Autophagy-preferential degradation of<i>MIR224</i>participates in hepatocellular carcinoma tumorigenesis

Lan, Sheng Hui; Wu, Sihan; Zuchini, Roberto; Lin, Xi Zhang; Su, Ih Jen; Tsai, Ting Fen; Lin, Yen Ju; Wu, Chih Chiang; Liu, Hsiao Sheng

doi:10.4161/auto.29959

Cited by 44 publications

(29 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autophagy promotes degradation of cellular microRNA-224, whose overexpression is associated with hepatocellular carcinoma. (Lan et al, 2014a) Autophagy specifically has been shown to suppress HBV-associated tumor formation by degrading microRNA-224. (Lan et al, 2014b)…”

Section: Autophagic Membranes In Classical Viral Envelope Formationmentioning

confidence: 99%

Viruses and the autophagy pathway

2015

View full text Add to dashboard Cite

Studies of the cellular autophagy pathway have exploded over the past twenty years. Now appreciated as a constitutive degradative mechanism that promotes cellular homeostasis, autophagy is also required for a variety of developmental processes, cellular stress responses, and immune pathways. Autophagy certainly acts as both an anti-viral and pro-viral pathway, and the roles of autophagy depend on the virus, the cell type, and the cellular environment. The goal of this review is to summarize, in brief, what we know so far about the relationship between autophagy and viruses, particularly for those who are not familiar with the field. With a massive amount of relevant published data, it is simply not possible to be comprehensive, or to provide a complete “parade of viruses”, and apologies are offered to researchers whose work is not described herein. Rather, this review is organized around general themes regarding the relationship between autophagy and animal viruses.

show abstract

Section: Autophagic Membranes In Classical Viral Envelope Formationmentioning

confidence: 99%

Viruses and the autophagy pathway

2015

View full text Add to dashboard Cite

show abstract

“…Dysregulated miRNA expression is frequently involved in the development of many human tumor types. 6, 7 In addition, studies show involvement of miRNA in resistance of cancer cells to chemotherapeutic drugs. 8, 9, 10 Moreover, upregulation of miRNAs expression causes tamoxifen resistance in breast cancer cells, such as miR-221/222, 11 whereas miR-342 and miR-378a confer tamoxifen sensitivity by inhibiting their target genes.…”

mentioning

confidence: 99%

Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression

et al. 2016

View full text Add to dashboard Cite

Estrogen-dependent breast cancer is often treated with the aromatase inhibitors or estrogen receptor (ER) antagonists. Tamoxifen as a major ER antagonist is usually used to treat those patients with ERα-positive breast cancer. However, a majority of patients with ERα positive fail to respond to tamoxifen due to the presence of intrinsic or acquired resistance to the drug. Altered expression and functions of microRNAs (miRNAs) have been reportedly associated with tamoxifen resistance. In this study, we investigated the role of miR-27b-3p in resistance of breast cancer to tamoxifen. MiR-27b-3p levels were remarkably reduced in the tamoxifen-resistant breast cancer cells compared with their parental cells. In addition, miR-27b-3p was also significantly downregulated in breast tumor tissues relative to adjacent non-tumor tissues. Moreover, the expression levels of miR-27b-3p were lower in the breast cancer tissues from tamoxifen-resistant patients compared with that from untreated-tamoxifen patients. Notably, tamoxifen repressed miR-27b-3p expression, whereas estrogen induced miR-27b-3p expression in breast cancer cells. Besides, we provided experimental evidences that miR-27b-3p enhances the sensitivity of breast cancer cells to tamoxifen in vitro and in vivo models. More importantly, we validated that miR-27b-3p directly targeted and inhibited the expression of nuclear receptor subfamily 5 group A member 2 (NR5A2) and cAMP-response element binding protein 1 (CREB1) and therefore augmented tamoxifen-induced cytotoxicity in breast cancer. Lastly, miR-27b-3p levels were found to be significantly negatively correlated with both NR5A2 and CREB1 levels in breast cancer tissues. Our findings provided further evidence that miR-27b-3p might be considered as a novel and potential target for the diagnosis and treatment of tamoxifen-resistant breast cancer.

show abstract

“…As previously mentioned, linc-POU3F3 was an oncogene that silencing linc-POU3F3 inhibited proliferation and migration, induced apoptosis in CRC. SMAD4, which is involved in TGF-β-induced autophagy, showed an increase because of linc-POU3F3 knockdown [52, 53]. In addition, autophagy related protein, BECLIN1, ATG5, ATG7, and LC3 II, were continually accumulated by linc-POU3F3 knockdown due to interdicted autophagy in CRC [53].…”

Section: The Role Of Lncrnas In Crcmentioning

confidence: 99%

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

Sun¹,

Wang²,

Chen³

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Colorectal cancer (CRC) is one of the most common malignancies in the world. Easier recurrence and metastasis is the main cause of mortality in CRC patients, and the markers applied for diagnosis and treatment of CRC is still urgently needed to early diagnose and evaluate therapeutic effect. Long noncoding RNA (lncRNA) is a class of noncoding RNA that the length is more than 200 nucleotides. With the development of sequencing technique about transcriptome, increasing lncRNAs are focused on their function and mechanism related to the nosogenesis and pathology of CRC. Recent studies report that lncRNAs acted as crucial role in CRC and could be as biomarker for CRC diagnosis and treatment. In this review, we display the regulation of lncRNA by interacting with DNA, RNA and protein and highlight the double role of lncRNAs as oncogene or anti-tumor gene involved in Wnt signaling pathway, p53 signaling pathway or others to be an regulator in CRC development. Lastly, we discuss some new finding of lncRNAs, especially lncRNA in exosome, which could be as potential markers for diagnosis and treatment of CRC in future.

show abstract

Autophagy-preferential degradation ofMIR224participates in hepatocellular carcinoma tumorigenesis

Cited by 44 publications

References 0 publications

Viruses and the autophagy pathway

Viruses and the autophagy pathway

Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

Contact Info

Product

Resources

About