Autoradiographic Studies on Distribution of Radiocobalt Chloride in Pregnant Mice

Flodh, H

doi:10.3109/02841866809133185

Cited by 19 publications

(13 citation statements)

References 14 publications

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“…Hollins and McCullough [16] reported that at 10 72 h post intraperitoneal administration of radiolabelled cobalt chloride, the liver, skeleton and muscle contained 20 25% of total body activity with 7 8% accumulating in the kidney. [17] While it was not possible to determine the distribution pattern of cobalt in the current study, based on the large volume of distribution (Vd ss : 0.93 L/kg), cobalt also appears to be widely distributed in horses. In mice, cobalt disappearance from blood was nearly complete 24 h after injection of cobalt chloride.…”

Section: Discussionmentioning

confidence: 77%

Pharmacokinetics and selected pharmacodynamics of cobalt following a single intravenous administration to horses

Knych

Arthur

Mitchell

et al. 2014

Drug Testing and Analysis

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Cobalt has been used by human athletes due to its purported performance-enhancing effects. It has been suggested that cobalt administration results in enhanced erythropoiesis, secondary to increased circulating erythropoietin (EPO) concentrations leading to improvements in athletic performance. Anecdotal reports of illicit administration of cobalt to horses for its suspected performance enhancing effects have led us to investigate the pharmacokinetics and pharmacodynamic effects of this compound when administered in horses, so as to better regulate its use. In the current study, 18 horses were administered a single intravenous dose of cobalt chloride or cobalt gluconate and serum and urine samples collected for up to 10 days post administration. Cobalt concentrations were measured using inductively coupled plasma mass spectrometry (ICP-MS) and pharmacokinetic parameters determined. Additional blood samples were collected for measurement of equine EPO concentrations as well as to assess any effects on red blood cell parameters. Horses were observed for adverse effects and heart rate monitored for the first 4 h post administration. Cobalt was characterized by a large volume of distribution (0.939 L/kg) and a prolonged gamma half-life (156.4 h). Cobalt serum concentrations were still above baseline values at 10 days post administration. A single administration of cobalt had no effect on EPO concentrations, red blood cell parameters or heart rate in any of the horses studied and no adverse effects were noted. Based on the prolonged gamma half-life and prolonged residence time, regulators should be able to detect administration of a single dose of cobalt to horses.

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Section: Discussionmentioning

confidence: 77%

Pharmacokinetics and selected pharmacodynamics of cobalt following a single intravenous administration to horses

Knych

Arthur

Mitchell

et al. 2014

Drug Testing and Analysis

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show abstract

“…One of the earliest reported examples of tumour imaging with vitamin B 12 was that of Flodh and coworkers [24][25][26]. These workers used 58 Co-VB 12 and 60 Co-VB 12 in autoradiographic studies of fibroblastic osteosarcomas, spontaneous mammary carcinomas, Ehlich ascities and Moloney virus-induced tumours in mice.…”

Section: Imaging Using Vitamin B 12 Derivativesmentioning

confidence: 97%

Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumours

Russell‐Jones¹,

McTavish²,

McEwan³

et al. 2004

Journal of Inorganic Biochemistry

347

281

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“…Moreover, the patomechanism of the above developmental effects, seems to be different, for cadmium is known not to be transferred across the placenta (Goyer, 1991), whereas nickel and cobalt have been reported to cross this barrier and enter the fetus. (Sunderman et al, 1978;Flodh, 1968). Therefore the aim of the present study was to assess direct effects of these three toxic metals before placentation, i.e., during postblastocyst development in mice.…”

Section: Introductionmentioning

confidence: 99%

In VitroComparative Effect of Cd2+, Ni2+, and Co2+on Mouse Postblastocyst Development

Paksy

Forgács

Gáti

1999

Environmental Research

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Autoradiographic Studies on Distribution of Radiocobalt Chloride in Pregnant Mice

Cited by 19 publications

References 14 publications

Pharmacokinetics and selected pharmacodynamics of cobalt following a single intravenous administration to horses

Pharmacokinetics and selected pharmacodynamics of cobalt following a single intravenous administration to horses

Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumours

In VitroComparative Effect of Cd2+, Ni2+, and Co2+on Mouse Postblastocyst Development

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