Autonomous climbing: An effective exercise mode with beneficial outcomes of aerobic exercise and resistance training

Shen, Fei; Zhao, Yu; Ding, Wubin; Liu, Kailin; Ren, Xiang-Yu; Zhang, Qiang; Yu, Jian; Hu, Yepeng; Zuo, Hui; Guo, Mingwei; Jin, Ling; Gong, Mingkai; Wu, Wei; Gu, Xuejiang; Xu, Lingyan; Yang, Fengjuan; Lü, Jian

doi:10.1016/j.lfs.2020.118786

Cited by 2 publications

(3 citation statements)

References 67 publications

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“…Muscle fiber type interacts with aging and exercise; aging has a major impact on type II fibers in terms of atrophy, and exercise induces hypertrophy to a different extent depending on fiber type [ 2 , 9 ]. As such, many researchers have scrutinized the interaction of muscle fiber type with aging and exercise.…”

Section: Discussionmentioning

confidence: 99%

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Muscle fiber type-dependence effect of exercise on genomic networks in aged mice models

Lee

Bae

et al. 2022

Aging

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Skeletal muscles are made up of various muscle fiber type including slow and fast-twitch fibers. Because each muscle fiber has its own physiological characteristics, the effects of aging and exercise vary depending on the type of muscle fiber. We used bioinformatics screening techniques such as differentially expressed gene analysis, gene ontology analysis and gene set enrichment analysis, to try to understand the genetic differences between muscle fiber types. The experiment and gene expression profiling in this study used the soleus (SOL, slow-twitch muscle) and gastrocnemius (GAS, fast-twitch muscle). According to our findings, fatty acid metabolism is significantly up-regulated in SOL compared to GAS, whereas the glucose metabolism pathway is significantly down-regulated in SOL compared to GAS. Furthermore, apoptosis and myogenesis patterns differ between SOL and GAS. SOL did not show differences in apoptosis due to the aging effect, but apoptosis in GAS was significantly up-regulated with age. Apoptosis in GAS of old groups is significantly reduced after 4 weeks of aerobic exercise, but no such finding was found in SOL. In terms of myogenesis, exercise intervention up-regulated this process in GAS of old groups but not in SOL. Taken together, muscle fiber type significantly interacts with aging and exercise. Despite the importance of the interaction between these factors, large-scale gene expression data has rarely been studied. We hope to contribute to a better understanding of the relationship between muscle fiber type, aging and exercise at the molecular level.

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Section: Discussionmentioning

confidence: 99%

“…The effect of exercise on muscle hypertrophy varies depending on the muscle fiber type. Resistance training improves the muscle mass -to-body ratio in fast-twitch muscles but not in slow-twitch muscles [ 9 ]. Moreover, exercise causes changes in the composition of muscle fiber types.…”

Section: Introductionmentioning

confidence: 99%

Muscle fiber type-dependence effect of exercise on genomic networks in aged mice models

Lee

Bae

et al. 2022

Aging

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“…Studies have shown that regular physical activity enhances exercise performance, induces increased skeletal muscle protein synthesis, inhibits skeletal muscle protein degradation (Qiu et al, 2014), improves mitochondrial function, and subsequently promotes metabolic homeostasis in the body (Shen et al, 2021). However, intensive or prolonged exercise can trigger an oxidative imbalance, which can cause oxidative damage and lead to muscle fatigue (Reid et al, 1992;O'Neill et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Integrative profiling of metabolome and transcriptome of skeletal muscle after acute exercise intervention in mice

Ye,

Liu,

Qiao

et al. 2023

Front. Physiol.

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This study aims to explore the molecular regulatory mechanisms of acute exercise in the skeletal muscle of mice. Male C57BL/6 mice were randomly assigned to the control group, and the exercise group, which were sacrificed immediately after an acute bout of exercise. The study was conducted to investigate the metabolic and transcriptional profiling in the quadriceps muscles of mice. The results demonstrated the identification of 34 differentially expressed metabolites (DEMs), with 28 upregulated and 6 downregulated, between the two groups. Metabolic pathway analysis revealed that these DEMs were primarily enriched in several, including the citrate cycle, propanoate metabolism, and lysine degradation pathways. In addition, the results showed a total of 245 differentially expressed genes (DEGs), with 155 genes upregulated and 90 genes downregulated. KEGG analysis indicated that these DEGs were mainly enriched in various pathways such as ubiquitin mediated proteolysis and FoxO signaling pathway. Furthermore, the analysis revealed significant enrichment of DEMs and DEGs in signaling pathways such as protein digestion and absorption, ferroptosis signaling pathway. In summary, the identified multiple metabolic pathways and signaling pathways were involved in the exercise-induced physiological regulation of skeletal muscle, such as the TCA cycle, oxidative phosphorylation, protein digestion and absorption, the FoxO signaling pathway, ubiquitin mediated proteolysis, ferroptosis signaling pathway, and the upregulation of KLF-15, FoxO1, MAFbx, and MuRF1 expression could play a critical role in enhancing skeletal muscle proteolysis.

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Autonomous climbing: An effective exercise mode with beneficial outcomes of aerobic exercise and resistance training

Cited by 2 publications

References 67 publications

Muscle fiber type-dependence effect of exercise on genomic networks in aged mice models

Muscle fiber type-dependence effect of exercise on genomic networks in aged mice models

Integrative profiling of metabolome and transcriptome of skeletal muscle after acute exercise intervention in mice

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