Autophagy is deficient in nasal polyps: implications for the pathogenesis of the disease

Abstract

Autophagy is deficient presumably due to suppression by high Akt-mTOR activity in nasal polyps, which may provide a molecular basis for future mechanistic study of the disease.

Autophagy deficiency in myeloid cells exacerbates eosinophilic inflammation in chronic rhinosinusitis

“…Recent reports provide some clues concerning the potential role of autophagy in patients with CRS by demonstrating autophagy deficiency in NPs and its inverse correlation with COX-2 expression. 20,21 However, no study has sought to assess the direct role of autophagy in the development of CRS, especially ECRS. In the present study we obtained evidence indicating that autophagy deficiency in myeloid cells, particularly macrophages, is linked to PGD 2 dysregulation and eosinophilic inflammation in a murine model of ECRS.…”

Interferon‐γ‐induced insufficient autophagy contributes to p62‐dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps

“…In asthma, genetic polymorphisms in the autophagy genes can increase the susceptibility of airway epithelial cells to the severe respiratory viral infection . Very recently, three preliminary studies have reported conflicting results regarding the autophagy status in nasal polyp‐derived fibroblast, arguing for further investigations on the role of autophagy in the pathogenesis of CRS …”

“…9 Very recently, three preliminary studies have reported conflicting results regarding the autophagy status in nasal polyp-derived fibroblast, arguing for further investigations on the role of autophagy in the pathogenesis of CRS. [11][12][13] In mammals, the conversion of autophagic effector protein microtubule-associated protein 1 light chain 3B (LC3B) from LC3B-I (free form) to LC3B-II (membrane-bound lipidated form) is a critical step in the induction of autophagy. Therefore, LC3B-II serves as a widely used marker of the autophagosome.…”

Expression of decorin in intestinal tissues of mice with inflammatory bowel disease and its correlation with autophagy

“…Autophagy is an important cellular pathway for the maintenance of homeostasis. It degrades damaged organelles, misfolded proteins and damaged DNA to provide energy that allows the cells to respond to adverse environments (11,12). Autophagy is closely associated with inflammation (13) and is induced by a variety of inflammatory factors.…”