Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapy

Ashrafizadeh, Milad; Mohammadinejad, Reza; Tavakol, Shima; Ahmadi, Zahra; Roomiani, Sahar; Katebi, Majid

doi:10.1002/jcp.28740

Cited by 94 publications

(74 citation statements)

References 100 publications

(117 reference statements)

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“…18 Complementary processes that inhibit cell replication include anoikis, which is anchorage loss-dependent death; necroptosis, which is a caspase-independent, inflammatory cell death; ferroptosis, which is an iron-dependent oxidative cell death; and senescence, which is irreversible cell cycle inhibition coupled with the secretion of cytokines, growth factors and proteases. 24,25 There is considerable interest in finding therapeutics that disrupt many of these processes and the reader is directed to some useful reviews for further details. 26,27…”

Section: Tumor Addiction To Oncogenesmentioning

confidence: 99%

The hubris and humility of cancer pharmacology in the post immuno‐oncology era

Lazo

2019

Pharmacology Res & Perspec

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Cancer is a dreaded word, which has stimulated monumental efforts to discover and deliver effective cancer treatments for more than half a century. During the past two decades, our understanding of the molecular pathogenesis of cancer has increased remarkably. This has fostered an explosion in the number of experimental agents and clinical trials coupled with a dramatic rise in the regulatory approval of therapies for human cancers. Unfortunately, our preclinical models perform poorly as predictive platforms for the ultimate success of clinical candidates, reflecting the complexity of cancer. Moreover the common combination of cancer drugs prescribes the need for a better understanding of the fundamental pharmacology of each agent. Here I briefly outline some of the fundamental changes that have and have not occurred in cancer pharmacology during the past two decades and prognosticate on possible future directions.

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Section: Tumor Addiction To Oncogenesmentioning

confidence: 99%

The hubris and humility of cancer pharmacology in the post immuno‐oncology era

Lazo

2019

Pharmacology Res & Perspec

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“…So, there is a need for developing new anticancer drugs to be used with conventional and newly introduced anticancer drugs for targeting multiple signaling pathways and making a reduction in the viability of cancer cells. It seems that plant‐derived chemicals with high antitumor activity are of interest due to their minimal side effects and multitargeting (Ashrafizadeh, Ahmadi, Farkhondeh, & Samarghandian, ; Ashrafizadeh et al, ; Ashrafizadeh et al, ; Khoshakhlagh et al, ; Soleimani et al, ; Soleimani et al, ; Tavakol et al, ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs as novel targets of sulforaphane in cancer therapy: The beginning of a new tale?

Rafiei

Ashrafizadeh

Ahmadi

2020

Phytotherapy Research

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Effective management and treatment of cancer depend on developing novel antitumor drugs with the capability of targeting various molecular pathways. Identification and subsequent targeting of these pathways are of importance in cancer therapy. MicroRNAs (miRNAs) are small noncoding RNA molecules responsible for post‐transcriptional regulation of genes. Notably, miRNAs participate in a number of biological processes such as proliferation, apoptosis, differentiation, and cell cycle regulation. So, any impairment in the expression and function of miRNAs is associated with development of disorders, particularly cancer. Naturally occurring nutraceutical compounds have attracted much attention due to their great antitumor activity. Among them, sulforaphane isolated from Brassica oleracea (broccoli) is of interest due to its therapeutic and biological activities such as antidiabetic, antioxidant, anti‐inflammatory, hepatoprotection, and cardiprotection. Sulforaphane has demonstrated great antitumor activity and is able to significantly inhibit proliferation, viability, migration, malignancy, and epithelial‐to‐mesenchymal transition of cancer cells. These antitumor effects have widely been investigated, and it appears that there is a need for a precise review to demonstrate the molecular pathway that sulforaphane follows to exert its antitumor activity. At the present review, we focus on the modulatory impact of sulforaphane on miRNAs and exhibit that how various miRNAs in different cancers are regulated by sulforaphane.

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“…Autophagy is activated in stress conditions, such as nutrient deprivation, oxidative stress, and so on, as an adaptation process (Rabiee et al, ). There are several studies that show the crucial role of autophagy in pathological conditions such as cancer, infection, aging, heart disease, and neurodegeneration (Ashrafizadeh et al, ). The main kind of autophagy is macroautophagy (simply as “autophagy”) that a number of strongly regulated series of interactions between more than 10 various proteins are involved to form a double‐membrane vesicle naming “autophagosome.” Autophagosome is formed through the elongation and sealing of a de novo generated membrane (Ashrafizadeh et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…There are several studies that show the crucial role of autophagy in pathological conditions such as cancer, infection, aging, heart disease, and neurodegeneration (Ashrafizadeh et al, ). The main kind of autophagy is macroautophagy (simply as “autophagy”) that a number of strongly regulated series of interactions between more than 10 various proteins are involved to form a double‐membrane vesicle naming “autophagosome.” Autophagosome is formed through the elongation and sealing of a de novo generated membrane (Ashrafizadeh et al, ). Following, autophagosome is fused into lysosome and is sequestered into its residues including fatty acids, amino acids, sugars, nucleotides, and other elements to recycle and reentry toward biosynthesis (White, Mehnert, & Chan, ).…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

Ashrafizadeh

Tavakol

Ahmadi

et al. 2019

Phytotherapy Research

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Regulated cell death (RCD) guarantees to preserve organismal homeostasis. Apoptosis and autophagy are two major arms of RCD, while endoplasmic reticulum (ER) as a crucial organelle involved in proteostasis, promotes cells toward autophagy and apoptosis. Alteration in ER stress and autophagy machinery is responsible for a great number of diseases. Therefore, targeting those pathways appears to be beneficial in the treatment of relevant diseases. Meantime, among the traditional herb medicine, kaempferol as a flavonoid seems to be promising to modulate ER stress and autophagy and exhibits protective effects on malfunctioning cells. There are some reports indicating the capability of kaempferol in affecting autophagy and ER stress. In brief, kaempferol modulates autophagy in noncancerous cells to protect cells against malfunction, while it induces cell mortality derived from autophagy through the elevation of p-AMP-activated protein kinase, light chain-3-II, autophagy-related geness, and Beclin-1 in cancer cells. Noteworthy, kaempferol enhances cell survival through C/EBP homologous protein (CHOP) suppression and GRP78 increment in noncancerous cells, while it enhances cell mortality through the induction of unfolding protein response and CHOP increment in cancer cells. In this review, we discuss how kaempferol modulates autophagy and ER stress in noncancer and cancer cells to expand our knowledge of new pharmacological compounds for the treatment of associated diseases. K E Y W O R D S apoptosis, autophagy, cell death, endoplasmic reticulum stress, flavonoid, kaempferol

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Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapy

Cited by 94 publications

References 100 publications

The hubris and humility of cancer pharmacology in the post immuno‐oncology era

The hubris and humility of cancer pharmacology in the post immuno‐oncology era

MicroRNAs as novel targets of sulforaphane in cancer therapy: The beginning of a new tale?

Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

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