Autopsy-determined causes of death in solid organ transplant recipients

Budiño, B Sanromán; Martul, Eduardo Vázquez; Díaz, Sonia Pértega; Barreiro, Álvaro; Rey, E Carro; Reboredo, Juan Mosquera

doi:10.1016/j.transproceed.2004.03.044

Cited by 36 publications

(21 citation statements)

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“…The causes of death were similar in the 2 groups and also were similar to those in other groups of OLT patients 34‐38. Infections were the leading cause of death for patients with sarcoidosis and for patients with PSC/PBC.…”

Section: Discussionsupporting

confidence: 76%

Outcomes of orthotopic liver transplantation for hepatic sarcoidosis: An analysis of the United Network for organ sharing/organ Procurement and Transplantation Network data files for a comparative study with cholestatic liver diseases

et al. 2011

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Hepatic sarcoidosis is a rare indication for liver transplantation. Using the United Network for Organ Sharing (UNOS)/Organ Procurement and Transplantation Network (OPTN) database, we evaluated patient and graft survival after orthotopic liver transplantation for sarcoidosis between October 1987 and December 2007. We assessed the potential prognostic value of multiple demographic and clinical variables, and we also compared these patients to a case-matched group of patients with primary sclerosing cholangitis (PSC) or primary biliary cirrhosis (PBC). The 1-and 5-year survival rates for the sarcoidosis group were 78% and 61%, respectively, and these rates were significantly worse than the rates for the PSC/PBC group (P ¼ 0.001). Disease recurrence in the liver is a rare cause of graft loss or patient death. Three deaths occurred in the sarcoidosis group because of recurrent hepatic sarcoidosis, and 1 death was a result of cardiac sarcoidosis. A univariate analysis identified an increasing donor risk index as a significant negative factor for outcomes for the sarcoidosis group [hazard ratio (HR) ¼ 2.06, confidence interval (CI) ¼ 1.04-4.06, P ¼ 0.037], but this finding was not found in a multivariate analysis, in which no independent predictors were found to have a significant impact. A case-matched univariate analysis demonstrated that sarcoidosis and morbid obesity were significant negative factors for outcomes, and in a multivariate analysis, sarcoidosis continued to predict worse outcomes (HR ¼ 2.39, CI ¼ 1.21-4.73, P ¼ 0.012). In conclusion, an analysis of the UNOS/OPTN database indicates that the patient and allograft survival rates for hepatic sarcoidosis are satisfactory, but they are worse in comparison with the rates for other cholestatic liver diseases.

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Section: Discussionsupporting

confidence: 76%

Outcomes of orthotopic liver transplantation for hepatic sarcoidosis: An analysis of the United Network for organ sharing/organ Procurement and Transplantation Network data files for a comparative study with cholestatic liver diseases

et al. 2011

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“…Infections are the leading cause of morbidity and mortality in solid organ transplantation (SOT), and bloodstream infections (BSIs), in particular, are associated with poor outcomes (1,2). Therefore, understanding the epidemiology of BSIs is imperative to develop strategies to reduce mortality.…”

mentioning

confidence: 99%

Epidemiology and risk factors for nosocomial bloodstream infections in solid organ transplants over a 10‐year period

Berenger

Doucette

Smith

2016

Transplant Infectious Dis

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“…Since its inception, survival after liver transplantation has significantly improved; the United Network for Organ Sharing reported an unadjusted 5‐year survival of 70.5% for deceased‐donor liver transplant recipients (LTRs) in the United States in 2007 . However, despite advances in surgical technique and immunosuppression, leading to improved survival, post‐transplant infection remains a major cause of morbidity and mortality in the liver transplant population . The incidence of colonization and infection with vancomycin‐resistant Enterococcus faecium (VRE) is particularly high in LTRs.…”

mentioning

confidence: 99%

A single‐center experience with infections due to daptomycin‐nonsusceptible Enterococcus faecium in liver transplant recipients

Lewis

Enfield

Cox

et al. 2016

Transplant Infectious Dis

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This study, the largest published series to our knowledge of DNSE infections in LTRs, demonstrates that these infections occur in patients with serious surgical complications and are associated with high morbidity and mortality. Established risk factors for VRE infection were common, as was DAP exposure. Although many risk factors for DNSE infection cannot be changed, this case series identifies several potentially modifiable variables. Further work is needed to identify interventions to decrease the risk of developing DNSE infections in this complex patient population.

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Autopsy-determined causes of death in solid organ transplant recipients

Cited by 36 publications

References 0 publications

Outcomes of orthotopic liver transplantation for hepatic sarcoidosis: An analysis of the United Network for organ sharing/organ Procurement and Transplantation Network data files for a comparative study with cholestatic liver diseases

Outcomes of orthotopic liver transplantation for hepatic sarcoidosis: An analysis of the United Network for organ sharing/organ Procurement and Transplantation Network data files for a comparative study with cholestatic liver diseases

Epidemiology and risk factors for nosocomial bloodstream infections in solid organ transplants over a 10‐year period

A single‐center experience with infections due to daptomycin‐nonsusceptible Enterococcus faecium in liver transplant recipients

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