Autotransplantation of cryopreserved ovarian tissue in 12 women with chemotherapy-induced premature ovarian failure: the Danish experience

Schmidt, Kirsten Tryde; Rosendahl, Mikkel; Ernst, Erik; Loft, Anne; Andersen, Anders Nyboe; Dueholm, Margit; Ottosen, Christian; Andersen, Claus Yding

doi:10.1016/j.fertnstert.2010.07.1080

Cited by 109 publications

(87 citation statements)

References 43 publications

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“…Few experimental studies have tested the human ovarian tissue from both HL or NHL and failed to show evidence of ovarian involvement by lymphoma cells [18,20,24,25]. To date, 15 auto-transplantations have been reported in HL patients and 6 in NHL without any disease recurrence, knowing that the follow-up after autotransplantation in one of the HL patients is now up to 8 years [19,[26][27][28][29][30][31][32][33][34]. Nevertheless, a recent case-report showed an ovarian involvement in the histologic examination of ovarian cortex pieces in a stage III HL [15].…”

Section: Discussionmentioning

confidence: 99%

Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

Gronier

Terriou

Robin

et al. 2014

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 99%

Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

Gronier

Terriou

Robin

et al. 2014

J Assist Reprod Genet

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“…After a 5 h transport on ice in culture medium the ovary was dissected into 29 pieces of cortex and cryopreserved as previously described [4]. In brief, the cortical tissue was cut into 1-2 mm thickness and a size of approximately 5× 5 mm.…”

Section: Case Reportmentioning

confidence: 99%

“…In brief, the cortical tissue was cut into 1-2 mm thickness and a size of approximately 5× 5 mm. The tissue was cryo-stored in a mixture of cryoprotectants containing ethyleneglycerol, sucrose and human serum albumin [4,9]. There was performed no histological assessment of the tissue prior to cryopreservation, nor was it transplanted to immunedeficient mice.…”

Section: Case Reportmentioning

confidence: 99%

“…The patients' cryopreserved tissue was thawed and transplanted as previously described [4]. In brief, the in situ ovary was extracted from the peritoneal cavity using laparoscopy.…”

Section: Case Reportmentioning

confidence: 99%

“…This technique has shown promising results in both women and children [3][4][5] and is the only fertility preserving opportunity available for patients who cannot delay the start of chemotherapy and for young prepubertal girls [6]. Currently a total of more than 20 healthy children have been born following transplantation of frozen/thawed ovarian tissue, without one single case of cancer relapse due to the transplantation of ovarian tissue [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Legal termination of a pregnancy resulting from transplanted cryopreserved ovarian tissue due to cancer recurrence

Ernst

Offersen

Andersen

et al. 2013

J Assist Reprod Genet

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Purpose To report on a woman who conceived naturally and had a normal intrauterine pregnancy following transplantation of frozen/thawed ovarian tissue but decided to have an early abortion due to recurrence of breast cancer. Methods The patient was diagnosed breast cancer and received antineoplastic treatment that forced her into premature ovarian insufficiency and infertility. Ovarian tissue cryopreserved prior to chemotherapy was transplanted following cancer treatment restoring fertility and regular menstrual cycles.Results The patient conceived 6 month after transplantation. However, she experienced recurrence of breast cancer and decided on legal termination of the pregnancy in the first trimester. DiscussionThe obtained pregnancy only 6 month following transplantation underlines the ability of the procedure. The recurrence occurred near the original site of the tumor and was most unlikely related to the transplantation. The activity of the transplanted tissue is likely to be destroyed by the renewed antineoplastic treatment she will receive. However, she still has the majority of one ovary cryostored and may later want to undergo additional transplantation to regain fertility or to have menstrual cycles back.

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Clinical images: Otitis media and nasal granulation in Wegener's granulomatosis

Nagato¹,

Otaka²,

Wada³

et al. 2009

Arthritis & Rheumatism

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Autotransplantation of cryopreserved ovarian tissue in 12 women with chemotherapy-induced premature ovarian failure: the Danish experience

Cited by 109 publications

References 43 publications

Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

Legal termination of a pregnancy resulting from transplanted cryopreserved ovarian tissue due to cancer recurrence

Clinical images: Otitis media and nasal granulation in Wegener's granulomatosis

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