Autoradiographische Untersuchungen zur Verteilung von Mescalin und dessen Einfluß auf die zentrale Erregung bei Mäusen

Abstract

A utoradiographic Studies on the Distribution o/Mescaline and its Influence on the Central Excitation o/Mice Summary.After the injection of radioactive mescaline into mice the distribution of radioactivity was studied in different organs with biochemical and autoradiographic techniques. The half-life time of mescaline in the brain of mice was found to be about 55 rain. One hour after injection, the highest level of radioactivity was found in the soma rich areas of the cortex and of the brainstem. At this time the choroid plexus contained the highest amount of radioactivity within the brain. Six hours after the mescaline injection the radioactive material was concentrated more in the hippocampus compared with other areas of grey matter, whereas the plexus was nearly free of radioactivity. Motility increased parallel with the enrichment of the radioactivity in the cornu ammonis. Within the retina the layers with myelinated fibers were more radioactive than those containing the perikarya. A marked storage of radioactive material in the perikarya of the spinal ganglia was also observed. In the bone-marrow and in other reticulo-endothelial structures a high concentration of radioactivity was also found. In the liver the radioactivity was accumulated in the bile ducts and around the central veins. These autoradiograms were similar to the pictures which are obtained from Kupffer's cells by injection of Chinese ink. The adrenal medulla and the isles of Langerhans in the pancreas were also marked selectively.