Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells

Thomas, Mark; Davis, Tanja Andrea; Loos, Ben; Sishi, Balindiwe J.N.; Huisamen, Barbara; Strijdom, Hans; Engelbrecht, Anna‐Mart

doi:10.1002/cbf.3318

Cited by 35 publications

(20 citation statements)

References 48 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thomas and colleagues demonstrated that amino acid levels in starved breast cancer cells increased with activated autophagy, whereas normal cells maintained amino acid levels under starvation. It is hypothesized that this is due to the high nutrient demand to maintain the proliferation rates of the cancer cells [134]. While this study was not in CRC this underscores the importance of understanding how autophagy is used for nutrient acquisition.…”

Section: Autophagic Substratesmentioning

confidence: 97%

Functions and Implications of Autophagy in Colon Cancer

Devenport

Shah

2019

Cells

View full text Add to dashboard Cite

Autophagy is an essential function to breakdown cellular proteins and organelles to recycle for new nutrient building blocks. In colorectal cancer, the importance of autophagy is becoming widely recognized as it demonstrates both pro- and anti-tumorigenic functions. In colon cancer, cell autonomous and non-autonomous roles for autophagy are essential in growth and progression. However, the mechanisms downstream of autophagy (to reduce or enhance tumor growth) are not well known. Additionally, the signals that activate and coordinate autophagy for tumor cell growth and survival are not clear. Here, we highlight the context- and cargo-dependent role of autophagy in proliferation, cell death, and cargo breakdown.

show abstract

Section: Autophagic Substratesmentioning

confidence: 97%

Functions and Implications of Autophagy in Colon Cancer

Devenport

Shah

2019

Cells

View full text Add to dashboard Cite

show abstract

“…In the early stages of cancer progression, autophagy acts as a tumor suppressor by removing damaged proteins and organelles, inhibiting inflammation, limiting genomic instability, inducing stress, and suppressing ROS production by the mitochondria (Lim and Murthy, 2020;Yun et al, 2020). In contrast, when tumors are already established, autophagy promotes cancer cell survival and growth by reprogramming metabolism, promoting angiogenesis, and promoting hypoxia and oxidative stress (Das et al, 2018;Thomas et al, 2018). Given that autophagy plays a role in enhancing tumor cell death, initiation of autophagy may be an attractive strategy for anticancer therapies.…”

Section: Autophagy Triggeringmentioning

confidence: 99%

Icariside II: Anticancer Potential and Molecular Targets in Solid Cancers

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Icariside II, an active flavonoid, is extracted from the traditional Chinese medicinal herb Epimedii. It possesses multiple biological and pharmacological properties, including anti-inflammatory, anticancer, and anti-osteoporotic properties. In recent years, apoptosis has become the hot spot in anticancer therapies. Icariside II exerts positive effects on inducing apoptosis and inhibiting proliferation in various cancers. The antitumorigenic activity of Icariside II was also proven through cell cycle arrest, triggering autophagy, reducing cellular metabolism, and inhibiting cancer metastasis and tumor-associated angiogenesis. Additionally, Icariside II, as a natural product, contributed to a synergistic effect alongside chemotherapeutic drugs. Due to its poor aqueous solubility and permeability, more strategies were developed to improve its therapeutic effects. This review aimed to summarize the chemopreventive properties of Icariside II in solid tumors and reveal its underlying molecular mechanisms.

show abstract

“…Cancer cells seem to activate autophagy to sustain high proliferation level that require high ATP demand. Cytotoxic and metabolic stresses, such as hypoxia and nutrient deprivation, can activate autophagy to recycle cellular components to sustain survival of cancer cells [37,39,40]. Elevated levels of autophagy have been observed in many tumors.…”

Section: Role Of Autophagy In Cancer Diseasesmentioning

confidence: 99%

Targeting Autophagy in Breast Cancer

Cocco

Leone

Piezzo

et al. 2020

IJMS

View full text Add to dashboard Cite

Breast cancer is a heterogeneous disease consisting of different biological subtypes, with differences in terms of incidence, response to diverse treatments, risk of disease progression, and sites of metastases. In the last years, several molecular targets have emerged and new drugs, targeting PI3K/Akt/mTOR and cyclinD/CDK/pRb pathways and tumor microenvironment have been integrated into clinical practice. However, it is clear now that breast cancer is able to develop resistance to these drugs and the identification of the underlying molecular mechanisms is paramount to drive further drug development. Autophagy is a highly conserved homeostatic process that can be activated in response to antineoplastic agents as a cytoprotective mechanism. Inhibition of autophagy could enhance tumor cell death by diverse anti-cancer therapies, representing an attractive approach to control mechanisms of drug resistance. In this manuscript, we present a review of autophagy focusing on its interplay with targeted drugs used for breast cancer treatment.

show abstract

Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells

Cited by 35 publications

References 48 publications

Functions and Implications of Autophagy in Colon Cancer

Functions and Implications of Autophagy in Colon Cancer

Icariside II: Anticancer Potential and Molecular Targets in Solid Cancers

Targeting Autophagy in Breast Cancer

Contact Info

Product

Resources

About