1999
DOI: 10.1006/mcne.1999.0780
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Autophagy Is Activated by Apoptotic Signalling in Sympathetic Neurons: An Alternative Mechanism of Death Execution

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Cited by 417 publications
(370 citation statements)
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“…During apoptosis, mitochondria are acknowledged as a central element; recently, some reports have suggested the involvement of mitochondria in autophagy also. [16][17][18][19] Here, we report for the first time, the occurrence of autophagy as a consequence of a physiological mitochondrial dysfunction in yeast, resulting from either anaerobic and heat stress growth of a FMC1 null mutant or anaerobic growth of a strain carrying a point mutation in the ATP2 gene. This mitochondrial dysfunction results in the collapse of the electrical potential across the mitochondrial inner membrane (DC), while not decreasing the cellular ATP concentration.…”
Section: Introductionmentioning
confidence: 86%
“…During apoptosis, mitochondria are acknowledged as a central element; recently, some reports have suggested the involvement of mitochondria in autophagy also. [16][17][18][19] Here, we report for the first time, the occurrence of autophagy as a consequence of a physiological mitochondrial dysfunction in yeast, resulting from either anaerobic and heat stress growth of a FMC1 null mutant or anaerobic growth of a strain carrying a point mutation in the ATP2 gene. This mitochondrial dysfunction results in the collapse of the electrical potential across the mitochondrial inner membrane (DC), while not decreasing the cellular ATP concentration.…”
Section: Introductionmentioning
confidence: 86%
“…Since apoptosis is associated with an increase in mitochondrial permeability, it is not entirely surprising that mitophagy is observed in cells that subsequently die by apoptosis in several mammalian cell systems. 7,8,43 Sympathetic neurons die within a few days after nerve growth factor (NGF) withdrawal and the cell death is characterized by an early increase in autophagosomes containing the mitochondria and other cytoplasmic components, followed by degradation of organelles within the autophagosome. 7 The classical features of apoptosis appear at later time points.…”
Section: Factors That Increase Mitochondrial Permeability Promote Degmentioning
confidence: 99%
“…7,8,43 Sympathetic neurons die within a few days after nerve growth factor (NGF) withdrawal and the cell death is characterized by an early increase in autophagosomes containing the mitochondria and other cytoplasmic components, followed by degradation of organelles within the autophagosome. 7 The classical features of apoptosis appear at later time points. Inhibition of autophagy using 3-methyladenine (3-MA, an inhibitor of Class III PI3 kinase) also blocks apoptosis with overlapping dose-response curves, suggesting that there may be a common signaling pathway that activates both autophagy and apoptosis.…”
Section: Factors That Increase Mitochondrial Permeability Promote Degmentioning
confidence: 99%
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