Autosplenectomy and antiphospholipid antibodies in systemic lupus erythematosus: a pathogenetic relationship?

The diagnosis and management of the haematologic manifestations of lupus

“…It may occur as a result of active disease or reactive to the underlying inflammatory process. Hyposplenism (or functional aesplenia or autosplenectomy) has been reported as a cause of thrombocytosis in SLE patients [154,155] and may be related with aPL or with associated APS [156,157].…”

Severe infection with encapsulated bacteria as the initial presentation of systemic lupus erythematosus: two case reports and a review of the literature.

“…Other encapsulated organisms (particularly S. pneumoniae) are also frequently seen, reflecting potential chemotaxis and opsonization defects, splenic dysfunction and hypocomplementaemia (Petri, 1998). Splenic dysfunction has been reported to occur in 5 % of SLE patients, and may be due to a variety of aetiologies including circulating immune complexes, and impairment of splenic circulation due to vasculitis or thrombotic events (Santilli et al, 2003). SLE patients without functioning spleens are at especially high risk for severe infection, most commonly due to S. pneumoniae (Santilli et al, 2003).…”

“…Splenic dysfunction has been reported to occur in 5 % of SLE patients, and may be due to a variety of aetiologies including circulating immune complexes, and impairment of splenic circulation due to vasculitis or thrombotic events (Santilli et al, 2003). SLE patients without functioning spleens are at especially high risk for severe infection, most commonly due to S. pneumoniae (Santilli et al, 2003). While no formal splenic function testing was performed on our case patients to confirm that they had fully functioning spleens, both had normal-appearing spleens on imaging and no Howell-Jolly bodies were seen on blood smears.…”

Acute Complete Splenic Infarction in a Patient with Hirschsprung’s Disease and Literature Review of Complete Splenic Infarction

“…Ultrasonography of the spleen reported as heterogenic hypoechoic and granulomatous areas. commonly seen in sickle cell disease, but there are also reports in systemic lupus erythematosus in about 5% [9,10] , after bone marrow transplantation [11] and Rothmann-Makai syndrome (lipogranulomatosis subcutanea) [12] . Viscomi et al [13] described massive splenic infarction due to Trichosporon beigelii infiltration of the spleen.…”