Autoradiographic Localisation and Contractile Properties of Prostatic Endothelin Receptors in Patients with Bladder Outlet Obstruction

Mumtaz, Faiz; Dashwood, M; Thompson, CS; Khan, Masood; Naylor, A.M.; Mikhailidis, D.P.; Morgan, Robert J.

doi:10.1159/000052412

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…The magnitude of endothelin-1-induced contractions resembled that of noradrenaline-induced contractions, confirming that endothelin-1 may provide substantial components of human prostate smooth muscle tone. Endothelin-1-induced prostate contractions have previously been described human prostate tissues [30,[36][37][38][39][40][41][42][43]. However, comparisons of endothelin-1-induced contractions with a 1 -adrenergic contractions were rare, but reported consistently that both may be of similar magnitude [37,42].…”

Section: Discussionmentioning

confidence: 99%

Non‐Adrenergic, Tamsulosin‐Insensitive Smooth Muscle Contraction is Sufficient to Replace α₁‐Adrenergic Tension in the Human Prostate

et al. 2017

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Contractions following concomitant confrontation of human prostate tissue with noradrenaline and endothelin-1 are not additive. Endothelin-1 is sufficient to induce a smooth muscle tone resembling that of noradrenaline. This may replace lacking α -adrenergic tone under therapy with α -blockers, explaining the limited efficacy of α -blockers in LUTS treatment. Contractions by thromboxane and endothelin-1 may be additive, and may exceed α -adrenergic tone. Prostate 77:697-707, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Non‐Adrenergic, Tamsulosin‐Insensitive Smooth Muscle Contraction is Sufficient to Replace α₁‐Adrenergic Tension in the Human Prostate

et al. 2017

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“…Abnormalities of renal NO generation have been linked to pathogenesis of renal disease in diabetes [55,56]. Furthermore, Mumtaz et al [57] reported a progressive decline in NO production and, specifically, NO bioavailability in the kidney with advancing renal failure. Recently, Prabhakar et al [58] reported that total renal NO production, as reflected by urinary nitrite levels, was significantly decreased as a consequence of increased oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Renal oxidative stress and nitric oxide production in streptozotocin‐induced diabetic nephropathy in rats: the possible modulatory effects of garlic (Allium sativum L.)

Mariee

Abd‐Allah

El-Yamany

2009

Biotech and App Biochem

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The purpose of the present study was to investigate the effects of garlic (Allium sativum L.) on the diabetic nephropathy and oxidative stress induced by STZ (streptozotocin) in rats. Diabetes was induced in Male Sprague-Dawley rats by administering a single intraperitoneal injection of STZ (60 mg/kg of body weight). Administration of garlic, prepared as FGH (fresh garlic homogenate) significantly attenuated STZ-induced diabetic nephropathy as evaluated by assessment of serum glucose, insulin, total TAG (triacylglycerol), TC (total cholesterol) and Ccr (creatinine clearance) in control and STZ-induced diabetic rats. Urinary excretions of albumin and NAG (N-acetyl-beta-D-glucosaminidase) were also reduced following the treatment with FGH. In addition, significant inhibition of TBARSs (thiobarbituric acid-reacting substances) with a marked improvement of GSH content in the kidney homogenates was also observed. Moreover, renal tissue content and urinary excretion of nitrites were markedly decreased in this model, and virtually enhanced to the same levels as in the non-diabetic kidney following FGH supplementation. These data revealed that FGH has the ability to ameliorate STZ-induced diabetic nephropathy possibly through participation in the inhibition of oxidative damage to kidney and/or increased kidney nitric oxide bioavailability.

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“…104 ET receptors have been demonstrated and characterized in prostatic tissue by many investigators. [105][106][107][108][109][110][111][112][113][114] In patients with BPH, the density of these receptors was found to be increased. 107,108 Mumtaz et al 114 used high affinity ET A -and ET B -receptorspecific radioligands to determine the density and distribution of ET receptor subtypes in prostatic tissues obtained from patients with symptomatic BPH.…”

Section: Inhibitors/antagonists Of Endothelin Generation/receptorsmentioning

confidence: 99%

LUTS treatment: Future treatment options

2007

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Lower urinary tract symptoms (LUTS) are commonly divided into storage, voiding, and postmicturition symptoms, and may occur in both men and women. Male LUTS have historically been linked to benign prostatic hyperplasia (BPH), but are not necessarily prostate related. The focus of treatment for LUTS has thus shifted from the prostate to the bladder and other extraprostatic sites. LUTS include symptoms of the overactive bladder (OAB), which are often associated with detrusor overactivity. Treatment for LUTS suggestive of BPH has traditionally involved the use of alpha(1)-adrenoceptor (AR) antagonists; 5alpha-reductase inhibitors; and phytotherapy-however, several new therapeutic principles have shown promise. Selective beta(3)-adrenoceptor agonists and antimuscarinics are potentially useful agents for treating LUTS, particularly for storage symptoms secondary to outflow obstruction. Other agents of potential or actual importance are antagonists of P2X(3) receptors, botulinum toxin type A, endothelin (ET)-converting enzyme inhibitors, and drugs acting at vanilloid, angiotensin, and vitamin D(3) receptor sites. Drugs interfering with the nitric oxide/cGMP-cAMP pathway, Rho-kinase and COX inhibitors, as well as drugs targeting receptors and mechanisms within the CNS, are also of interest and deserving of further study for the treatment of LUTS.

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Autoradiographic Localisation and Contractile Properties of Prostatic Endothelin Receptors in Patients with Bladder Outlet Obstruction

Cited by 7 publications

References 22 publications

Non‐Adrenergic, Tamsulosin‐Insensitive Smooth Muscle Contraction is Sufficient to Replace α₁‐Adrenergic Tension in the Human Prostate

Non‐Adrenergic, Tamsulosin‐Insensitive Smooth Muscle Contraction is Sufficient to Replace α₁‐Adrenergic Tension in the Human Prostate

Renal oxidative stress and nitric oxide production in streptozotocin‐induced diabetic nephropathy in rats: the possible modulatory effects of garlic (Allium sativum L.)

LUTS treatment: Future treatment options

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Autoradiographic Localisation and Contractile Properties of Prostatic Endothelin Receptors in Patients with Bladder Outlet Obstruction

Cited by 7 publications

References 22 publications

Non‐Adrenergic, Tamsulosin‐Insensitive Smooth Muscle Contraction is Sufficient to Replace α1‐Adrenergic Tension in the Human Prostate

Non‐Adrenergic, Tamsulosin‐Insensitive Smooth Muscle Contraction is Sufficient to Replace α1‐Adrenergic Tension in the Human Prostate

Renal oxidative stress and nitric oxide production in streptozotocin‐induced diabetic nephropathy in rats: the possible modulatory effects of garlic (Allium sativum L.)

LUTS treatment: Future treatment options

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Non‐Adrenergic, Tamsulosin‐Insensitive Smooth Muscle Contraction is Sufficient to Replace α₁‐Adrenergic Tension in the Human Prostate

Non‐Adrenergic, Tamsulosin‐Insensitive Smooth Muscle Contraction is Sufficient to Replace α₁‐Adrenergic Tension in the Human Prostate