Autonomous discovery of optically active chiral inorganic perovskite nanocrystals through an intelligent cloud lab

Li, Jiagen; Li, Junzi; Liu, Rulin; Tu, Yuxiao; Li, Yiwen; Cheng, Jiaji; He, Tingchao; Zhu, Xi

doi:10.1038/s41467-020-15728-5

Cited by 99 publications

(121 citation statements)

References 51 publications

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“…20 Recently, CD has been observed in QDs and nanorods which have not been activated by chiral molecules. [26][27][28] This is surprising since observation of chiro-optic activity in randomly oriented nanoparticles requires chirality. To explain this observation the authors of Ref.…”

mentioning

confidence: 99%

Circular dichroism in non-chiral metal halide perovskites

2020

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confidence: 99%

Circular dichroism in non-chiral metal halide perovskites

2020

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“…Apapted under the terms of a Creative Commons Attribution 4.0 International License. [ 135 ] Copyright 2020, The Authors, published by Springer Nature. B) (I) Illustration of the developed microfluidic system by Bezinge et al.…”

Section: Autonomous Colloidal Nanomaterials Synthesismentioning

confidence: 99%

Accelerated Development of Colloidal Nanomaterials Enabled by Modular Microfluidic Reactors: Toward Autonomous Robotic Experimentation

2020

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Solution-processed organic, [1-3] metallic, [4-6] and semiconductor [7,8] nanomaterials, possess unique size-related physicochemical, optical, magnetic, and electronic properties. These materials have enabled groundbreaking advancements in a variety of applications including catalysis, [9-11] drug delivery, [12,13] data storage, [14] and solar cells. [15] Different nucleation and growth models such as LaMer burst nucleation, [16] Ostwald ripening, [17] Finke-Watzky two-step mechanism, [18] orientated attachment, [19] and coalescence [20] have attempted to explain the mechanisms through which nanoparticles are formed in In recent years, microfluidic technologies have emerged as a powerful approach for the advanced synthesis and rapid optimization of various solution-processed nanomaterials, including semiconductor quantum dots and nanoplatelets, and metal plasmonic and reticular framework nanoparticles. These fluidic systems offer access to previously unattainable measurements and synthesis conditions at unparalleled efficiencies and sampling rates. Despite these advantages, microfluidic systems have yet to be extensively adopted by the colloidal nanomaterial community. To help bridge the gap, this progress report details the basic principles of microfluidic reactor design and performance, as well as the current state of online diagnostics and autonomous robotic experimentation strategies, toward the size, shape, and composition-controlled synthesis of various colloidal nanomaterials. By discussing the application of fluidic platforms in recent high-priority colloidal nanomaterial studies and their potential for integration with rapidly emerging artificial intelligence-based decision-making strategies, this report seeks to encourage interdisciplinary collaborations between microfluidic reactor engineers and colloidal nanomaterial chemists. Full convergence of these two research efforts offers significantly expedited and enhanced nanomaterial discovery, optimization, and manufacturing.

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“…Therefore, more advanced and smart fabrication techniques with fine control over the synthesis of chiral TMOs are imperative. One possible approach reported recently by Zhu's group [23] is to employ AI robotic systems equipped with a pump-probe laser and CD spectrometer as an in situ deep-learning modulator for real-time management of chiral synthesis. This method has proved to be an efficient way for obtaining enantioselective chiral perovskite, in which it is usually difficult to observe distortions and screw-dislocations, let alone chiral separations from their enantiomers.…”

Section: Applications and Perspectivesmentioning

confidence: 99%

“…[ 10 ] However, it is worth to note that experimental evidence on such type of intrinsic chirality is still inadequate probably due to the difficulties in separation of chiral NCs based on current synthetic methods and high‐resolution imaging for confirming the distortions at atomic level. To overcome this, a possible synthetic approach based on artificial intelligence (AI) robotics [ 23 ] is suggested in Section 4.…”

Section: Chirality Theory In Tmo Nanostructuresmentioning

confidence: 99%

Chiral Transition Metal Oxides: Synthesis, Chiral Origins, and Perspectives

Wang

Miao³

et al. 2020

Advanced Materials

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to inorganic nanocrystals (NCs) whose unique physicochemical properties could be easily tuned by altering their size, shape, or ingredient, providing a powerful platform for exploring enhanced chiroptical effects, chirogenesis, and potentials in which chiral inorganic NCs could provide to interdisciplinary fields such as optical and biosensing, [2,3] chiral bioimaging, [4] and polarization-based display devices. [5] In general, chirality in inorganic NCs can be obtained from: [6,7] 1) intrinsic chirality formed by chiral crystals, lattice distortions, and defects, [8-10] 2) chiral shape with subwavelength dimensions, [11] 3) chirality transfer via chiral assembled nanostructures of achiral NCs, [5,12] and 4) chiral interactions of achiral NCs with chiral molecules [13] as depicted in Figure 1. The most famous property of chiral nanostructure is the optical activity which refers to the ability of a chiral unit to rotate the plane of plane polarized light. [14] In modern optics, this property is associated to the circular dichroism (CD) phenomenon, which concerns the absorption difference between left and right circularly polarized (LCP and RCP) light, therefore CD-based spectroscopies are generally regarded as powerful tools to detect chirality of a measured sample. With rapid development, a number of cutting-edge work concerning on chiral metal nanoparticles (NPs), chiral semiconductor NCs, chiral ceramics, and metal coordinate systems has been investigated recently. [6] Among them, chiral transition metal oxides (TMOs) are a newly discovered area attracting tremendous attentions because of their striking feature for nonstoichiometry even though great challenges on establishing systematic control over the synthesis and theoretical supports for chirality induction mechanisms still remain. Since the nature of metal-oxygen bonding in TMOs can vary from nearly ionic to covalent or metallic, the physicochemical properties of TMOs are strongly related to their outer d electrons. [15] When combined with chiral molecules, the overlap of the orbital of chiral molecules with the density of states of TMOs or formation of chiral surfaces can bring in tunable chirality for TMOs from UV-visible to near infrared region, endowing fascinating chiroptical properties. Therefore, herein, we emphasize recent progress on chiral TMOs in terms of their synthesis, CD effects, and possible mechanisms of induced optical chirality. In Section 2, theoretical background on the origin of induced chirality in TMOs nanostructures is briefly introduced. Section 3 will show recent progress of chiral TMOs with their synthetic Transition metal oxides (TMOs) consist of a series of solid materials, exhibiting a wide variety of structures with tunability and versatile physicochemical properties. Such a statement is undeniably true for chiral TMOs since the introduction of chirality brings in not only active optical activities but also geometrical anisotropy due to the symmetry-breaking effect. Although progressive investigations have been made for accu...

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Autonomous discovery of optically active chiral inorganic perovskite nanocrystals through an intelligent cloud lab

Cited by 99 publications

References 51 publications

Circular dichroism in non-chiral metal halide perovskites

Circular dichroism in non-chiral metal halide perovskites

Accelerated Development of Colloidal Nanomaterials Enabled by Modular Microfluidic Reactors: Toward Autonomous Robotic Experimentation

Chiral Transition Metal Oxides: Synthesis, Chiral Origins, and Perspectives

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