Autophagy and oxidative stress associated with gold nanoparticles

Li, Jasmine J.; Hartono, Deny; Ong, Choon Nam; Bay, Boon‐Huat; Yung, Lin‐Yue Lanry

doi:10.1016/j.biomaterials.2010.04.014

Cited by 455 publications

(305 citation statements)

References 36 publications

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“…Gold nanoparticles (AuNPs) in MRC-5 human lung fibroblasts induced autophagy with oxidative stress [119]. In a study, the cellular motility was used to demonstrate the cytotoxicity of metal and semiconductor nanoparticles on animal cells.…”

Section: Effects On Cell Linesmentioning

confidence: 99%

“…In vitro studies have revealed CNTs disrupt the membrane potential, membrane integrity, metabolic activity and cellular reproduction [137,138]. Gold nanoparticles are responsible for mitochondrial damage, affecting cellular micro mobility, autophagy and oxidative stress [119,139]. In vitro studies on silver nanoparticles' toxicity have suggested that interference with DNA replication, fidelity, apoptosis, oxidative stress, cytotoxicity, chromosome instability, intracellular calcium transients, JNK activation and cell cycle arrest in mammalian cells [121-125, 140, 141].…”

Section: Mechanistic Studiesmentioning

confidence: 99%

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In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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Section: Effects On Cell Linesmentioning

confidence: 99%

Section: Mechanistic Studiesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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“…Typically, two membranes will be formed surrounding the region where the nanoparticles are located, to separate this region from the rest of the cytoplasm and then fuse with lysosomes in order to reduce cellular stress and degrade the particles [91]. Also gold nanoparticles, which are generally seen as quite biocompatible, induce oxidative stress upon cellular internalization which in turn activates autophagy [92].…”

Section: Mitotic Partitioning Of Inorganic Quantum Dots Gold and Iromentioning

confidence: 99%

Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis

Symens

Soenen

Rejman

et al. 2012

Advanced Drug Delivery Reviews

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“…Li et al [57] found that gold nanoparticles (AuNPs) induce autophagy in human lung fibroblasts MRC-5 cells. They have observed the formation of autophagosomes, as well as upregulation of autophagy-related proteins (LC3, Atg7).…”

Section: Gold Nanomaterialsmentioning

confidence: 99%

Autophagy as new emerging cellular effect of nanomaterials

et al. 2013

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The biosafety issue of nanoscale materials is getting more and more attention with their increasing manufacture and application. In the research of cellular effects and underlying mechanisms related to toxicity of nanomaterials, most emphasis were placed on processes such as apoptosis, metabolic inhibition and oxidative stress. Recent evidence suggests that autophagy is part of the biological effects by nanomaterials and various kinds of nanomaterials are capable of disturbing the autophagic process. This review will highlight the importance of autophagy as an emerging mechanism of nanomaterial toxicity and the implication in the therapy of autophagy-related diseases. We summarize current research status of interaction between nanomaterials and autophagic pathways. It is of note that nanomaterials can either induce or block autophagy, which result in similar phenotype but completely different biological consequence. It is therefore important to perform comprehensive analysis of the whole autophagic flux in the future research. Nanomaterials refer to materials with the size range between 1 and 100 nanometers in one or more dimensions [1]. Due to their superior physicochemical properties, such as ultra small size, increased ratio of surface area to volume, multiple options for modification and relatively good biocompatibilities, application of nanomaterials in research as well as in industry becomes more and more common. It is predicted that the total amount of nanomaterials' production will increase up to 58000 tons by 2020. Particularly, the utilization of nanomaterials in biomedical research as biosensors, drug-carriers, or imaging agents was extensively studied [2][3][4]. Large scaled preparation and application of nanomaterials increase their possibilities to be exposed to human beings or enter the environment [5][6][7]. Therefore the impact of nanomaterials on environment and human health has attracted high attention. Related studies were carried out on the biological effect of various kinds of nanomaterials both in vitro and in vivo [8]. To date, reported physiological changes of a cell or an organism that exposed to nanomaterials include: reactive oxygen species (ROS)-related pathological responses (such as damaged membrane, mitochondrial damage and necrosis), apoptosis, inflammation and altered differentiation patterns, etc [9][10][11][12]. Recently, autophagy as an essential cellular process and a novel biological effect of nanomaterials on eukaryotes, has received much attention. Many nanomaterials were reported to be able to change the basal level of autophagy [13,14]. Autophagy can crosstalk with other cellular process, such as apoptosis and necrosis, and therefore is an important part of the cellular effect of nanomaterials [15,16]. Moreover, nanomaterials-induced autophagy showed potential for the treatment of certain diseases including neurodegenerative diseases and cancer [13,17]. Hence, in this review we summarize the current research on the effect of various kinds of nanomaterials on autophagy. ...

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Autophagy and oxidative stress associated with gold nanoparticles

Cited by 455 publications

References 36 publications

In vitro and in vivo toxicity assessment of nanoparticles

In vitro and in vivo toxicity assessment of nanoparticles

Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis

Autophagy as new emerging cellular effect of nanomaterials

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