Autoregulation of Optic Nerve Head Blood Flow Induced by Elevated Intraocular Pressure during Vitreous Surgery

Abstract

The ONH blood flow in subjects without systemic disorders was initially lower, but began to recover 5-10 minutes after a 15 mmHg elevation in IOP. These results indicate that autoregulatory mechanisms of ONH blood flow may help to minimize the effects of IOP elevations and fluctuations during vitreous surgery.

Optic nerve head blood flow regulation during changes in arterial blood pressure in patients with primary open‐angle glaucoma

“…; Hashimoto et al. ,b) and thigh‐cuff release (Ikemura et al. ) has been used to decrease OPP in humans.…”

Comparison of Optic Nerve Head Blood Flow Autoregulation among Quadrants Induced by Decreased Ocular Perfusion Pressure during Vitrectomy

“…The subjects in the present study comprised a subset of 18 eyes of 18 patients of a previously published manuscript [ 19 ]. Seventeen eyes had an idiopathic epiretinal membrane and seven eyes had a macular hole.…”

“…The experimental protocol has been described in detail in previous studies [ 19 – 21 ]. We induced mydriasis by administering 1-2 drops of 0.5% tropicamide and 0.5% phenylephrine hydrochloride (Mydrin-P ophthalmic solution; Santen Pharmaceutical Co., Ltd., Osaka, Japan).…”

“…We used these measurements for the calculation of mean IOP values. SBP and DBP were measured in the same way as reported previously [ 19 – 21 ].…”

“…Recent studies have shown that the MBR in the ONH measured using LSFG was significantly correlated with actual ONH blood flow measured using the microsphere method in monkey eyes [ 25 ] and using the hydrogen gas clearance method in rabbits [ 26 , 27 ]. Furthermore, LSFG is a useful devise to examine the blood flow in the ONH [ 19 – 27 ], retinal vessels [ 28 – 30 ], and choroid [ 31 – 34 ].…”