Autopsy findings in a case of acute paraquat poisoning with extensive cerebral purpura.

Mukada, Takeo; Sasano, Nobuaki; Satô, Kôzô

doi:10.1620/tjem.125.253

Cited by 11 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first report was by Grant et al, 2 who reported generalized edema, hemorrhages (both subependymal and subarachnoid), glial reactions (microglial activity and astrocytic response), and meningeal inflammation. These workers suggested that paraquat may damage the cerebral blood vessels because “the distribution of hemorrhages was unusual and resembled that seen in thiamine deficiency.” Other workers noted focal hemorrhages accompanied by a demyelinating process 20 …”

Section: Discussionmentioning

confidence: 94%

“…Other workers noted focal hemorrhages accompanied by a demyelinating process. 20 In addition to the pulmonary hemorrhagic effects described above, are the occurrence of intracranial hemorrhages described in cases of diquat exposure. Diquat poisoning has been extensively studied and has more often been associated with cerebral pathology than paraquat.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Histopathological Findings in a Fatal Case of Paraquat Poisoning

Moar

Hill

2021

Am J Forensic Med Pathol

View full text Add to dashboard Cite

Fatal paraquat ingestion presents many interesting pathological findings for the forensic pathologist. The majority of prior research regarding paraquat poisoning has focused on the lung and liver, this article is further directed to and presents some of the histopathological findings present in the brain. Typical macroscopic and histopathological findings of paraquat poisoning were identified in the liver and lungs. The brain was found to be edematous with widening of the centrum semiovale, whereas histologically, it was found that there was extravasation of erythrocytes into the surrounding Virchow-Robin spaces, a finding normally associated with blunt force head injury and, therefore, commonly interpreted by forensic pathologists as a cortical contusion hemorrhage.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Histopathological Findings in a Fatal Case of Paraquat Poisoning

Moar

Hill

2021

Am J Forensic Med Pathol

View full text Add to dashboard Cite

show abstract

“…Further, it was associated with focal hemorrhages of various stages accompanied by demyelinating processes of different extents. Globular and/or amorphous proteinaceous materials were also seen in the vascular lumina throughout the brain 15 .…”

Section: Introductionmentioning

confidence: 98%

“Paraquat Brain”: Have We Researched Enough?

KATTAMREDDY,

THATHAPUDİ,

GHOSH

et al. 2023

Eurasian Journal of Toxicology

View full text Add to dashboard Cite

This letter examines the potential relationship between the highly toxic herbicide paraquat (PQ) and Parkinson's disease (PD). Despite animal studies implicating PQ as a causative factor for PD, the evidence is insufficient due to limited human research on this topic. There is a pressing need for human autopsy-based studies in PQ poisoning fatalities to comprehend paraquat's neuropathology. Further studies are crucial to assess the morbidity in paraquat poisoning survivors, potentially shedding light on clinical links with PD. Although current research hasn't definitively established a causal connection, the absence of evidence shouldn't discourage ongoing investigation. The pursuit of understanding the PQ-PD connection necessitates unwavering commitment from the scientific community.

show abstract

An immunohistochemical study of the fibrosing process in paraquat lung injury

Manabe

Hayashi

1989

Vichows Archiv A Pathol Anat

View full text Add to dashboard Cite

Twenty-nine autopsy cases of paraquat-induced lung injury were studied by histological and immunohistochemical methods. Two stages of injury were identified. In the early stage, the alveolar epithelium degenerates but the epithelial basement membrane remains intact. In the late stage, the epithelial basement membrane is focally disrupted, the mesenchymal cells grow into the alveolar space, and intra-alveolar fibrosis appears. In spite of these pathological changes, the original framework of the alveolar wall is preserved in many areas. Intra-alveolar fibrosis may follow as a consequence of damage to the epithelium without severe damage to the underlying basement membrane, which occurs at the stage of organization. Morphological variants of intra-alveolar fibrosis seem to occur not only to the size of the defect of the basement membrane but also to the difference in the stages of evolution at the time the lesion is studied. The epithelium regenerates along the basement membrane in the early stage of re-epithelialization, but grows over the luminal aspect of intra-alveolar fibrous tissue which has been laid on the remaining basement membrane in the late stage. It is speculated that the regeneration of epithelial cells may develop without any association with the basement membrane when a fibrous tissue covers the original basement membrane.

show abstract

Autopsy findings in a case of acute paraquat poisoning with extensive cerebral purpura.

Cited by 11 publications

References 10 publications

Histopathological Findings in a Fatal Case of Paraquat Poisoning

Histopathological Findings in a Fatal Case of Paraquat Poisoning

“Paraquat Brain”: Have We Researched Enough?

An immunohistochemical study of the fibrosing process in paraquat lung injury

Contact Info

Product

Resources

About