Autoxidation of linalyl acetate, the main component of lavender oil, creates potent contact allergens

Abstract

It is concluded that autoxidation of the weakly allergenic linalyl acetate leads to formation of allergenic oxidation products.

A sensitive method for determination of allergenic fragrance terpene hydroperoxides using liquid chromatography coupled with tandem mass spectrometry

“…1 H-and 13 C-NMR data of LinOOH 1, and LinOAcOOH 2 (both in a 5:3 ratio of tertiary hydroperoxide/secondary hydroperoxide) and LimOOH 3 agree with literature data [16,23,24].…”

“…The monoterpenes were purified by distillation (≥97% according to GC/MS) before use. The hydroperoxides were synthesized and purified according to earlier experience [16,23,24]. Identity and purity of the analytes were examined with NMR (>96% purity), and the data agreed with published reports.…”

Phytochemical Screening and Antimicrobial Evaluation of Syzygium aromaticum Extract and Essential oil

“…molecular structures (presence of olefenic double bonds and functional groups such as hydroxyl, aldehyde, ester); essential oils are readily oxidizable by light, heat and air. (Skold et al, 2008).…”

The Therapeutic Benefits of Essential Oils

“…Essential oils are hydrophobic, are soluble in alcohol, non polar or weakly polar solvents, waxes and oils, but only slightly soluble in water and most are colourless or pale yellow, with exception of the blue essential oil of chamomile (Matricaria chamomilla) and most are liquid and of lower density than water (sassafras, vetiver, cinnamon and clove essential oils being exceptions) (Gupta et al, 2010;Martín et al, 2010). Due to their molecular structures (presence of olefenic double bonds and functional groups such as hydroxyl, aldehyde, ester); essential oils are readily oxidizable by light, heat and air (Skold et al, 2006;Skold et al, 2008). Some examples of oxidations are illustrated in figure 1.…”