Autoradiographic Studies of the Action of Leucogenenol on Leukocytes in the Bone Marrow, Spleen, and Peripheral Blood of the Rat

Rice, F. A. H.; Connolly, Jennifer M.; Aziz, Khalid; McCurdy, J. D.

doi:10.1093/infdis/123.2.117

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1972

1985

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Cited by 8 publications

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“…In tissue cultures of lymphoblastoid cells the preparation causes a marked change in the RQ as well as the rate of replication of the cells [14], increases the incorporation of DNA in the primitive proliferat ing pool of cells [15] and stimulates the rate of formation of lymphocytes from a precursor [16]. By degradation studies [17] leucogenenol was be lieved to be 2-(l, 2-dihydroxy-3-methyl-5-oxocyclohexyl)-3,11-dihydroxyll-(hydroxymethyl)-9-methyl-l-oxa-5-azaspiro (5,5) undeca-2,4-diene-7-one.…”

Section: Introductionmentioning

confidence: 99%

Effect of Leucogenenol on Human Peripheral Lymphocyte Cultures

Fumarola¹,

Marcuccio²,

Rinaldis³

1972

Pharmacology

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A purified preparation of leucogenenol in concentration of 1 µg/ml induces blastoid transformation in lymphocyte cultures (peripheral human blood). The percentage of blasts obtained is of the same order as following phytohaemagglutinin stimulation (60 and 75%, respectively). The results are briefly discussed in relation to blastogenic activity of the substance, prepared from a surface culture of Penicillium gilmanii.

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