Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse

Angevine, Jay B.; Sidman, Richard L.

doi:10.1038/192766b0

Cited by 1,414 publications

(752 citation statements)

References 3 publications

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“…No attempt was made to analyze the distributions according to control heterozygous (rllf) cortical layers (II-VI), and instead a radial division of the cortex into equalsized bins allowed direct spatial comparisons between homozygous reeler (rllrl) and control heterozygous (Al+) cortices. In accordance with the known wild-type deep-superficial neurogenic gradient (Angevine and Sidman, 1961;Smart and Smart, 1982;van der Kooy and Fishell, 1987;Miller and Nowakowski, 1988), Ell-labeled neurons in the control heterozygous (rl/+) cortices were located entirely within bins 5-10, with more than 40% in bin 10 alone. Heterozygous control (AS) E12-and E13-labeled neurons were also present primarily in deep bins, with E13-labeled neurons the most superficially represented population within the deep bins.…”

Section: Resultsmentioning

confidence: 67%

The mouse mutation reeler causes increased adhesion within a subpopulation of early postmitotic cortical neurons

et al. 1995

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Early postmitotic cortical neurons are mostly corticofugal projection neurons that take up positions in deep cortical laminae. Later postmitotic neurons are preferentially localized to superficial cortical laminae. In reeler mutant mice it appears that cortical laminar positions with respect to birthdate are reversed (Caviness, 1982). In a reanalysis of reeler lamination we found that early postmitotic cortical neurons labeled by embryonic day (E) 11–13 injections of a birthdate marker, or by early postnatal day (PND) 2 retrograde labeling through their output projections, appear to take up positions both in the superficial and deep cortex. Neurons born on E11 and E12 are more likely to be situated superficially in the reeler cortex and neurons born on E13 are more likely to be situated in the deep reeler cortex. Many corticofugal projection neurons in the deep (but not superficial) reeler cortex either die or retract their axons before PND 21. We hypothesize that the earliest postmitotic (E11-E12) of the early postmitotic reeler cortical neurons are overly adhesive and act as a barrier to later postmitotic migrating neurons. In vitro cortical aggregation cultures confirmed that early postmitotic (E12) reeler neurons are more adhesive than early postmitotic (E12) wild-type neurons or late postmitotic (E16) reeler or wild-type cortical neurons. We suggest that the moderate wild-type preferential adhesion of early postmitotic cortical neurons to each other helps deep and superficially fated lineages to form cortical laminae.

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Section: Resultsmentioning

confidence: 67%

The mouse mutation reeler causes increased adhesion within a subpopulation of early postmitotic cortical neurons

et al. 1995

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“…As new cortical plate neurons arrive on the same glial fibers, they migrate past the older neurons in the subplate and cortical plate before inserting directly beneath the Reln-rich marginal zone. The systematic migration of younger neurons past those generated at earlier times results in the classic inside-out pattern of development in the mammalian neocortex, in which the cortical plate (future layers II-VI) develops between the marginal zone (future layer I) and the subplate (Angevine and Sidman 1961;Rakic 1988).…”

Section: Reln and Cortical Developmentmentioning

confidence: 99%

Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS

Rice¹,

Curran²

1999

Genes & Development

141

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“…These layer-specific neuronal phenotypes are sequentially generated in the ventricular zone (VZ) of the dorsal telencephalon, and postmitotic neurons migrate to their destinations within the cortical plate (CP), in which later-born neurons migrate over earlier-born deeper-layer neurons and occupy more superficial layers (Angenvine and Sidman, 1961;Rakic, 1974). Recent genetic studies have identified various molecules involved in these processes (Rice and Curran, 1999;Soriano and del Rio, 2005).…”

Section: Introductionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Participates in Determination of Neuronal Laminar Fate in the Developing Mouse Cerebral Cortex

Fukumitsu¹,

Ohtsuka²,

Murai³

et al. 2006

J. Neurosci.

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Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse

Cited by 1,414 publications

References 3 publications

The mouse mutation reeler causes increased adhesion within a subpopulation of early postmitotic cortical neurons

The mouse mutation reeler causes increased adhesion within a subpopulation of early postmitotic cortical neurons

Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS

Brain-Derived Neurotrophic Factor Participates in Determination of Neuronal Laminar Fate in the Developing Mouse Cerebral Cortex

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