Autophagy-related MicroRNAs in chronic lung diseases and lung cancer

Rezaei, Samaneh; Mahjoubin‐Tehran, Maryam; Aghaee‐Bakhtiari, Seyed Hamid; Jalili, Amin; Movahedpour, Ahmad; Khan, Haroon; Moghoofei, Mohsen; Shojaei, Zahra; Hamblin, Michael R.; Mirzaei, Hamed

doi:10.1016/j.critrevonc.2020.103063

Cited by 49 publications

(18 citation statements)

References 210 publications

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“…Autophagy is an evolutionarily conserved cellular catabolic process that has a critical role in maintaining cellular homeostasis through the lysosomal degradation of unnecessary or dysfunctional components during metabolic stress, pathogenic infection, radiation damage, and drug therapy 37 . Since it has been served in both pro-survival and pro-apoptotic mechanisms, the role of autophagy in cancer cell biology is complicated and evolves throughout tumorigenesis 28 , 30 , 38 , 39 . In this study, TMZ-resistant GBM cell lines showed enhanced autophagic processes, such as increased expression of the autophagy-related gene as well as acidic autolysosome formation after TMZ treatment.…”

Section: Discussionmentioning

confidence: 99%

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma

et al. 2020

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Temozolomide (TMZ) is widely used for treating glioblastoma multiforme (GBM), however, the treatment of such brain tumors remains a challenge due to the development of resistance. Increasing studies have found that TMZ treatment could induce autophagy that may link to therapeutic resistance in GBM, but, the precise mechanisms are not fully understood. Understanding the molecular mechanisms underlying the response of GBM to chemotherapy is paramount for developing improved cancer therapeutics. In this study, we demonstrated that the loss of DOC-2/DAB2 interacting protein (DAB2IP) is responsible for TMZ-resistance in GBM through ATG9B. DAB2IP sensitized GBM to TMZ and suppressed TMZ-induced autophagy by negatively regulating ATG9B expression. A higher level of ATG9B expression was associated with GBM compared to low-grade glioma. The knockdown of ATG9B expression in GBM cells suppressed TMZ-induced autophagy as well as TMZ-resistance. Furthermore, we showed that DAB2IP negatively regulated ATG9B expression by blocking the Wnt/β-catenin pathway. To enhance the benefit of TMZ and avoid therapeutic resistance, effective combination strategies were tested using a small molecule inhibitor blocking the Wnt/β-catenin pathway in addition to TMZ. The combination treatment synergistically enhanced the efficacy of TMZ in GBM cells. In conclusion, the present study identified the mechanisms of TMZ-resistance of GBM mediated by DAB2IP and ATG9B which provides insight into a potential strategy to overcome TMZ chemo-resistance.

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Section: Discussionmentioning

confidence: 99%

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma

et al. 2020

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“…Lung cancer is a leading cause of cancer death, and 85% of cases are non-small cell lung carcinomas (NSCLC) with an average 5-year survival of only 4% (134). SOX2 (sex determining region Y)-box 2 is a transcription factor that is essential for maintaining the pluripotency of undifferentiated embryonic stem cells and lung cancer stem cells (135).…”

Section: Salmonella Bacteria In Combination Therapiesmentioning

confidence: 99%

Use of Salmonella Bacteria in Cancer Therapy: Direct, Drug Delivery and Combination Approaches

et al. 2021

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Over the years, conventional cancer treatments, such as chemotherapy with only a limited specificity for tumors, have undergone significant improvement. Moreover, newer therapies such as immunotherapy have undergone a revolution to stimulate the innate as well as adaptive immune responses against the tumor. However, it has been found that tumors can be selectively colonized by certain bacteria, where they can proliferate, and exert direct oncolytic effects as well as stimulating the immune system. Bacterial-mediated cancer therapy (BMCT) is now one example of a hot topic in the antitumor field. Salmonella typhimurium is a Gram-negative species that generally causes self-limiting gastroenteritis in humans. This species has been designed and engineered in order to be used in cancer-targeted therapeutics. S. typhimurium can be used in combination with other treatments such as chemotherapy or radiotherapy for synergistic modification of the tumor microenvironment. Considerable benefits have been shown by using engineered attenuated strains for the diagnosis and treatment of tumors. Some of these treatment approaches have received FDA approval for early-phase clinical trials. This review summarizes the use of Salmonella bacteria for cancer therapy, which could pave the way towards routine clinical application. The benefits of this therapy include an automatic self-targeting ability, and the possibility of genetic manipulation to produce newly engineered attenuated strains. Nevertheless, Salmonella-mediated anticancer therapy has not yet been clinically established, and requires more research before its use in cancer treatment.

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“…Briefly, miRs belong to non-coding RNAs (ncRNAs) from the subcategory of regulatory RNAs [ 76 , 77 , 78 ]. Although miRs comprise a large section of genome and are not translated into proteins, they exert regulatory effects on important cellular events, such as proliferation, migration, and so on [ 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ]. In terms of regulation of the PTEN signaling pathway, miRs have demonstrated great potential.…”

Section: Pten and Gastric Cancermentioning

confidence: 99%

PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation

et al. 2020

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Cancer is one of the life-threatening disorders that, in spite of excellent advances in medicine and technology, there is no effective cure for. Surgery, chemotherapy, and radiotherapy are extensively applied in cancer therapy, but their efficacy in eradication of cancer cells, suppressing metastasis, and improving overall survival of patients is low. This is due to uncontrolled proliferation of cancer cells and their high migratory ability. Finding molecular pathways involved in malignant behavior of cancer cells can pave the road to effective cancer therapy. In the present review, we focus on phosphatase and tensin homolog (PTEN) signaling as a tumor-suppressor molecular pathway in gastric cancer (GC). PTEN inhibits the PI3K/Akt pathway from interfering with the migration and growth of GC cells. Its activation leads to better survival of patients with GC. Different upstream mediators of PTEN in GC have been identified that can regulate PTEN in suppressing growth and invasion of GC cells, such as microRNAs, long non-coding RNAs, and circular RNAs. It seems that antitumor agents enhance the expression of PTEN in overcoming GC. This review focuses on aforementioned topics to provide a new insight into involvement of PTEN and its downstream and upstream mediators in GC. This will direct further studies for evaluation of novel signaling networks and their targeting for suppressing GC progression.

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Autophagy-related MicroRNAs in chronic lung diseases and lung cancer

Cited by 49 publications

References 210 publications

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma

Use of Salmonella Bacteria in Cancer Therapy: Direct, Drug Delivery and Combination Approaches

PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation

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