Summary:The recent decline in autopsy rates has many causes and has been the subject of vigorous debate amongst clinicians, pathologists, and investigators. For cardiologists, the lack of direct information on the vessel wall may impede the ability to develop and interpret new imaging methods and to understand the effects of the newest interventions.Key words: autopsy, pathology, vessel wall, imaging, interventions These days, autopsy rates nationally are at an all-time low, with less than 5% of people dying in hospital undergoing autopsies. 1 The arguments for and against performing more autopsies have been well rehearsed.Those in favor argue that many significant abnormalities are missed when autopsies are neglected. Shojania et al. estimate that major diagnoses are missed in 8.4% of individuals dying in U.S. hospitals, and nearly half of these patients might have survived to discharge had the misdiagnosis not occurred. 2 A second argument for more autopsies is that without pathologic calibration, significant uncertainty will attach to the diagnoses in the medical record, a disadvantage not only for conscientious clinicians but also for databases and clinical trials. The relatives of the deceased also miss out on the chance for complete disclosure when events surrounding the death are unclear.The opponents of performing more autopsies point to the widespread use of imaging methods that virtually reproduce the same findings, and busy pathologists point to a lack of payment for any autopsy service they render. In today's adversarial environment, clinicians also fear the risk of a malpractice suit if undiagnosed problems are uncovered. On this last point, a study from the University of Pittsburgh Medical Center found that only one malpractice claim arose from 176 autopsies, and in that particular case the intent to litigate preceded the patient's death. 3 Even so, it is easy to understand the hesitation on the part of the sometimes already put-upon physician.Whatever their view, neither side can justify inordinate delays in the reporting of autopsy findings. Often many months pass before the full report is available to the clinician and family. It is similarly disappointing that there has been a lack of progress in the techniques applied, with apparently little advance in necropsy investigative methods during the last 50 years, in spite of the revolution in molecular pathology surrounding us. Scandalous stories in the international press serve to remind us that proper consent procedures and respect for all parts of the deceased are mandatory. 4,5 Residents, medical students, and nurses need better education on the rationale for performing autopsies and on the appropriate consent process. 6 What we have had, instead, is a lot of finger-pointing. Clinicians are not alone in suggesting that today's pathologists prefer the more lucrative and less onerous diagnostic patient-care services; such a complaint has also been issued from within the pathologists' own ranks. 7 To be fair, it must be discouraging that physician...