Autophagy, Oxidative Stress and Cancer Development

Taucher, Elisabeth; Mykoliuk, Iurii; Fediuk, Melanie; Smolle‐Jüttner, Freyja‐Maria

doi:10.3390/cancers14071637

Cited by 28 publications

(18 citation statements)

References 179 publications

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“…therefore, autophagy discussed in this study refers specifically to macro-autophagy. Autophagy is involved in various physiological and pathological processes within an organism, including development, [75] tumor suppression, [76][77][78] antigen presentation, [79,80] cellular survival, [81] programmed cell death, [82,83] inflammatory balance, [84] and aging. [85,86] It primarily functions as a cellular protective mechanism that requires rigorous regulation.…”

Section: Mechanisms Underlying Autophagymentioning

confidence: 99%

Role of autophagy in skin photoaging: A narrative review

Zhong,

Deng,

Yang

et al. 2024

Medicine

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As the largest organ of the human body, the skin serves as the primary barrier against external damage. The continuous increase in human activities and environmental pollution has resulted in the ongoing depletion of the ozone layer. Excessive exposure to ultraviolet (UV) radiation enhances the impact of external factors on the skin, leading to photoaging. Photoaging causes physical and psychological damage to the human body. The prevention and management of photoaging have attracted increased attention in recent years. Despite significant progress in understanding and mitigating UV-induced photoaging, the precise mechanisms through which autophagy contributes to the prevention of photoaging remain unclear. Given the important role of autophagy in repairing UV-induced DNA damage and scavenging oxidized lipids, autophagy is considered a novel strategy for preventing the occurrence of photoaging and other UV light-induced skin diseases. This review aims to elucidate the biochemical and clinical features of photoaging, the relationship of skin photoaging and chronological aging, the mechanisms underlying skin photoaging and autophagy, and the role of autophagy in skin photoaging.

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Section: Mechanisms Underlying Autophagymentioning

confidence: 99%

Role of autophagy in skin photoaging: A narrative review

Zhong,

Deng,

Yang

et al. 2024

Medicine

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“…4.1 Nutritional strategies: Fasting, phytochemicals, phytomelatonin, and fermented food 4.1.1 Fasting Fasting is an effective way to recover mitochondrial efficiency, and multiple human studies have shown its ability to restore metabolic pathways in people suffering from chronic pathologies. Fasting regimens are promising primary and secondary prevention strategies in patients suffering from metabolic and cardiovascular diseases (Oliveira et al, 2022;Papakonstantinou et al, 2022;Vasim et al, 2022;Zang et al, 2022), pain, inflammation and immune conditions (Feng et al, 2022;Fitzgerald et al, 2022;Parveen and Alhazmi, 2022), cancer (Lv et al, 2014;Marinac et al, 2016;Taucher et al, 2022;Tiwari et al, 2022), and neurological diseases characterized by altered mood, sleep, pain, and cognition (Phillips, 2019;Brocchi et al, 2022;Caron et al, 2022;Feng et al, 2022;Lobo et al, 2022;Xu et al, 2022).…”

Section: Figurementioning

confidence: 99%

Mitochondria: It is all about energy

et al. 2023

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Mitochondria play a key role in both health and disease. Their function is not limited to energy production but serves multiple mechanisms varying from iron and calcium homeostasis to the production of hormones and neurotransmitters, such as melatonin. They enable and influence communication at all physical levels through interaction with other organelles, the nucleus, and the outside environment. The literature suggests crosstalk mechanisms between mitochondria and circadian clocks, the gut microbiota, and the immune system. They might even be the hub supporting and integrating activity across all these domains. Hence, they might be the (missing) link in both health and disease. Mitochondrial dysfunction is related to metabolic syndrome, neuronal diseases, cancer, cardiovascular and infectious diseases, and inflammatory disorders. In this regard, diseases such as cancer, Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), chronic fatigue syndrome (CFS), and chronic pain are discussed. This review focuses on understanding the mitochondrial mechanisms of action that allow for the maintenance of mitochondrial health and the pathways toward dysregulated mechanisms. Although mitochondria have allowed us to adapt to changes over the course of evolution, in turn, evolution has shaped mitochondria. Each evolution-based intervention influences mitochondria in its own way. The use of physiological stress triggers tolerance to the stressor, achieving adaptability and resistance. This review describes strategies that could recover mitochondrial functioning in multiple diseases, providing a comprehensive, root-cause-focused, integrative approach to recovering health and treating people suffering from chronic diseases.

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“…There is a system that inhibited free radical reaction in the body, so that excessive free radicals in the body are scavenged [45]. However, if this reaction system is damaged, excessive free radicals will directly cause damage to human cells [46]. It could be seen that the generation of oxidative stress in organisms is caused by the increase in the number of free radicals or the decline in the antioxidant defense function [47].…”

Section: Ligand Fishing Assay For Selaginella Doederleinii Ethyl Acet...mentioning

confidence: 99%

Lactate Dehydrogenase-Inhibitors Isolated from Ethyl Acetate Extract of Selaginella doederleinii by Using a Rapid Screening Method with Enzyme-Immobilized Magnetic Nanoparticles

Zhang¹,

Li²,

Liu³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: Lactate dehydrogenase (LDH) is one of the important enzyme systems for glycolysis and gluconeogenesis. It can catalyze the reduction and oxidation reaction between propionic acid and L-lactic acid, which is usually overexpressed in cancer cells. Therefore, inhibiting the activity of LDH is a promising way for the treatment of cancer. In this study, an effective method based on ligand fishing and ultra performance liquid chromatography-mass spectrum (UPLC-MS) was established to screen and identify active ingredients from Selaginella doederleinii with potential inhibitory activity for LDH. Methods: Firstly, LDH was immobilized on the magnetic nanoparticles (MNPs), three immobilization parameters including LDH concentration, immobilization time and pH were optimized by single factor and response surface methodology for maximum (max) immobilization yield. Then, a mixed model of galloflavin and chlorogenic acid (inhibitors and non-inhibitors of LDH) was used to verify the specificity of immobilized LDH ligand fishing, and the conditions of ligand fishing were further optimized. Finally, combined with UPLC-MS, immobilized LDH was used to simultaneously screen and identify potential LDH inhibitors from the ethyl acetate extract of Selaginella doederleinii. Results: The prepared fishing material was comprehensively characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD) and fourier transform infrared spectrometer (FT-IR). The optimal immobilization conditions were obtained as LDH concentration of 0.7 mg/mL, pH value of 4.5, and immobilization time of 3.5 h. Under these conditions, the max immobilization yield was (3.79 ± 0.08) × 10 3 U/g. The specificity analysis showed that immobilized LDH could recognize and capture ligands, and the optimal ligand fishing conditions included that the incubation time was 30 min, the elution time was 20 min, and the concentration of methanol as eluent was 80%. Finally, two LDH inhibitors, amentoflavone and robustaflavone, were screened by immobilized LDH from the ethyl acetate extract of Selaginella doederleinii. Conclusions: The study provided a meaningful evidence for discovering the bioactive constituents in ethyl acetate extract of Selaginella doederleinii related to cancer treatment, and this ligand fishing method was feasible for screening enzyme inhibitors from similar complex mixtures.

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Autophagy, Oxidative Stress and Cancer Development

Cited by 28 publications

References 179 publications

Role of autophagy in skin photoaging: A narrative review

Role of autophagy in skin photoaging: A narrative review

Mitochondria: It is all about energy

Lactate Dehydrogenase-Inhibitors Isolated from Ethyl Acetate Extract of Selaginella doederleinii by Using a Rapid Screening Method with Enzyme-Immobilized Magnetic Nanoparticles

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