Autophagy is required to prevent early pro-inflammatory responses and neutrophil recruitment duringMycobacterium tuberculosisinfection without affecting pathogen replication in macrophages
Abstract:The immune response to Mycobacterium tuberculosis infection determines tuberculosis disease outcomes, yet we have an incomplete understanding of what immune factors contribute to a protective immune response. Neutrophilic inflammation has been associated with poor disease prognosis in humans and in animal models during M. tuberculosis infection and, therefore, must be tightly regulated. ATG5 is an essential autophagy protein that is required in innate immune cells to control neutrophil-dominated inflammation a… Show more
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