Autophagy as a self-digestion signal in human cancers: Regulation by microRNAs in affecting carcinogenesis and therapy response

Kadhim, Mustafa M.; Ramírez‐Coronel, Andrés Alexis; Jalil, Abduladheem Turki; Talib, Hayder Abdullah; Gupta, Jitendra; Jawhar, Zanko Hassan; Saleh, Mawan Mahmood; Pandey, Vijay; Zhang, Xi; Khan, Haroon

doi:10.1016/j.phrs.2023.106695

Cited by 7 publications

(1 citation statement)

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“…NDRG2 has been identified as a regulator of ferroptosis in cholangiocarcinoma cells, inhibiting tumor growth and increasing the sensitivity of radiotherapy [125][126][127]. Yao X et al established a prognostic model for cholangiocarcinoma using public databases, which included four ferroptosis-related genes: ACSL4, IREB2, NFE2L2, and TP53 [128].…”

Section: Cholangiocarcinomamentioning

confidence: 99%

Ferroptosis and cancer: interlinkages and potential applications

Hu¹,

Jiang²

2023

Clin. transl. rep.

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The buildup of lipid peroxides on the cell membrane is critical in the initiation of Ferroptosis, an iron-dependent form of controlled cell death. Ferroptosis is a type of cell death that varies from other types of cell death in both mechanics and morphology, and it holds significant promise for cancer therapy. As a result, there has been increasing interest in the cancer research community regarding the exploration and understanding of Ferroptosis in recent years. This review article aims to provide a solid theoretical foundation for the management of Ferroptosis in cancer. It accomplishes this by summarizing the processes that contribute to the development of Ferroptosis and outlining the underlying mechanisms of Ferroptosis in various types of tumors.

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