Autoreactive human T cell lines recognizing ribosomal protein L7

Donauer, Johannes; Wochner, Michael; Witte, E.; Peter, Hans‐Hartmut; Schlesier, Michael; Krawinkel, Ulrich

doi:10.1093/intimm/11.2.125

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…RPL7 , ribosomal protein L7, has been established as an autoantigen representing a frequent target for autoantibodies from patients with systemic autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis [28]. The humoral autoimmune response to RPL7 apparently is driven by antigen and is T cell dependent [29]. KCNB2 is a potassium voltage-gated channel expressed in a number of tissues, including gastrointestinal smooth muscle cells [30], [31].…”

Section: Discussionmentioning

confidence: 99%

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

et al. 2012

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Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal microbiota with the host immune system in genetically susceptible individuals. The largest meta-analysis of genome-wide association to date identified 71 CD–susceptibility loci in individuals of European ancestry. An important epidemiological feature of CD is that it is 2–4 times more prevalent among individuals of Ashkenazi Jewish (AJ) descent compared to non-Jewish Europeans (NJ). To explore genetic variation associated with CD in AJs, we conducted a genome-wide association study (GWAS) by combining raw genotype data across 10 AJ cohorts consisting of 907 cases and 2,345 controls in the discovery stage, followed up by a replication study in 971 cases and 2,124 controls. We confirmed genome-wide significant associations of 9 known CD loci in AJs and replicated 3 additional loci with strong signal (p<5×10−6). Novel signals detected among AJs were mapped to chromosomes 5q21.1 (rs7705924, combined p = 2×10−8; combined odds ratio OR = 1.48), 2p15 (rs6545946, p = 7×10−9; OR = 1.16), 8q21.11 (rs12677663, p = 2×10−8; OR = 1.15), 10q26.3 (rs10734105, p = 3×10−8; OR = 1.27), and 11q12.1 (rs11229030, p = 8×10−9; OR = 1.15), implicating biologically plausible candidate genes, including RPL7, CPAMD8, PRG2, and PRG3. In all, the 16 replicated and newly discovered loci, in addition to the three coding NOD2 variants, accounted for 11.2% of the total genetic variance for CD risk in the AJ population. This study demonstrates the complementary value of genetic studies in the Ashkenazim.

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Section: Discussionmentioning

confidence: 99%

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

et al. 2012

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“…Much of the initial work on RPL7 was stimulated by the observation that the protein was an autoantigen in human patients with systemic lupus erythematosus or other autoimmune diseases (Donauer et al, 1999). Down-regulation of rpl7 transcripts occurred in senescent human fibroblasts as compared with presenescent and quiescent cells (Seshadri et al, 1993) whereas DD-PCR revealed that rpl7 was one of several genes up-regulated esophagus squamous cell carcinoma (Kazemi-Noureini et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Cold acclimation-induced up-regulation of the ribosomal protein L7 gene in the freeze tolerant wood frog, Rana sylvatica

Wu¹,

Croos²,

Storey³

2008

Gene

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“…Its role in lupus is discussed in ref. [31]. In Figure 6 we see three, high Betti centrality nodes: RPL7, RPL7A and RPS19.…”

Section: Gibbs-homology Network Graph Showing Both Rps10 and Rps18 Asmentioning

confidence: 95%

Personalized Therapy Design for Systemic Lupus Erythematosus Based on the Analysis of Protein-Protein Interaction Networks

Brant

Rietman

Lakka-Klement³

et al. 2019

Preprint

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We analyzed protein expression data for Lupus patients, which have been obtained from publicly available databases. A combination of systems biology and statistical thermodynamics approaches was used to extract topological properties of the associated protein-protein interaction networks for each of the 291 patients whose samples were used to provide the molecular data. We have concluded that among the many proteins that appear to play critical roles in this pathology, most of them are either ribosomal proteins, ubiquitination pathway proteins or heat shock proteins. We propose some of the proteins identified in this study to be considered for drug targeting.

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Autoreactive human T cell lines recognizing ribosomal protein L7

Cited by 9 publications

References 36 publications

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

Cold acclimation-induced up-regulation of the ribosomal protein L7 gene in the freeze tolerant wood frog, Rana sylvatica

Personalized Therapy Design for Systemic Lupus Erythematosus Based on the Analysis of Protein-Protein Interaction Networks

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