Autonomous glucose metabolic reprogramming of tumour cells under hypoxia: opportunities for targeted therapy

Huang, Mingyao; Yang, Liang; Peng, Xueqiang; Wei, Shibo; Fan, Qing; Yang, Shuo; Li, Xinyu; Li, Bowen; Jin, Hongyuan; Wu, Bo; Liu, Jingang; Li, Hangyu

doi:10.1186/s13046-020-01698-5

Cited by 16 publications

(10 citation statements)

References 121 publications

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“…Interestingly, developmental transcriptional factors (ORESARA 9, MORE AXILLARY BRANCHES2 (MAX2), NAC (NO APICAL MERISTEM (NAM), ATAF1, and CUP‐SHAPED COTYLEDON2 (CUC2)) are required to gain the competence for senescence. Treatment with low N and 2% glucose induced senescence in a way similar to the genetically regulated developmental senescence (Huang et al, 2020; Wingler et al, 2009; Table 2). Additionally, the cell wall invertases play a role in determining the sucrose or hexose ratio in the apoplast to influence the sink activity of the older leaves.…”

Section: Sugar Signaling Involved In Growth and Developmentmentioning

confidence: 65%

Molecular cues of sugar signaling in plants

Choudhary

Kumar

Kaur

et al. 2022

Physiologia Plantarum

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Sugars, the chemically bound form of energy, are formed by the absorption of photosynthetically active radiation and fixation in plants. During evolution, plants availed the sugar molecules as a resource, balancing molecule, and signaling molecule. The multifaceted role of sugar molecules in response to environmental stimuli makes it the central coordinator required for growth, survival, and continuity. During the course of evolution, the molecular networks have become complex to adapt or acclimate to the changing environment. Sugar molecules are sensed both intra and extracellularly by their specific sensors. The signal is transmitted by a signaling loop that involves various downstream signaling molecules, transcriptional factors and, most pertinent, the sensors TOR and SnRK1. In this review, the focus has been retained on the significance of the sugar sensors during signaling and induced modules to regulate plant growth, development, biotic and abiotic stress. It is interesting to visualize the sugar molecule as a signaling unit and not only a nutrient. Complete information on the downstream components of sugar signaling will open the gates for improving the qualitative and quantitative elements of crop plants.

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Section: Sugar Signaling Involved In Growth and Developmentmentioning

confidence: 65%

Molecular cues of sugar signaling in plants

Choudhary

Kumar

Kaur

et al. 2022

Physiologia Plantarum

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“…HIF-1α also regulates tumor growth by adjusting anaerobic and aerobic oxidation of glucose 46 . Glycolytic reprogramming is a key feature of metabolic reprogramming in tumors; thus, HIF-1α regulates glycolytic reprogramming by directly stimulating the transcription of all 12 enzymes that are necessary for glycolysis 47 , 48 .…”

Section: Role Of Hifs In Tumor Progressionmentioning

confidence: 99%

The crosstalk between HIFs and mitochondrial dysfunctions in cancer development

et al. 2021

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Mitochondria are essential cellular organelles that are involved in regulating cellular energy, metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic disease that is closely associated with mitochondrial dysfunction. Hypoxia-inducible factors (HIFs), which are major molecules that respond to hypoxia, play important roles in cancer development by participating in multiple processes, such as metabolism, proliferation, and angiogenesis. The Warburg phenomenon reflects a pseudo-hypoxic state that activates HIF-1α. In addition, a product of the Warburg effect, lactate, also induces HIF-1α. However, Warburg proposed that aerobic glycolysis occurs due to a defect in mitochondria. Moreover, both HIFs and mitochondrial dysfunction can lead to complex reprogramming of energy metabolism, including reduced mitochondrial oxidative metabolism, increased glucose uptake, and enhanced anaerobic glycolysis. Thus, there may be a connection between HIFs and mitochondrial dysfunction. In this review, we systematically discuss the crosstalk between HIFs and mitochondrial dysfunctions in cancer development. Above all, the stability and activity of HIFs are closely influenced by mitochondrial dysfunction related to tricarboxylic acid cycle, electron transport chain components, mitochondrial respiration, and mitochondrial-related proteins. Furthermore, activation of HIFs can lead to mitochondrial dysfunction by affecting multiple mitochondrial functions, including mitochondrial oxidative capacity, biogenesis, apoptosis, fission, and autophagy. In general, the regulation of tumorigenesis and development by HIFs and mitochondrial dysfunction are part of an extensive and cooperative network.

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“…Cav-1 knockout fibroblasts could stabilize HIF-1α under normal oxygen conditions by increasing reactive oxygen species in cells [81]. On the one hand, HIF1-α promotes glycolysis by regulating glucose transporters, glycolytic enzymes, and the genes that encode them [82]. Furthermore, HIF-1α may influence CAF secretion.…”

Section: Reprogramming Of the Tmementioning

confidence: 99%

Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine

Lai

Wang

Nie

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer. In cancer, the oxidative phosphorylation metabolic pathway is converted into the glycolytic pathway in order to meet the growth requirements of cancer cells, thereby creating a microenvironment that promotes cancer progression. The precise mechanism of glucose metabolism in cancer cells is still unknown, but it is thought to involve the aberrant levels of metabolic enzymes, the influence of the tumor microenvironment (TME), and the activation of tumor-promoting signaling pathways. It is suggested that glucose metabolism is strongly linked to cancer progression because it provides energy to cancer cells and interferes with antitumor drug pharmacodynamics. Therefore, it is critical to unravel the mechanism of glucose metabolism in tumors in order to gain a better understanding of tumorigenesis and to lay the groundwork for future research into the identification of novel diagnostic markers and therapeutic targets for cancer treatment. Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, multiple components, and less toxic side effects and has unique advantages in tumor treatment. In recent years, researchers have found that a variety of Chinese medicine monomers and compound recipes play an antitumor role by interfering with the reprogramming of tumor metabolism. The underlying mechanisms of metabolism reprogramming of tumor cells and the role of TCM in regulating glucose metabolism are reviewed in this study, so as to provide a new idea for antitumor research in Chinese medicine.

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Autonomous glucose metabolic reprogramming of tumour cells under hypoxia: opportunities for targeted therapy

Cited by 16 publications

References 121 publications

Molecular cues of sugar signaling in plants

Molecular cues of sugar signaling in plants

The crosstalk between HIFs and mitochondrial dysfunctions in cancer development

Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine

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