Autophagic degradation of CDK4 is responsible for G0/G1 cell cycle arrest in NVP-BEZ235-treated neuroblastoma
Zhen Liu,
Xiao-Yang Wang,
Han-Wei Wang
et al.
Abstract:Background
CDK4 is highly expressed and associated with poor prognosis and decreased survival in advanced neuroblastoma (NB). Targeting CDK4 degradation presents a potentially promising therapeutic strategy compared to conventional CDK4 inhibitors. However, the autophagic degradation of the CDK4 protein and its anti-proliferation effect in NB cells has not been mentioned.
Results
We identified autophagy as a new pathway for the degradation of CDK4. Firstly, autophagic d… Show more
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