Abstract:Amino acid insufficiency activates general control nonderepressible 2 (GCN2), resulting in preferential synthesis of Activating Transcription Factor 4 (ATF4) to promote cellular protection and recovery. Asparaginase is an enzyme which breaks down asparagine and glutamine and is used to treat acute lymphoblastic leukemia in children and adults. Patients who are overweight or obese carry greater risk of developing hepatotoxicity during treatment and we reported that diet‐induced obesity predisposes mice to liver… Show more
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