Autoradiographic characterization of the non‐N‐methyl‐D‐aspartate binding sites in human cerebellum using the antagonist [3H]6‐cyano‐7‐nitroquinoxaline‐2,3‐dione
Abstract:Using quantitative autoradiography, we have characterized the binding properties of the non-N-methyl-D-aspartate (NMDA) glutamate receptor antagonist [3H]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in adult human cerebellum. Saturation experiments revealed [3H]CNQX binding to a single class of sites with similar affinity in the molecular and granule cell layer (Kd = 89.0 +/- 6.4 and 83.3 +/- 9.9 nM, respectively). The maximum number of [3H]CNQX binding sites was much higher in the molecular compared to the gra… Show more
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