Autonomous Non‐Equilibrium Self‐Assembly and Molecular Movements Powered by Electrical Energy**

Ragazzon, Giulio; Malferrari, Marco; Arduini, Arturo; Secchi, Andrea; Rapino, Stefania; Silvi, Serena

doi:10.1002/ange.202214265

“…It is important to note electric field based molecular motor and achieving high energy state in a molecular system mainly having mechanical bond based supramolecular assembly system has been reported in recent literature. [34][35][36][37][38][39] In fact, one of the recent study indicated the entropy stored in that type of system. 37 However, none of the cases, effect of further complexity by application of external electric field in transient self-assembly process as discussed here, has been reported.…”

mentioning

confidence: 99%

Electric Field-Driven Spatial Information Capture of Dissipative Biocondensate States

Saini

¹

,

Mahato

²

,

Priyanka³

et al. 2023

Preprint

0

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The theory behind origin of life to Darwinian evolution considers emergence of dissipative structures driven by the flow of energy across all length scales. To this end, developing and deeper understanding of non-equilibrium self-assembly processes under continuous supply of energy is a demanding matter, both in fundamental and application (for e.g. developing dynamic materials) viewpoint. Herein, we demonstrate transient self-assembly of a DNA-histone condensate where trypsin (already present in the system) hydrolyse histone resulting disassembly. As the process is short-lived, the information of intermediate states between complete assembly and disassembly remains uncaptured in absence of any external energy. We show that performing the process under electric field of varying strength results fractionation of myriad of short-lived states which appears as band in different zone. Deconvolution and capturing of many hidden self-assembling species of similar components but of different compositions which otherwise never be formed in absence of electric energy, will be of immense importance in applied non-equilibrium thermodynamics.

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Molecular Ratchets and Kinetic Asymmetry: Giving Chemistry Direction

Borsley,

Leigh,

Roberts

2024

Angewandte Chemie

0

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In recent years ratchet mechanisms have transformed the understanding and design of stochastic molecular systems—biological, chemical and physical—in a move away from the mechanical macroscopic analogies that dominated thinking regarding molecular dynamics in the 1990s and early 2000s (e.g. pistons, springs, etc), to the more scale‐relevant concepts that underpin out‐of‐equilibrium research in the molecular sciences today. Ratcheting has established molecular nanotechnology as a research frontier for energy transduction and metabolism, and has enabled the reverse engineering of biomolecular machinery, delivering insights into how molecules ‘walk’ and track‐based synthesizers operate, how the acceleration of chemical reactions enables energy to be transduced by catalysts, and how dynamic (supra)molecular systems can be driven away from equilibrium. The recognition of molecular ratchet mechanisms in biology, and their invention in synthetic systems, is proving significant in areas as diverse as supramolecular chemistry, systems chemistry, dynamic covalent chemistry, DNA nanotechnology, polymer and materials science, molecular biology, heterogeneous catalysis, endergonic synthesis, and many other branches of chemical science. Put simply, ratchet mechanisms give chemistry direction. Kinetic asymmetry, quantified by the outcome of ratcheting, is the dynamic counterpart of structural asymmetry (i.e. chirality). Given the ubiquity of ratchet mechanisms, it is surely just as fundamentally important.

show abstract

Molecular Ratchets and Kinetic Asymmetry: Giving Chemistry Direction

Borsley,

Leigh,

Roberts

2024

Angew Chem Int Ed

8

0

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In recent years ratchet mechanisms have transformed the understanding and design of stochastic molecular systems—biological, chemical and physical—in a move away from the mechanical macroscopic analogies that dominated thinking regarding molecular dynamics in the 1990s and early 2000s (e.g. pistons, springs, etc), to the more scale‐relevant concepts that underpin out‐of‐equilibrium research in the molecular sciences today. Ratcheting has established molecular nanotechnology as a research frontier for energy transduction and metabolism, and has enabled the reverse engineering of biomolecular machinery, delivering insights into how molecules ‘walk’ and track‐based synthesizers operate, how the acceleration of chemical reactions enables energy to be transduced by catalysts, and how dynamic (supra)molecular systems can be driven away from equilibrium. The recognition of molecular ratchet mechanisms in biology, and their invention in synthetic systems, is proving significant in areas as diverse as supramolecular chemistry, systems chemistry, dynamic covalent chemistry, DNA nanotechnology, polymer and materials science, molecular biology, heterogeneous catalysis, endergonic synthesis, and many other branches of chemical science. Put simply, ratchet mechanisms give chemistry direction. Kinetic asymmetry, quantified by the outcome of ratcheting, is the dynamic counterpart of structural asymmetry (i.e. chirality). Given the ubiquity of ratchet mechanisms, it is surely just as fundamentally important.

show abstract

Autonomous Non‐Equilibrium Self‐Assembly and Molecular Movements Powered by Electrical Energy**

Cited by 4 publications

References 68 publications

Electric Field-Driven Spatial Information Capture of Dissipative Biocondensate States

Electric Field-Driven Spatial Information Capture of Dissipative Biocondensate States

Molecular Ratchets and Kinetic Asymmetry: Giving Chemistry Direction

Molecular Ratchets and Kinetic Asymmetry: Giving Chemistry Direction

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