Autotopes and Allotopes

Kashtan, Clifford E.

doi:10.1681/asn.2005090943

Cited by 2 publications

(2 citation statements)

References 22 publications

(17 reference statements)

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“…The nature of the immune responses which lead to GN, and the individuals who develop them, are strongly influenced by immunogenetic phenotypes. It is likely that most precipitating factors of all GN initiate similar immune responses that result in GN via shared common pathways (3). Moreover, in the initial stages, all GN are characterized by an inflammatory process mediated by a number of soluble factors (cytokines, chemokines, growth factors, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…It is likely that most precipitating factors of all GN initiate similar immune responses that *These authors contributed to this study equally. result in GN via shared common pathways (3). Moreover, in the initial stages, all GN are characterized by an inflammatory process mediated by a number of soluble factors (cytokines, chemokines, growth factors, etc.)…”

Section: Introductionmentioning

confidence: 99%

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Interleukin-18, transforming growth factor-β, and vascular endothelial growth factor gene polymorphisms and susceptibility to primary glomerulonephritis

et al. 2010

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Several studies have showed an association of gene polymorphisms with the development of glomerulonephritis (GN). We investigated the effects of gene polymorphisms on the development of GN by analyzing polymorphisms in the interleukin (IL)-18, transforming growth factor (TGF)-β, and vascular endothelial growth factor (VEGF) genes in Korean patients with primary GN. The study included 146 normal subjects (controls) and 100 patients diagnosed with primary GN by kidney biopsy. The gene polymorphisms A-607C and G-137C in IL-18, C-509T and T869C in TGF-β1, and C-2578A and C405G in VEGF were investigated in DNA extracted from peripheral blood. Significant differences were observed between the GN and control groups in the genotype and allele frequencies of A-607C IL-18 and C405G VEGF. The frequencies of the IL-18-607CC genotype [P = 0.001, odds ratio (OR) = 2.473] and the VEGF 405GG genotype (P = 0.001, OR = 2.473) were significantly increased in the GN group. The combination of IL-18-607CC+ and VEGF 405GG+ genotypes had a higher risk for developing GN in comparison with the combination of IL-18-607CC- and VEGF 405GG- genotypes (P < 0.001, OR = 8.642). In the haplotype analysis of the IL-18 gene, the CG haplotype was significantly more frequent in the GN group than the control group (61.5% vs 46.9%, P = 0.002). These results show that the -607CC genotype of the IL-18 gene and the 405GG genotype of the VEGF gene are associated with susceptibility to and the development of primary GN.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%