Autoregulation retinaler Arteriolen bei Patienten mit Diabetes mellitus und Normalprobanden*

Blum, Marcus; Kubetschka, Ulrich; Hunger-Dathe, Wilgard; Bachmann, K. J.; Müller, Ulrich A.; Strobel, Jürgen

doi:10.1055/s-2000-10514

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…Auch systemische Erkrankungen wie z. B. Auswirkungen der systemischen Hypertension oder des Diabetes mellitus [5,19] sowie ihre Veränderungen durch therapeutische Maûnahmen sind als Anwendungsgebiete für derartige funktionelle, dynamische Messungen denkbar.…”

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Reaktion retinaler Gefäßdurchmesser auf 100 % O2-Atmung - funktionelle Messung mit dem Retinal Vessel Analyzer an 10 Probanden1

Lanzl¹,

Witta²,

Kotliar³

et al. 2000

Klin Monatsbl Augenheilkd

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RVA allows assessment of functional retinal branch vessel reactions. Retinal branch vessels diameters are denominators for capillary perfusion. RVA might be able to demonstrate an individual vessel's regulation potential by purposeful stimulation to constrict and dilate. This property could be helpful in understanding pathophysiologic processes as well as improving diagnosis and therapeutic effects in diseases influencing ocular perfusion such as diabetes, retinal vessel occlusion or even glaucoma. Further evaluation of effects of systemic diseases might be an additional application of functional retinal vessel diameter assessment by RVA.

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unclassified

Reaktion retinaler Gefäßdurchmesser auf 100 % O2-Atmung - funktionelle Messung mit dem Retinal Vessel Analyzer an 10 Probanden1

Lanzl¹,

Witta²,

Kotliar³

et al. 2000

Klin Monatsbl Augenheilkd

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“…Estimation of autoregulation ränge (dilation reserve and constriction reserve) in different autoregulative Systems has a very high potential to indicate vascular risk factors, early involvement of functional changes and disturbances of microcirculation äs shown by the IOP provocation Stimulus. Other studies demonstrate [4] that autoregulation ability to constrict against blood pressure rise is reduced in advanced age and diabetic angiopathy. Similar results are obtained by means of RVA [3] when breathing 100% oxygen.…”

Section: Discussionmentioning

confidence: 97%

Retinal Vessel Analysis - New Possibilities

Vilser¹,

Nagel²,

Lanzl³

2002

Biomedizinische Technik/Biomedical Engineering

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Retinal Vessel Analysis is a new technique to assess behavior of large retinal vessels based on diameter measurements. The Retinal Vessel Analyzer (RVA) measures continuously on-line obtaining data in relation to time and local position. Possible analysis tools include (a) Time Course Analysis of physiological, pathological, or therapy induced changes; (b) Local Course Analysis to recognize local narrow or wide vessel segments along the vessel; (c) Vasomotoric Analysis to determine vasomotions and blood pressure related diameter changes; (d) Functional Analysis to examine dynamic behavior e.g. the ability to autoregulate and (e) Functional Imaging to visualize functional parameters of vessels in single vessel segments. RVA is thus able to recognize and study different autoregulation mechanisms.

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“…Measurements can be started by a mouse click, and the diameter of the column of red blood cells was measured by the contrast from wall to wall, which is defined as vessel width. The mean vessel diameter during phase I was used as a baseline to calculate the resulting percentage change in vessel diameter [3, 9, 10]. …”

Section: Methodsmentioning

confidence: 99%

Improved Metabolic Control Results in Better Myogenic Response of Retinal Arterioles in Patients with Diabetes Mellitus Type 1

Blum

Kloos²,

Gunther³

et al. 2008

Ophthalmologica

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Aims: The retina is protected against high blood pressure by the myogenic constriction of arterioles (the Bayliss effect). Hyperglycemia impairs this retinal autoregulation by endothelial dysfunction. The purpose of this prospective pilot study was to test whether improved metabolic control results in a measurable effect on the myogenic response of human retinal arterioles to acute increases in blood pressure. Methods: The Bayliss effect was measured in 25 patients with diabetes mellitus by the Retinal Vessel Analyzer (RVA), both before and after participation in a treatment and teaching program for intensified insulin therapy with the goal of improved metabolic control. After 12 months, 17 subjects still fulfilled the inclusion criteria and underwent an identical measurement. The Wilcoxon test was used for statistical analysis. Results: During the first session, a rise in mean arterial pressure (MAP) of 20.2 ± 8.6 mm Hg was followed by an arterial vasoconstriction of –3.2 ± 2.9%. The educational program resulted in a significant drop in Hb_A1c levels (9.4 ± 1.9 vs. 6.9 ± 0.98%). Eight subjects did not meet the inclusion criteria after 12 months. Seventeen subjects were remeasured and a rise in blood pressure of 19.5 ± 9.9 mm Hg in the second session was associated with a significantly improved arterial vasoconstriction of –5.9 ± 2.7% (session I vs. session II, p = 0.006). Conclusion: The myogenic response of the arterial wall in human retinal arterioles was significantly improved by the therapeutic intervention.

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Autoregulation retinaler Arteriolen bei Patienten mit Diabetes mellitus und Normalprobanden*

Cited by 12 publications

References 12 publications

Reaktion retinaler Gefäßdurchmesser auf 100 % O2-Atmung - funktionelle Messung mit dem Retinal Vessel Analyzer an 10 Probanden1

Reaktion retinaler Gefäßdurchmesser auf 100 % O2-Atmung - funktionelle Messung mit dem Retinal Vessel Analyzer an 10 Probanden1

Retinal Vessel Analysis - New Possibilities

Improved Metabolic Control Results in Better Myogenic Response of Retinal Arterioles in Patients with Diabetes Mellitus Type 1

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