Autonomous capillary microfluidic devices with constant flow rate and temperature-controlled valving

Li, Lanhui; Westerbeek, Eiko Y.; Vollenbroek, Jeroen C.; Beer, Sissi de; Shui, Lingling; Odijk, Mathieu; Eijkel, Jan C.T.

doi:10.1039/d1sm00625h

Cited by 5 publications

(3 citation statements)

References 46 publications

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“…Recently, L. Li et al grafted thermo-responsive polymer Poly(Nisopropylacrylamide) (PNIPAm) onto PDMS. When the channel temperature increased from 20 to 37 • C, the channel surface changes from hydrophilic to hydrophobic, forming a CPCV [143]. Thus, the temperature control valve can regulate sample flow more flexibly.…”

Section: By Changing Surface Tensionmentioning

confidence: 99%

A Review of Capillary Pressure Control Valves in Microfluidics

Wang

Zhang

et al. 2021

Biosensors

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Microfluidics offer microenvironments for reagent delivery, handling, mixing, reaction, and detection, but often demand the affiliated equipment for liquid control for these functions. As a helpful tool, the capillary pressure control valve (CPCV) has become popular to avoid using affiliated equipment. Liquid can be handled in a controlled manner by using the bubble pressure effects. In this paper, we analyze and categorize the CPCVs via three determining parameters: surface tension, contact angle, and microchannel shape. Finally, a few application scenarios and impacts of CPCV are listed, which includes how CPVC simplify automation of microfluidic networks, work with other driving modes; make extensive use of microfluidics by open channel, and sampling and delivery with controlled manners. The authors hope this review will help the development and use of the CPCV in microfluidic fields in both research and industry.

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Section: By Changing Surface Tensionmentioning

confidence: 99%

A Review of Capillary Pressure Control Valves in Microfluidics

Wang

Zhang

et al. 2021

Biosensors

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“…The flow releases when the device is cooled down. 40 Also, applying geometrical changes on a surface patch can be used as a retention element. For example, a study used a micro-hole array perpendicular to the flow direction.…”

Section: Retention Elements In 3d Capillary-driven Microfluidicsmentioning

confidence: 99%

Capillary-driven microfluidics: impacts of 3D manufacturing on bioanalytical devices

Azizian

Casals‐Terré

Ricart

et al. 2023

Analyst

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“…Capillary-flow microfluidic devices are attractive for bioanalytical or clinical disease detection applications due to their small working volumes, simple operation, quick sample processing, and minimal or non-existent external power requirements. − Capillary-flow microfluidic devices are governed by capillary action, which is a rapid liquid delivery technique capable of operating without an external power source, also referred to as capillary flow . The self-driven fluid flow within these devices is influenced by surface tension, viscosity, and capillary pressure along with the microchannel geometry and surface chemistry (wettability) of the solid material.…”

Section: Introductionmentioning

confidence: 99%

Materials Characterization of Stereolithography 3D Printed Polymer to Develop a Self-Driven Microfluidic Device for Bioanalytical Applications

Stark,

Gamboa,

Esparza

et al. 2024

ACS Appl. Bio Mater.

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Stereolithography (SLA) 3D printing is a rapid prototyping technique and reproducible manufacturing platform, which makes it a useful tool to develop advanced microfluidic devices for bioanalytical applications. However, limited information exists regarding the physical, chemical, and biological properties of the photocured polymers printed with SLA. This study demonstrates the characterization of a commercially available SLA 3D printed polymer to evaluate the potential presence of any time-dependent changes in material properties that may affect its ability to produce functional, capillary-action microfluidic devices. The printed polymer was analyzed with Fourier transform infrared–attenuated total reflectance, contact angle measurements, tensile test, impact test, scanning electron microscopy, and fluid flow analysis. Polymer biocompatibility was assessed with propidium iodide flow cytometry and an MTT assay for cell viability. The material characterization and biocompatibility results were then implemented to design and fabricate a self-driven capillary action microfluidic device for future use as a bioanalytical assay. This study demonstrates temporally stable mechanical properties and biocompatibility of the SLA polymer. However, surface characterization through contact angle measurements shows the polymer’s wettability changes over time which indicates there is a limited postprinting period when the polymer can be used for capillary-based fluid flow. Overall, this study demonstrates the feasibility of implementing SLA as a high-throughput manufacturing method for capillary action microfluidic devices.

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Autonomous capillary microfluidic devices with constant flow rate and temperature-controlled valving

Abstract: In this paper, we report on a capillary microfluidic device with constant flow rate and temperature-triggered stop valve function. It contains a PDMS channel that was grafted by a thermo-responsive...

Cited by 5 publications

References 46 publications

A Review of Capillary Pressure Control Valves in Microfluidics

A Review of Capillary Pressure Control Valves in Microfluidics

Capillary-driven microfluidics: impacts of 3D manufacturing on bioanalytical devices

Materials Characterization of Stereolithography 3D Printed Polymer to Develop a Self-Driven Microfluidic Device for Bioanalytical Applications

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