Autophagy in cardiovascular diseases: role of noncoding RNAs

Gao, Jinling; Chen, Xiatian; Shan, Chan; Wang, Yin; Li, Peifeng; Shao, Kai

doi:10.1016/j.omtn.2020.10.039

Cited by 29 publications

(26 citation statements)

References 142 publications

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“…In addition, the recent clinical relevance of ncRNAs in CVDs has been discussed in detail in a published report. 149 Although the overall understanding of ncRNAs is in its infancy, it is believed that with continuous exploration of the mechanism by which ncRNAs regulate pyroptotic pathways, ncRNAs could serve as a promising therapeutic strategy for pyroptosis-related CVDs.…”

Section: Pyroptosis As a Therapeutic Target In Cvdsmentioning

confidence: 99%

Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAs

Gao

Chen

Wei

et al. 2021

Molecular Therapy - Nucleic Acids

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Cardiovascular disease (CVD) is one of the most important diseases endangering human life. The pathogenesis of CVDs is complex. Pyroptosis, which differs from traditional apoptosis and necrosis, is characterized by cell swelling until membrane rupture, resulting in the release of cell contents and activation of a strong inflammatory response. Recent studies have revealed that inflammation and pyroptosis play important roles in the progression of CVDs. Noncoding RNAs (ncRNAs) are considered promising biomarkers and potential therapeutic targets for the diagnosis and treatment of various diseases, including CVDs. Growing evidence has revealed that ncRNAs can mediate the transcriptional or posttranscriptional regulation of pyroptosis-related genes by participating in the pyroptosis regulatory network. The role and molecular mechanism of pyroptosis-regulating ncRNAs in cardiovascular pathologies are attracting increasing attention. Here, we summarize research progress on pyroptosis and the role of ncRNAs, particularly microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of pyroptosis in CVD pathologies. Identifying these disease-related ncRNAs is important for understanding the pathogenesis of CVDs and providing new targets and ideas for their prevention and treatment.Noncoding RNAs (ncRNAs) account for up to 98%-99% of the human genome and participate in regulating the expression of protein-coding genes. 10,11 The interaction between ncRNAs and protein-coding genes forms a highly complex RNA regulatory network. Abnormalities in ncRNAs are closely related to numerous diseases. Recent efforts to identify the molecular mechanisms underlying the pathogenesis of CVDs have revealed a significant regulatory role of ncRNAs in the occurrence and development of major CVDs, such as myocardial infarction, coronary heart disease, atrial fibrillation, atherosclerosis, cardiomyopathy, and heart failure. [12][13][14] The main classes of ncRNAs are microRNAs (miRNAs), long ncRNAs

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Section: Pyroptosis As a Therapeutic Target In Cvdsmentioning

confidence: 99%

Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAs

Gao

Chen

Wei

et al. 2021

Molecular Therapy - Nucleic Acids

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“… 81 Additionally, miRNAs and long noncoding RNAs (lncRNAs) can be regulated by autophagy, including plasmacytoma variant translocation 1 (PVT1). 82 , 83 Although the mechanism is unknown, the elevation of PVT1 mediated by autophagy has an important function in the development and progression of diabetic nephropathy. 82 , 84 As another important type of noncoding RNA, circRNA expression is also most likely regulated by autophagy, at least during its back-splicing generation process, which may result in the impairment of circRNA functions in human physiology and pathology, including cancer.…”

Section: Autophagy-related Circrna In Cancermentioning

confidence: 99%

Circular RNAs act as regulators of autophagy in cancer

Zhou

Zhang²,

Gao³

et al. 2021

Molecular Therapy - Oncolytics

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Circular RNAs (circRNAs) are a large class of noncoding RNAs that are emerging as critical regulators of various cellular processes that are involved in the physiopathological mechanism of many human diseases, such as cardiovascular disease, atherosclerosis, diabetes mellitus, and carcinogenesis. Autophagy is a conserved and catabolic cellular process that degrades unfolded, misfolded, or damaged protein aggregates or organelles to maintain cellular homeostasis under physiological and pathological conditions. Increasing evidence has shown a link between circRNAs and autophagy that is closely related to the occurrence and development of human diseases, including cancer. In this review, we highlight recent advances in understanding the functions and mechanisms of circRNAs in the regulation of autophagy in cancer. These autophagy-related circRNAs contribute to cancer development and progression in various types of human cancer by activating or inhibiting autophagy. Cumulative research on the relationship between circRNAs and autophagy regulation provides critical insight into the essential role that circRNAs play in carcinogenesis and suggests new targets for tumor therapy.

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“…Although increasing attention has been put on exploring the therapeutic potential of miRNA to treat CVDs, not enough research has been done on other ncRNA types, such as lncRNA. LncRNA has been closely associated with pathways, such as autophagy regulation, proliferation, apoptosis [ 160 ]—all of which have implications in CVDs, indicate the plausible role of lncRNAs in CVDs. In order to establish an association between lncRNAs and CVDs, we have previously demonstrated the differential regulation of several lncRNAs in ECs following treatment with atherosclerosis-associated oxLDL and pravastatin [ 161 ]; diabetes-associated high glucose [ 162 ]; inflammation-associated lipopolysaccharides; and fibrosis-associated TGFβ [ 163 ].…”

Section: Therapeutic Potential Of Ncrna In Cvdsmentioning

confidence: 99%

Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology

Bu¹,

Singh²

2021

IJMS

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Cardiovascular diseases (CVDs) are the number one cause of debilitation and mortality worldwide, with a need for cost-effective therapeutics. Autophagy is a highly conserved catabolic recycling pathway triggered by various intra- or extracellular stimuli to play an essential role in development and pathologies, including CVDs. Accordingly, there is great interest in identifying mechanisms that govern autophagic regulation. Autophagic regulation is very complex and multifactorial that includes epigenetic pathways, such as histone modifications to regulate autophagy-related gene expression, decapping-associated mRNA degradation, microRNAs, and long non-coding RNAs; pathways are also known to play roles in CVDs. Molecular understanding of epigenetic-based pathways involved in autophagy and CVDs not only will enhance the understanding of CVDs, but may also provide novel therapeutic targets and biomarkers for CVDs.

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Autophagy in cardiovascular diseases: role of noncoding RNAs

Cited by 29 publications

References 142 publications

Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAs

Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAs

Circular RNAs act as regulators of autophagy in cancer

Epigenetic Regulation of Autophagy in Cardiovascular Pathobiology

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