2018
DOI: 10.1016/j.neulet.2018.06.052
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Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging

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Cited by 20 publications
(13 citation statements)
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“…Previous research showed that PD is linked with the accumulation of intracellular inclusions known as Lewy bodies under stressful conditions and lessened UPS activity [ 59 ] and autophagy function [ 60 ]. Thus, augmenting the UPS or autophagy with the resultant degradation of misfolded and aggregated proteins may play a key role in prevention PD.…”
Section: Discussionmentioning
confidence: 99%
“…Previous research showed that PD is linked with the accumulation of intracellular inclusions known as Lewy bodies under stressful conditions and lessened UPS activity [ 59 ] and autophagy function [ 60 ]. Thus, augmenting the UPS or autophagy with the resultant degradation of misfolded and aggregated proteins may play a key role in prevention PD.…”
Section: Discussionmentioning
confidence: 99%
“…FOXO1 has been reported to act as a tumor suppressor for MM (76). The activation of FOXO1 could subsequently inhibit the tumor growth and induce cell autophagy and cell death (77)(78)(79)(80). FOXO3, another family member of the FOXO family, has been studied in MM (81).…”
Section: Discussionmentioning
confidence: 99%
“…The main pathological finding includes an abnormal α-synuclein accumulation bound to ubiquitin in the damaged central nerve cells, which is termed as Lewy body (LB) [96,97]. Immunostaining and Western blot analysis using the brains of normal controls and patients with PD and dementia with Lewy body (DLB) revealed that sestrin3 is present in brainstem-type LBs, suggesting that autophagy modulators like sesestrin3 are incorporated into LBs and that the expression of these proteins can be increased by various factors including aging [98]. Another study reported elevated expression of sestrin2 in the midbrain of patients with PD [99].…”
Section: Potential Roles Of Sestrins In Neurological Disorders Andmentioning
confidence: 99%