1975
DOI: 10.1038/258349a0
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Autoradiographic localisation of α-bungarotoxin-binding sites in the central nervous system

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Cited by 130 publications
(32 citation statements)
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“…The overall autoradiographic method (18) for localizing receptors involves labeling receptors in slide-mounted tissue sections (19)(20)(21) in vitro and subsequent apposition of nuclear emulsion dried on cover slips (22 Fig. 1), whereas other sections were kept in the rinsing buffer for 1, 2, 5, 10, or 20 min.…”
Section: Methodsmentioning
confidence: 99%
“…The overall autoradiographic method (18) for localizing receptors involves labeling receptors in slide-mounted tissue sections (19)(20)(21) in vitro and subsequent apposition of nuclear emulsion dried on cover slips (22 Fig. 1), whereas other sections were kept in the rinsing buffer for 1, 2, 5, 10, or 20 min.…”
Section: Methodsmentioning
confidence: 99%
“…Additional support for its identity comes from the specific locations of the a-BTX-binding sites in this tissue (ref. 28; unpublished autoradiographic observations on the chick optic tectum). These sites are seen only in the zones known to contain nicotinic synapses.…”
Section: Affinity Labeling Of the A-btx-binding Components Frommentioning
confidence: 99%
“…The idea that certain neurotransmitter receptors are located predominantly at chemical synapses has been supported by acetylcholine (AcCh) sensitivity mapping of the skeletal muscle membrane (1) and parasympathetic neurons (2) and by electron microscopic identification of nicotinic AcCh receptor sites in the skeletal neuromuscular junction by a-bungarotoxin (aBT) binding (3)(4)(5). Radioactively labeled aBT has been used to detect nicotinic AcCh receptors in the central nervous system (6,7) and to determine their location by light microscopic autoradiography (8)(9)(10)(11)(12). However, there is no evidence, either from high resolution sensitivity mapping or from electron microscopy, for the precise location of the neurotransmitter receptors on neurons in any part of the central nervous system.…”
mentioning
confidence: 99%