposition and cellular oxidative stress are two main inducers of MAFLD, developing synergistic therapeutic agents that enhance lipid metabolism and antioxidative ability are effective routes for MAFLD therapy. Herein, a novel kind of bio‐functional carbon dots (MTCDs) derived from metformin and tea polyphenols based on a fused pharmacophore strategy is developed. The surface of MTCDs retains abundant phenolic hydroxyl and guanidine groups, which are designed to reduce both lipid deposition and oxidative stress in the liver. Moreover, by finely controlling the surface charge, MTCDs exhibit excellent lysosome targeting functionality with favorable biocompatibility and low biotoxicity. Mechanistical studies further reveal that MTCDs treatment protects lysosomes from oxidative stress damage and activates hepatocyte AMP‐activated protein kinase signaling, which initiates lipophagy progress to accelerate lipolysis and lipid consumption. Collectively, these studies propose an effective “two birds with one stone” tool for MAFLD synergistic therapy and suggest a viable strategy for multi‐pharmacophore agent development.

show abstract

Nanotechnology‐Mediated Immunomodulation Strategy for Inflammation Resolution

Li,

Liu,

Wang

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Inflammation serves as a common characteristic across a wide range of diseases and plays a vital role in maintaining homeostasis. Inflammation can lead to tissue damage and the onset of inflammatory diseases. Although significant progress is made in anti‐inflammation in recent years, the current clinical approaches mainly rely on the systemic administration of corticosteroids and antibiotics, which only provide short‐term relief. Recently, immunomodulatory approaches have emerged as promising strategies for facilitating the resolution of inflammation. Especially, the advanced nanosystems with unique biocompatibility and multifunctionality have provided an ideal platform for immunomodulation. In this review, the pathophysiology of inflammation and current therapeutic strategies are summarized. It is mainly focused on the nanomedicines that modulate the inflammatory signaling pathways, inflammatory cells, oxidative stress, and inflammation targeting. Finally, the challenges and opportunities of nanomaterials in addressing inflammation are also discussed. The nanotechnology‐mediated immunomodulation will open a new treatment strategy for inflammation therapy.

show abstract

Autoxidation-Resistant, ROS-Scavenging, and Anti-Inflammatory Micellar Nanoparticles Self-Assembled from Poly(acrylic acid)–Green Tea Catechin Conjugates

Cited by 12 publications

References 37 publications

Assembled polyphenol‐based systems as advanced therapeutics

Assembled polyphenol‐based systems as advanced therapeutics

Two Birds with One Stone: Guanidyl Carbon Dots with Enhanced Antioxidative and Lipolytic Functions in Metabolic Associated Fatty Liver

Nanotechnology‐Mediated Immunomodulation Strategy for Inflammation Resolution

Contact Info

Product

Resources

About