Autosomal polymorphism in laboratory bred and wild Norway rats, Rattus norvegicus, found in Misima

Yosida, Tosihide H.; Amano, Kohachi

doi:10.1007/bf00285115

Cited by 151 publications

(77 citation statements)

References 16 publications

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“…Bone-marrow was extracted from femur bone and metaphases according to the method of Yosida and Amano (1965). The preparations of mitotic chromosome were made according to Ford and Hamerton (1956).…”

Section: Cytogenetical Studymentioning

confidence: 99%

The protective role of honey against cytotoxicity of cadmium chloride in mice

Shahrour¹,

Zowail²,

Sharafeldin³

2016

Afr. J. Biotechnol.

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The present study aimed to investigate the honey (HY) protective role in opposition to cadmium (Cd) induced chromosomal aberrations of bone marrow and sperm abnormalities. Forty five (45) adult male albino mice were caged into six groups. Mice were injected, i.p, 300 mg HY/kg and/or 0.67 mg CdCl 2 /kg b.w for 96 h, separately and alternated. The alternated trials were continued for consecutive eight days. Results show that mice injected with cadmium had significant increase in the frequency of aberrant chromosomes as fragment, centric fusion, gap, stickiness and aneuploidy and in sperm abnormality. The administration of HY improved the frequency of the chromosomal aberrations and sperm abnormality induced by Cd.

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Section: Cytogenetical Studymentioning

confidence: 99%

The protective role of honey against cytotoxicity of cadmium chloride in mice

Shahrour¹,

Zowail²,

Sharafeldin³

2016

Afr. J. Biotechnol.

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“…At the end of the time of drug administration, all animals were injected IP with a colchicine solution. Two hours later, the animals were sacrificed by cervical dislocation and the chromosomes Toxicity of anthelmintic drug oxfendazole residues 141 of bone marrow cells and spermatocytes were prepared according to Yosida and Amano [9], Brewen and Preston [10].…”

Section: Assay Of Genotoxicity In Malesmentioning

confidence: 99%

“…The chromosomes of bone marrow cells of pregnant females were prepared by using the methodology of Yosida and Amano [9] and the chromosomes of fetal cells were prepared according to the method of Romagnano et al [13].…”

Section: Chromosome Preparationmentioning

confidence: 99%

Genotoxical, teratological and biochemical effects of anthelmintic drug oxfendazole Maximum Residue Limit (MRL) in male and female mice

et al. 2006

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-Oxfendazole, methyl-5 (6)-phenylsulfinyl-2-benzimidazole carbamate, is a member of the benzimidazole family of anthelmintics. Anthelmintic benzimidazoles are widely used in meat producing animals (cattle, sheep and pigs) for control of endoparasites. The extensive use of veterinary drugs in food-producing animals can cause the presence of small quantities of the drug residues in food. Maximum residue limit or "MRL" means the maximum concentration of residue resulting from the use of a veterinary medicinal product which may be legally permitted recognized as acceptable in food. The FAO/WHO Expert Committee on Food Additives (1999) evaluations of toxicological and residue data, reported that oxfendazole (MRL) has toxicological hazards on human health. The toxicity of oxfendazole (MRL) was tested in male and female mice and their fetuses. Chromosomal aberrations, teratological examination and biochemical analysis were the parameters used in this study. The results show that oxfendazole MRL induced a mutagenic effect in all tested cell types. Also, oxfendazole exhibit embryotoxicity including teratogenicity. The biochemical results show that oxfendazole induced a disturbance in the different biochemical contents of all tested tissues. So, we must increase the attention paid to the potential risk of oxfendazole residues in human beings and should stress the need for careful control to ensure adherence to the prescribed withdrawal time of this drug.anthelmintic / oxfendazole / maximum residue limit / genotoxicity / embryotoxicity / teratogenicity / biochemical changes

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“…Except for a small inversion of pair no. 3 (Yosida and Amano 1965), no remarkable alteration has been referred to in the literature.…”

mentioning

confidence: 97%