Autoregenerative redox nanoparticles as an antioxidant and glycation inhibitor for palliation of diabetic cataracts

Zhou, Yurui; Li, Lu; Li, Shenghui; Li, Shufei; Zhao, Miao; Zhou, Qinghong; Gong, Xiaoqun; Yang, Jin; Chang, Jin

doi:10.1039/c9nr02350j

Cited by 42 publications

(20 citation statements)

References 68 publications

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“…It has been reported that the size and concentration of the gold nanoparticles allowed variations in the total surface area of the colloidal suspensions influencing the extent modification of bovine serum albumin (BSA) with d-ribose [17], while selenium nanoparticles protected structural modifications of proteins during glycation [18]. Similarly, cerium dioxide nanoparticles were able to protect the lens epithelial cells from the damage of oxidative stress by scavenging reactive oxygen species (ROS) and further attenuate α-crystallin glycation by possessing antioxidant and antiglycation properties [19]. In addition, the previous study on ZnO-NPs synthesized from aqueous extract of Aloe vera leaf was found to be a potent antiglycation agent, as they could inhibit the formation of AGEs and protect the protein structure from modification [16].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesized ZnO-NPs from Morus indica Attenuates Methylglyoxal-Induced Protein Glycation and RBC Damage: In-Vitro, In-Vivo and Molecular Docking Study

et al. 2019

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The development of advanced glycation end-products (AGEs) inhibitors is considered to have therapeutic potential in diabetic complications inhibiting the loss of the biomolecular function. In the present study, zinc oxide nanoparticles (ZnO-NPs) were synthesized from aqueous leaf extract of Morus indica and were characterized by various techniques such as ultraviolet (UV)-Vis spectroscopy, Powder X-Ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FT-IR), Scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). Further, the inhibition of AGEs formation after exposure to ZnO-NPs was investigated by in-vitro, in-vivo, and molecular docking studies. Biochemical and histopathological changes after exposure to ZnO-NPs were also studied in streptozotocin-induced diabetic rats. ZnO-NPs showed an absorption peak at 359 nm with a purity of 92.62% and ~6–12 nm in size, which is characteristic of nanoparticles. The images of SEM showed agglomeration of smaller ZnO-NPs and EDS authenticating that the synthesized nanoparticles were without impurities. The biosynthesized ZnO-NPs showed significant inhibition in the formation of AGEs. The particles were effective against methylglyoxal (MGO) mediated glycation of bovine serum albumin (BSA) by inhibiting the formation of AGEs, which was dose-dependent. Further, the presence of MGO resulted in complete damage of biconcave red blood corpuscles (RBCs) to an irregular shape, whereas the morphological changes were prevented when they were treated with ZnO-NPs leading to the prevention of complications caused due to glycation. The administration of ZnO-NPs (100 mg Kg−1) in streptozotocin(STZ)-induced diabetic rats reversed hyperglycemia and significantly improved hepatic enzymes level and renal functionality, also the histopathological studies revealed restoration of kidney and liver damage nearer to normal conditions. Molecular docking of BSA with ZnO-NPs confirms that masking of lysine and arginine residues is one of the possible mechanisms responsible for the potent antiglycation activity of ZnO-NPs. The findings strongly suggest scope for exploring the therapeutic potential of diabetes-related complications.

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Section: Introductionmentioning

confidence: 99%

Biosynthesized ZnO-NPs from Morus indica Attenuates Methylglyoxal-Induced Protein Glycation and RBC Damage: In-Vitro, In-Vivo and Molecular Docking Study

et al. 2019

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“…Bodoki et al, by comparison free lutein or lutein-loaded NPs administered orally or topically in selenite cataract, demonstrated that the severity of lens injury was significantly reduced in rats treated with topical applications of lutein-loaded NPs [22]. Recently, it was demonstrated that in diabetic cataract, autoregenerative redox nanoparticles can act as an antioxidant and glycation inhibitor [23].…”

Section: Resultsmentioning

confidence: 99%

The ocular protective effects of PLGA nanoparticles loaded with lutein, in fat diet Wistar rats, treated with sistemic glucocorticoids

Dinu¹,

Pharmacy²,

Vîrgolici³

et al. 2020

Ro J Med Pract.

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Introduction. The carotene lutein is found in ocular layers and has powerful antioxidant, anti-inflammatory and anticarcinogenic properties. Posterior subcapsular cataract develops after prolonged glucocorticoid use. Poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) is one of the most successfully developed biodegradable polymer used as antioxidant delivery system. The purpose of our study was to evaluate the ocular protective effects of PLGA-NPs loaded with lutein, in Wistar rats, on fat diet, treated with systemic glucocorticoids. Materials and methods. Healty Wistar male rats (n= 25, 12 months aged) were divided in 5 equal groups. the control group (S) with standard diet and no treatment and groups with Prednison treatment (1 mg/kg body weight), with and without PLGA-NPs loaded with lutein (1 mg/kg body weight), fed either with standard or fat diet. The duration of treatment was 6 weeks and it was done by gavaje. The eye examination was done by two ophtalmologists as a blind test and photos of the eyes were made. Serum metabolic parameters were measured. The rats treated with Prednison developed cataract and uveitis and the most severe injured eye was observed in the group with high caloric fat diet and no lutein as a supplement. Also, Prednison treatment produced dysglycaemia and dyslipidemia. The co-administration of lutein as PLGA-NPs with Prednison prevented the lens, retina and choroidal injuries, reduced the increased levels of glycaemia, triglyceridemia and increased the serum total antioxidant capacity. Conclusion. The PLGA lutein nanoparticles assured global eye protection, reducing the ocular side effects of prednison.

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“…[ 172,173 ] However, this review did not find any literature on nanomaterial‐mediated treatments for radiation‐induced ophthalmic diseases. Nevertheless, studies on eye oxidative disease therapy, using nanomaterials through the ROS‐scavenging approach, are readily available [ 174–176 ] and provide good guidance for radiation‐induced eye disease treatments because excess ROS generation is the main cause of eye damage under radiation exposure. For instance, Zheng et al.…”

Section: Discussionmentioning

confidence: 99%

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

Xie

Zhao

Wang

et al. 2021

Adv Healthcare Materials

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Radiation treatments often unfavorably damage neighboring healthy organs and cause a series of radiation sequelae, such as radiation‐induced hematopoietic system diseases, radiation‐induced gastrointestinal diseases, radiation‐induced lung diseases, and radiation‐induced skin diseases. Recently, emerging nanomaterials have exhibited good superiority for these radiation‐induced disease treatments. Given this background, the rational design principle of nanomaterials, which helps to optimize the therapeutic efficiency, has been an increasing need. Consequently, it is of great significance to perform a systematic summarization of the advances in this field, which can trigger the development of new high‐performance nanoradioprotectors with drug efficiency maximization. Herein, this review highlights the advances and perspectives in the rational design of nanomaterials for preventing and treating various common radiation‐induced diseases. Furthermore, the sources, clinical symptoms, and pathogenesis/injury mechanisms of these radiation‐induced diseases will also be introduced. Furthermore, current challenges and directions for future efforts in this field are also discussed.

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Autoregenerative redox nanoparticles as an antioxidant and glycation inhibitor for palliation of diabetic cataracts

Abstract: The autoregenerative redox PEG-PLGA coating CeO2 nanoparticles can effectively protect lens epithelial cells from oxidative stress and restrain α-crystallin glycation and crosslinking, thereby alleviating diabetic cataracts.

Cited by 42 publications

References 68 publications

Biosynthesized ZnO-NPs from Morus indica Attenuates Methylglyoxal-Induced Protein Glycation and RBC Damage: In-Vitro, In-Vivo and Molecular Docking Study

Biosynthesized ZnO-NPs from Morus indica Attenuates Methylglyoxal-Induced Protein Glycation and RBC Damage: In-Vitro, In-Vivo and Molecular Docking Study

The ocular protective effects of PLGA nanoparticles loaded with lutein, in fat diet Wistar rats, treated with sistemic glucocorticoids

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

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