Autopsy findings in squamous-cell carcinoma of the esophagus

Anderson, Lynn L.; Lad, Thomas E.

doi:10.1002/1097-0142(19821015)50:8<1587::aid-cncr2820500820>3.0.co;2-s

Cited by 162 publications

(45 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They also analyzed macroscopic tumors unlike ours. Anderson and Lad (1982) described that the doubling time of squamous-cell carcinoma was calculated to be 48 to 70 days and it would take 4.5 years for few tumor cells to be a detectable one. The prognostic difference of subclinical tumors seems to become apparent not immediately but several years later.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of the Period between Surgery and Postoperative Irradiation in Esophageal Carcinoma.

Yamada

Takai

Nemoto

et al. 1994

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

One hundred and sixty-two esophageal carcinomas curatively resected and followed by postoperative irradiation were analyzed to investigate whether the delay of postoperative irradiation affected the patients' prognosis. The period of 40 or more days between surgery and postoperative irradiation caused significantly worse survival rates, and this fact was true even if the survival rates were corrected by the other significantly important prognostic factors : age and tumor staging. The incidence of infield recurrence and cancerous death were higher in the patients with the waiting period of 40 or more days. Significant repopulation of residual tumor cells in curatively resected esophageal carcinomas begins 40 days after surgery, therefore, postoperative irradiation should be started within 40 days after a radical resection. The difference of survival rates as related to the waiting period became clear after the follow-up of more than four years. The prognostic difference of subclinical tumors seems to be uncovered several years after treatment, esophageal carcinoma; surgery; postoperative irradiation; waiting period Postoperative irradiation for esophageal carcinoma has improved the prognosis (Kasai et al. 1978;Nishihira et al. 1984). In general, postoperative irradiation should be started as soon as possible after surgery, because a delay of the irradiation may result in regrowth of the residual tumor cells. However, in some patients the irradiation must be started far later after surgery for various reasons. Our data were analyzed to investigate whether the delay of postoperative irradiation actually causes worse prognosis of the patients. MATERIALS AND METHODSDuring the period from 1980 to 1989, 162 esophageal carcinomas were curatively resected and underwent more than 40 Gy of postoperative irradiation at the

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of the Period between Surgery and Postoperative Irradiation in Esophageal Carcinoma.

Yamada

Takai

Nemoto

et al. 1994

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…The influence of surgical selection is also illustrated by the high proportion of tumours within the lower third of the oesophagus. Post-mortem studies record squamous cell carcinoma as being most common in the middle third (Anderson & Lad, 1982) but the lower third tumours are more amenable to surgical treatment (Skinner, 1976) and have therefore been found to have a better prognosis (Miller, 1962). This trend was confirmed in this study with patients surviving longer who had tumours sited in the lower third versus upper and middle thirds.…”

Section: Discussionmentioning

confidence: 99%

Squamous carcinoma of the oesophagus: histological criteria and their prognostic significance

Edwards

Hillier²,

Lawson³

et al. 1989

Br J Cancer

View full text Add to dashboard Cite

Summary One hundred resected cases of squamous cell carcinomas of the oesophagus were reviewed and a series of histological criteria related to the survival time. Two histological features were important in the assessment of survival. Good prognostic factors were a marked lymphocytic response to the tumour and a lack of intravenous tumour infiltration. Presence of tumour in the middle third of the oesophagus, infiltration through the muscularis propria, severe tumour necrosis, glandular or small cell tumour differentiation, lymphatic invasion and lack of peritumoural fibrosis were all factors which tended to worsen prognosis. None of these factors reached statistical significance. The degree of squamous differentiation had no effect on survival.Oesophageal carcinoma is one of the most lethal cancers in terms of cure rates and survival. Obstructive symptoms present late, there is lack of surgical access to many of these tumours and a further adverse factor is the involvement of adjacent vital organs.Most histological studies in oesophageal carcinoma have been performed on autopsy cases (Mandard et al., 1981;Sons & Borchard, 1986

show abstract

“…10 Therefore, the diagnosis of renal metastases is very difficult, particularly in patients with esophageal cancer, and is often established accidentally on surveillance exams. Although previous study based on autopsy findings showed that 13% of esophageal cancer had metastatic lesions in the kidney, 11 such cases are rarely encountered in the clinical practice because they are asymptomatic. The present case in addition to the other 11 previously reported cases of esophageal cancer with renal metastasis and their treatment are briefly summarized in Table 1.…”

Section: Discussionmentioning

confidence: 95%

Esophageal Cancer with Solitary Renal Metastasis Treated with Multidisciplinary Therapy: A Case Report and Mini Review of the Literature

Nam

Jung

Park

et al. 2017

Korean J Helicobacter Up Gastrointest Res

View full text Add to dashboard Cite

Solitary renal metastasis of esophageal cancer is rarely encountered. Herein, we report the case of a 47-year-old man who developed a solitary renal metastasis after concurrent chemoradiotherapy followed by esophagectomy with esophagogastrostomy for esophageal squamous cell carcinoma, and treatment with nephrectomy and subsequent chemotherapy. Histopathological evaluation after operation revealed that the kidney mass was a metastatic lesion from esophageal cancer. He completed 15 cycles of palliative chemotherapy after nephrectomy and remained cancer-free for 36 months. Although lymph node metastasis occurred during regular follow-up, no evidence of lymph node metastasis was found on the imaging study after 9 cycles of chemotherapy with radiotherapy.

show abstract

Autopsy findings in squamous-cell carcinoma of the esophagus

Cited by 162 publications

References 8 publications

Prognostic Impact of the Period between Surgery and Postoperative Irradiation in Esophageal Carcinoma.

Prognostic Impact of the Period between Surgery and Postoperative Irradiation in Esophageal Carcinoma.

Squamous carcinoma of the oesophagus: histological criteria and their prognostic significance

Esophageal Cancer with Solitary Renal Metastasis Treated with Multidisciplinary Therapy: A Case Report and Mini Review of the Literature

Contact Info

Product

Resources

About