Autoradiographic studies with 3H 1,25 dihydroxyvitamin D3 in thyroid and associated tissues of the neck region

Stumpf, Walter E.; O'Brien, L. P.

doi:10.1007/bf00518724

Cited by 28 publications

(5 citation statements)

References 18 publications

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“…25OHD and 1,25(OH) 2 D can both cross the blood brain barrier [6,7]. Early immunohistochemistry studies first demonstrated the cellular and subcellular localization of the vitamin D receptor (VDR) and vitamin D metabolizing enzymes in human [8,9] and rodent brain [8,[10][11][12][13][14][15][16][17][18][19]].…”

Section: The Vitamin D Receptor and Vitamin D Metabolic Enzymes Are P...mentioning

confidence: 99%

Vitamin D and schizophrenia: 20 years on

et al. 2021

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Many epidemiological studies have highlighted the link between vitamin D deficiency and schizophrenia. In particular, two prominent studies report an association between neonatal vitamin D deficiency and an increased risk of schizophrenia. In parallel, much has been learnt about the role of vitamin D in the developing central nervous system over the last two decades. Studies in rodent models of developmental vitamin D (DVD)-deficiency describe how brain development is altered leading to a range of neurobiological and behavioral phenotypes of interest to schizophrenia. While glutamate and gamma aminobutyric acid (GABA) systems have been little investigated in these models, alterations in developing dopamine systems are frequently reported. There have been far more studies reporting patients with schizophrenia have an increased risk of vitamin D deficiency compared to well controls. Here we have conducted a systematic review and meta-analysis that basically confirms this association and extends this to first-episode psychosis. However, patients with schizophrenia also have poorer general health, poorer diets, are frequently less active and also have an increased risk of other medical conditions, all factors which reduce circulating vitamin D levels. Therefore, we would urge caution in any causal interpretation of this association. We also summarize the inconsistent results from existing vitamin D supplementation trials in patients with schizophrenia. In respect to animal models of adult vitamin D deficiency, such exposures produce subtle neurochemical alterations and effects on cognition but do not appear to produce behavioral phenotypes of relevance to schizophrenia. We conclude, the hypothesis that vitamin D deficiency during early life may increase the risk of schizophrenia remains plausible and warrants ongoing research.

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Section: The Vitamin D Receptor and Vitamin D Metabolic Enzymes Are P...mentioning

confidence: 99%

Vitamin D and schizophrenia: 20 years on

et al. 2021

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“…1982). Since then, other endocrine tissues have been discovered as targets for 1,25 D 3 , such as, adrenal medullary cells (Clark et al 1986), Sertoli cells in the testis (Stumpf et al 1987b), and thyroid follicle epithelial cells (Stumpf and O'Brien 1987), some of which may be under additional 1,25 D 3 -mediated neuro endocrine control.…”

Section: Introductionmentioning

confidence: 99%

1,25(OH)2 vitamin D3 sites of action in the brain

1987

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Summary. After injection of 3H 1,25 (OH}z vitamin D3 to adult rats and mice, under normal or vitamin D deficient diet, the hormone was found to be accumulated in nuclei of neurons in certain brain regions. Nuclear concentration was prevented or diminished, when excess unlabeled 1,25 (OHh vitamin D3 was injected before 3H 1,25 (OH)2 vitamin D 3 , while excess 25 (OH) vitamin D3 did not pre vent nuclear labeling.Highest nuclear concentration of 3H 1,25 (OHh vitamin D3 is observed in certain neurons in the nucleus interstitialis striae terminalis, involving its septo-preoptic pars dorsola teralis and its anterior hypothalamic-thalamic portion, and in the nucleus centralis of the amygdala, all constituting a system of target neurons linked by a component of the stria terminalis. Nuclear concentration of 3H 1,25 (OHh vitamin D3 is also found in neurons in the periventricular nucleus of the preoptic-hypothalamic region, including its extensions, the parvocellular paraventricular and arcuate nucleus, in the ventromedial nucleus, supramammillary nu cleus, reticular nucleus of the thalamus, ventral hippocam pus, caudate nucleus, pallium, in the midbrain-pontine cen tral gray, dorsal raphe nucleus, parabrachial nuclei, cranial motor nuclei, substantia gelatinosa of the sensory nucleus of the trigeminus, Golgi type II cells of the cerebellum, and others.The extensive distribution of target neurons suggests that 1,25 (OH)2 vitamin D3 regulates the production of sev eral aminergic and peptidergic messengers, and influences the activity of certain endocrine-autonomic, sensory and motor systems.

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“…The presence of receptors for 1,25-D3 in more than 90% of the nuclei of skeletal muscle cells in A. carolinensis is entirely different from the situation described in juvenile and adult rodents (Stumpf & O'Brien, 1987b;Stumpf, 1988) in which no receptors were found. However, nuclear labelling of striated muscles has been reported in chickens (Boland et al, 1985), zebra finches, yellow-bellied turtles, four anuran species, and teleost fish (Bidmon & Stumpf, unpublished).…”

Section: Discussionmentioning

confidence: 67%

“…However, in the sclera, which contains a single layer of chondrocytes, the variations in labelling intensity could be not related to an}, observable state of differentiation. The presence of receptor sites for 1,25-D3 in chondrocytes of A. carolinensis indicates that the steroid hormone is involved in the growth and differentiation of endoskeletal components of cartilage and bone similar to the condition reported for avian and mammalian species (Narbaitz et al, 1981;Marx et al, 1983;Stumpf & O'Brien, 1987b).…”

Section: Discussionmentioning

confidence: 75%

1,25-Dihydroxyvitamin D3 binding sites in the eye and associated tissues of the green lizard Anolis carolinensis

Bidmon¹,

Stumpf²

1995

Histochem J

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Receptor autoradiography was used for the demonstration of specific binding of the tritiated steroid hormone 1,25-dihydroxyvitamin D3 in the eyes and associated tissues of Anolis carolinensis. A 100-fold excess of non-labelled 1,25-dihydroxyvitamin D3 abolished specific nuclear binding of tracer. Nuclear [3H]-1,25-dihydroxyvitamin D3 binding was present in all animals in the retina stratum ganglionare and stratum nuclear externum as well as in the cornea; however, binding was absent in the optic nerve, except in cells of the surrounding arachnoidea. Additional cranial tissues such as chondrocytes in the sclera, parasphenoid, skeletal muscle cells, and epithelial cells of the lacrimal and Harderian glands exhibited nuclear labelling. The results suggest that 1,25-dihydroxyvitamin D3 has genomic regulatory actions that involve cell proliferation, differentiation, and functions of certain cells of the eye and associated cranial tissues. The presence of vitamin D receptors in tissues of the eye and skeletal muscle in the reptile is in part different from that observed in mammals. In general, receptors for vitamin D and related target tissues appear to be even more extensive in lizards than has been observed in rodents, which may reflect a more extensive dependency of these tissues on solar environment and active seasonal and circadian regulation.

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Autoradiographic studies with 3H 1,25 dihydroxyvitamin D3 in thyroid and associated tissues of the neck region

Cited by 28 publications

References 18 publications

Vitamin D and schizophrenia: 20 years on

Vitamin D and schizophrenia: 20 years on

1,25(OH)2 vitamin D3 sites of action in the brain

1,25-Dihydroxyvitamin D3 binding sites in the eye and associated tissues of the green lizard Anolis carolinensis

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