Autoradiolysis of the 2-deoxy-2-[18F]fluoro-D-glucose radiopharmaceutical

Buriova, E.; Macášek, F.; Melichar, F.; Kropacek, M.; Procházka, Lukáš

doi:10.1007/s10967-005-0759-9

Cited by 14 publications

(8 citation statements)

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“…Molecules of a PET probe undergo irradiation from both the starting [ 18 F]fluoride (external radiolysis) and from other radiolabeled molecules (autoradiolysis) [28][29][30], which can lead to reduction in the yield of the probe and the formation of radioactive side products. The mechanism of damage is believed to be related to the formation of radical species in the solvent by high-energy particles [29].…”

Section: Reduced Radiolysismentioning

confidence: 99%

“…The mechanism of damage is believed to be related to the formation of radical species in the solvent by high-energy particles [29]. While the final injectable formulation can be stabilized against autoradiolysis with addition of radical scavengers (e.g., ethanol) to preserve radiochemical purity [30], this is not generally possible at earlier stages during the radiosynthesis process.…”

Section: Reduced Radiolysismentioning

confidence: 99%

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Advantages of Radiochemistry in Microliter Volumes

Keng

Sergeev

Dam

2016

Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy

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Positron emission tomography (PET) provides quantitative 3D visualization of physiological parameters (e.g., metabolic rate, receptor density, gene expression, blood flow) in real time in the living body. By enabling measurement of differences in such characteristics between normal and diseased tissues, PET serves as vital tool for basic research as well as for clinical diagnosis and patient management. Prior to a PET scan, the patient is injected with a short-lived tracer labeled with a positron-emitting isotope. Safe preparation of the tracer is an expensive process, requiring specially trained personnel and high-cost equipment operated within hot cells. The current centralized manufacturing strategy, in which large batches are prepared and divided among many patients, enables the most commonly used tracer (i.e., [ 18 F]FDG) to be obtained at an affordable price. However, as the diversity of tracers increases, other strategies for cost reduction will become necessary. This challenge is being addressed by the development of miniaturized radiochemistry instrumentation based on microfluidics. These compact systems have the potential to significantly reduce equipment cost and shielding while increasing diversity of tracers produced in a given facility. The most common approach uses "flow-through" microreactors, which leverage the ability to precisely control reaction conditions to improve synthesis times and yields. Several groups have also developed "batch" microreactors which offer significant additional advantages such as reduced reagent consumption, simpler purifications, and exceptionally high specific activity, by reducing operating volumes by orders of magnitude. In this chapter, we review these "batch" approaches and the advantages of using small volumes, with special emphasis on digital microfluidics, in which reactions have been performed with volumes as low as~1 μL.

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Section: Reduced Radiolysismentioning

confidence: 99%

Section: Reduced Radiolysismentioning

confidence: 99%

Advantages of Radiochemistry in Microliter Volumes

Keng

Sergeev

Dam

2016

Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy

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“…Buriova et al [70], combining mass spectrometry and radiometric detection, were able to evaluate the decomposition products of [ 18 F]FDG. Table 5.25 shows the decomposition products found in a 5.5 × 10 −5 M solution of [ 18 F]FDG, 30 hours after completion of the synthesis.…”

Section: Radiolysis Products Generated By Elevated Activity Of the Lamentioning

confidence: 99%

“…25 Content and Radiochemical Yields of the Products of Autoradiolysis of 5.5 × 10 −5 M [ 18 F]FDG Solution Calculated from Mass Spectrometric Signals Obtained 30Hours after the End of the Synthesis[70] …”

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confidence: 99%

Diagnostic Imaging Agents

Bohrer

2012

Sources of Contamination in Medicinal Products and Medical Devices

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“…It found that phosphate buffered reagent kits formed precipitation due to aluminium phosphate and thus did not recommend the use of phosphate buffered reagent kits even though another study found them to give the same radiochemical yield (Huang et al 2016 ; Long et al 2013 ). The main stability issue is radiation-related radiolysis of the active substance and solvents (Jószai et al 2019 ; Buriova et al 2005 ). These stability issues highlight the importance of this study.…”

Section: Introductionmentioning

confidence: 99%

Stability evaluation of [18F]FDG: literature study, stability studies from two different PET centres and future recommendations

Holler¹,

Renmælmo

Fjellaksel

2022

EJNMMI radiopharm. chem.

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Background The need for a stability evaluation of [18F]FDG is evident. The main purpose of this study was to make recommendations for determining the shelf life based on the available stability literature and our own two-centre stability studies. Results We performed a non-systematic literature study to find the most relevant stability data for [18F]FDG. The amount of radioactivity, radio-stabilizers, choice of synthesis, dilution, pH, temperature, storage and the choice of stability tests and acceptance criteria were the most important factors to evaluate for the implementation of good manufacturing practice. Moreover, we discuss some limitations of the study, especially the choice of synthesis, photostability, the environment, temperature and storage. Based on these data, we designed our own two-centre stability studies. All the defined acceptance criteria were met. Conclusions We have made recommendations for future stability evaluations based on our findings. The most important findings were that the amount of the radio-stabilizer ethanol should be > 0.1 % ethanol for activities up to 4 GBq/mL and > 0.2 % ethanol for activities up to 22.7 GBq/mL to keep [18F]FDG stable.

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Autoradiolysis of the 2-deoxy-2-[18F]fluoro-D-glucose radiopharmaceutical

Cited by 14 publications

References 0 publications

Advantages of Radiochemistry in Microliter Volumes

Advantages of Radiochemistry in Microliter Volumes

Diagnostic Imaging Agents

Stability evaluation of [18F]FDG: literature study, stability studies from two different PET centres and future recommendations

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