Autophagy Regulates Ageing in<i>C. elegans</i>

Hars, Eszter S.; Qi, Haiyan; Ryazanov, Alexey G.; Jin, Shengkan; Cai, Li; Hu, Chengcheng; Liu, Leroy F.

doi:10.4161/auto.3636

Cited by 216 publications

(164 citation statements)

References 17 publications

Supporting

Mentioning

156

Contrasting

Unclassified

Order By: Relevance

“…RNAi-mediated knockdown of the autophagy regulator bec-1 shortens the lifespan of long-lived daf-2 mutant animals (Kenyon, 2005;Melendez et al, 2003). Moreover, knockdown of the atg-7 and atg-12 C. elegans orthologues shortens the lifespan of both wild-type animals and daf-2 mutants (Hars et al, 2007). Consistent with these findings, loss-of-function mutations in bec-1, atg-18 and lgg-1 abrogate the long-lived phenotype of daf-2 mutants (Toth et al, 2008).…”

Section: Insulin/igf-1 Signallingmentioning

confidence: 99%

“…Normal dauer larvae are resistant to 1% SDS (Cassada and Russell, 1975). Reduced autophagy results in the formation of abnormal dauer larvae with altered morphology, which lack resistance to SDS and are not long-lived (Hars et al, 2007;Melendez et al, 2003). Knockdown of the autophagy gene bec-1 shortens lifespan of both wild-type and daf-2 mutant worms.…”

Section: Autophagy and Dauer Formation In C Elegansmentioning

confidence: 99%

“…Accumulating findings indicate that clearing cellular damage by autophagy is a common denominator of different lifespan -influencing pathways in diverse organisms including yeast, worms, flies and mammals (Bjedov et al, 2010;Giannakou and Partridge, 2007;Hansen et al, 2008;Hars et al, 2007;Levine and Kroemer, 2008;Toth et al, 2008). Here, we review recent research developments that highlight the interaction of autophagy with several evolutionarily conserved mechanisms linked to longevity.…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Autophagy and ageing: Insights from invertebrate model organisms

Lionaki

Markaki

Tavernarakis

2013

Ageing Research Reviews

View full text Add to dashboard Cite

a b s t r a c tAgeing in diverse species ranging from yeast to humans is associated with the gradual, lifelong accumulation of molecular and cellular damage. Autophagy, a conserved lysosomal, self-destructive process involved in protein and organelle degradation, plays an essential role in both cellular and whole-animal homeostasis. Accumulating evidence now indicates that autophagic degradation declines with age and this gradual reduction of autophagy might have a causative role in the functional deterioration of biological systems during ageing. Indeed, loss of autophagy gene function significantly influences longevity. Moreover, genetic or pharmacological manipulations that extend lifespan in model organisms often activate autophagy. Interestingly, conserved signalling pathways and environmental factors that regulate ageing, such as the insulin/IGF-1 signalling pathway and oxidative stress response pathways converge on autophagy. In this article, we survey recent findings in invertebrates that contribute to advance our understanding of the molecular links between autophagy and the regulation of ageing. In addition, we consider related mechanisms in other organisms and discuss their similarities and idiosyncratic features in a comparative manner.

show abstract

Section: Insulin/igf-1 Signallingmentioning

confidence: 99%

Section: Autophagy and Dauer Formation In C Elegansmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Autophagy and ageing: Insights from invertebrate model organisms

Lionaki

Markaki

Tavernarakis

2013

Ageing Research Reviews

View full text Add to dashboard Cite

show abstract

“…In C. elegans, impaired autophagy by knockdown (mutant) of worm bec-1, homologue of yeast VPS30/ mammalian beclin1 [75], as well as atg-7 and atg-12 [76], blocks lifespan extension by a daf-2 mutant. Similarly, lifespan extension via reduced TOR signalling (let-363 aka CeTOR RNAi) has been shown to depend on bec-1, and extension by dietary restriction (eat-2 mutants) has been shown to depend on both bec-1 and vps-34 [77].…”

Section: Introductionmentioning

confidence: 99%

TOR and ageing: a complex pathway for a complex process

McCormick

Tsai

Kennedy

2011

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

Studies in invertebrate model organisms have led to a wealth of knowledge concerning the ageing process. But which of these discoveries will apply to ageing in humans? Recently, an assessment of the degree of conservation of ageing pathways between two of the leading invertebrate model organisms, Saccharomyces cerevisiae and Caenorhabditis elegans, was completed. The results (i) quantitatively indicated that pathways were conserved between evolutionarily disparate invertebrate species and (ii) emphasized the importance of the TOR kinase pathway in ageing. With recent findings that deletion of the mTOR substrate S6K1 or exposure of mice to the mTOR inhibitor rapamycin result in lifespan extension, mTOR signalling has become a major focus of ageing research. Here, we address downstream targets of mTOR signalling and their possible links to ageing. We also briefly cover other ageing genes identified by comparing worms and yeast, addressing the likelihood that their mammalian counterparts will affect longevity.

show abstract

“…Morck and Pilon (2007) demonstrated increased autophagic action as well as smaller cell size in feeding-defective mutants. Hars et al (2007) followed up on studies where RNAi-mediated knock-down of bec-1, a key gene in autophagy, shortened the long life of daf-2 mutants. Here they knocked down two other autophagy genes, atg-7 and atg-12 and showed that RNAi shortened the lifespan of both wild type and daf-2, although not very much.…”

Section: Autophagymentioning

confidence: 99%

Caenorhabditis elegans 2007: The premier model for the study of aging

Johnson

2007

Experimental Gerontology

View full text Add to dashboard Cite

This is the 25 th anniversary of the discovery of extended longevity mutants in Caenorhabditis elegans. About one hundred papers describing results from studies on C. elegans in aging research appeared this year. Many themes were pursued including dietary restriction, daf-9 action, the role of proteolysis and autophagy, and the continued search for more Age mutants. I use the word "modulate" not "regulate" so as to be consistent with the evolutionary theory of aging, which is also consistent with the empirical findings of all extended-longevity (Age) mutants. These Age mutants universally result from deficits in known physiologic systems, rather than in some process designed to kill the animal in old age. KeywordsGenetics of aging; Aging models; Inflammation; Immune Response; Dietary Restriction; Protein Synthesis; Drugs; Longevity Mutants This year marks the 25 th anniversary of the use of extended longevity mutants of Caenorhabditis elegans to identify processes involved in aging of this species (Johnson and Wood, 1982). About one hundred papers appeared this year, far more than we can review in detail here. Many themes were pursued and will be highlighted below. These include dietary restriction, daf-9 action, the role of proteolysis and autophagy, and the continued search for more Age mutants. Note that I use the word "modulate" not "regulate" so as to be consistent with the evolutionary theory of aging and the empirical findings of many extended-longevity mutants, which show that these mutants all result from deficits in known physiologic systems, rather than in some process designed to kill the animal in old age.

show abstract

Autophagy Regulates Ageing inC. elegans

Abstract: Previously published online as an Autophagy E-Publication: http://www.landesbioscience.com/journals/autophagy/abstract.php?id=3636 KEy woRdSageing, autophagy, lifespan, atg-7, atg-12, bec-1, daf-2 ACKnowLEdGEmEntS

Cited by 216 publications

References 17 publications

Autophagy and ageing: Insights from invertebrate model organisms

Autophagy and ageing: Insights from invertebrate model organisms

TOR and ageing: a complex pathway for a complex process

Caenorhabditis elegans 2007: The premier model for the study of aging

Contact Info

Product

Resources

About