Autonomous self-healing of poly(acrylic acid) hydrogels induced by the migration of ferric ions

Wei, Zengjiang; He, Jie; Liang, Tony W.; Oh, Hyun‐Taek; Athas, Jasmin; Tong, Zhen; Wang, Chaoyang; Nie, Zhihong

doi:10.1039/c3py00692a

Cited by 257 publications

(194 citation statements)

References 29 publications

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“…[40,41] In addition, the G′ values of PACG35-GelMA7-BG hydrogels are much larger than those of PACG10-GelMA10-Mn 2+ hydrogels, which is consistent with the results of mechanical test above. [42,43] This quick recovery capability owned by PACG10-GelMA10-Mn 2+ and PACG35-GelMA7-BG make them ideal inks for printing gradient scaffold for treating osteochondral defect. Under the small shear strain (10%), the G′ of the gel is larger than G″, showing a typical elastic solid characterisitic.…”

Section: Preparation and Characterization Of Pacg-gelma-mn 2+ And Pacmentioning

confidence: 99%

Osteochondral Regeneration with 3D‐Printed Biodegradable High‐Strength Supramolecular Polymer Reinforced‐Gelatin Hydrogel Scaffolds

et al. 2019

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Biomacromolecules with poor mechanical properties cannot satisfy the stringent requirement for load‐bearing as bioscaffolds. Herein, a biodegradable high‐strength supramolecular polymer strengthened hydrogel composed of cleavable poly( N ‐acryloyl 2‐glycine) (PACG) and methacrylated gelatin (GelMA) (PACG‐GelMA) is successfully constructed by photo‐initiated polymerization. Introducing hydrogen bond‐strengthened PACG contributes to a significant increase in the mechanical strengths of gelatin hydrogel with a high tensile strength (up to 1.1 MPa), outstanding compressive strength (up to 12.4 MPa), large Young's modulus (up to 320 kPa), and high compression modulus (up to 837 kPa). In turn, the GelMA chemical crosslinking could stabilize the temporary PACG network, showing tunable biodegradability by adjusting ACG/GelMA ratios. Further, a biohybrid gradient scaffold consisting of top layer of PACG‐GelMA hydrogel‐Mn 2+ and bottom layer of PACG‐GelMA hydrogel‐bioactive glass is fabricated for repair of osteochondral defects by a 3D printing technique. In vitro biological experiments demonstrate that the biohybrid gradient hydrogel scaffold not only supports cell attachment and spreading but also enhances gene expression of chondrogenic‐related and osteogenic‐related differentiation of human bone marrow stem cells. Around 12 weeks after in vivo implantation, the biohybrid gradient hydrogel scaffold significantly facilitates concurrent regeneration of cartilage and subchondral bone in a rat model.

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Section: Preparation and Characterization Of Pacg-gelma-mn 2+ And Pacmentioning

confidence: 99%

Osteochondral Regeneration with 3D‐Printed Biodegradable High‐Strength Supramolecular Polymer Reinforced‐Gelatin Hydrogel Scaffolds

et al. 2019

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“…Such increasing attention to the development of novel self-healable materials is attributed to their built-in ability to repair physical damages, effectively preventing such as π-π stacking, [ 6,7 ] ionic interaction, [ 8 ] metal-ion binding, [ 9 ] hydrogen bonding, [ 10 ] host-guest interactions, [ 11 ] and redox. [ 12 ] In contrast, the use of reversible covalent bond formation can provide higher mechanical strength and higher stability for self-healing materials.…”

Section: Introductionmentioning

confidence: 99%

Dual Sulfide–Disulfide Crosslinked Networks with Rapid and Room Temperature Self‐Healability

Noh

Nam

et al. 2015

Macromol. Rapid Commun.

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Polymer-based crosslinked networks with intrinsic self-repairing ability have emerged due to their built-in ability to repair physical damages. Here, novel dual sulfide-disulfide crosslinked networks (s-ssPxNs) are reported exhibiting rapid and room temperature self-healability within seconds to minutes, with no extra healing agents and no change under any environmental conditions. The method to synthesize these self-healable networks utilizes a combination of well-known crosslinking chemistry: photoinduced thiol-ene click-type radical addition, generating lightly sulfide-crosslinked polysulfide-based networks with excess thiols, and their oxidation, creating dynamic disulfide crosslinkages to yield the dual s-ssPxNs. The resulting s-ssPxN networks show rapid self-healing within 30 s to 30 min at room temperature, as well as self-healing elasticity with reversible viscoelastic properties. These results, combined with tunable self-healing kinetics, demonstrate the versatility of the method as a new means to synthesize smart multifunctional polymeric materials.

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“…So far, robots do not have healing abilities. To the best of the authors' knowledge, only one paper by Hunt et al [6] can be found in which a SH-principle is used to create a SH-dielectric elastomer 1 actuator and in a publication of Wei et al [7] it is suggested to use a SH-hydrogel in future soft robotics applications. The introduction of SH-materials in robotics has potential to tackle three problems, described in the following three paragraphs.…”

Section: Introductionmentioning

confidence: 99%

Investigation of self-healing compliant actuators for robotics

Terryn

Mathijssen

Brancart

et al. 2015

2015 IEEE International Conference on Robotics and Automation (ICRA)

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Last 15 years, a wide range of self-healing (SH) materials has been developed and recently these materials are increasingly used in applications in multiple fields, like the automotive industry and aerospace. However, so far this material technology is not yet explored in robotics. The introduction of these materials in robotics will potentially reduce the over-dimensioning of current robotic systems, leading to lighter systems and eventually to more efficient designs. Compliant elements used in next generation soft robots, can be constructed from available SH-materials, making them able to autonomously heal cuts and perforations caused by sharp objects in unstructured environments. In addition, the use of SHmaterials will have a beneficial impact on the life span of robotic components, reducing the required maintenance drastically. This paper presents the innovative concept of implementing a SH-mechanism in compliant actuators, using dynamic covalent polymer network systems based on the reversible Diels-Alder (DA) reaction. For two entirely different compliant actuators, a series elastic actuator (SEA) and a soft pneumatic actuator (SPA), an analysis is presented on the integration of the DApolymers in the actuator designs. For both actuator types, a prototype was designed, developed and validated.

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Autonomous self-healing of poly(acrylic acid) hydrogels induced by the migration of ferric ions

Cited by 257 publications

References 29 publications

Osteochondral Regeneration with 3D‐Printed Biodegradable High‐Strength Supramolecular Polymer Reinforced‐Gelatin Hydrogel Scaffolds

Osteochondral Regeneration with 3D‐Printed Biodegradable High‐Strength Supramolecular Polymer Reinforced‐Gelatin Hydrogel Scaffolds

Dual Sulfide–Disulfide Crosslinked Networks with Rapid and Room Temperature Self‐Healability

Investigation of self-healing compliant actuators for robotics

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