Autonomous Bionanorobots via a Cage-Shaped Silsesquioxane Vehicle for In Vivo Heavy Metal Detoxification

Abstract

Nanorobots hold great promise for integrated drug delivery systems that are responsive to molecular triggers. Herein, we successfully developed an automatic smart bionanorobot that has transport capability and recognizes and removes zinc ions from poisoned cells based on nanoscale polyhedral oligomeric silsesquioxane molecules. This intelligent bionanorobot can easily move inside and outside the cell and find zinc ions owing to its highly selective recognition to zinc ions and high cell permeability, especially the well-combined high penetration and strong binding energy. More importantly, it was also found that this intelligent bionanorobot can restore round HeLa cells to a normal fusiform cell morphology following high-concentration zinc treatment and does not interfere with cell proliferation and division. It was also shown by in vivo experiments that the bionanorobot can inhibit persistent enlargement of the liver caused by zinc ion poisoning.

Regulating Type H Vessel Formation and Bone Metabolism via Bone‐Targeting Oral Micro/Nano‐Hydrogel Microspheres to Prevent Bone Loss

“…POSS-SH and acryloyl chloride-modified polyethylene glycol 400 (PEG-Ac) have been synthesized in the laboratory. [32] Synthesis of PDAP NPs: 0.363 mg of PEG-Ac (0.8 mmol), 0.015 g of 2,2-dimethoxy-2-phenylacetophenone (DMPA) (0.06 mmol), and 2.032 g of POSS-SH (0.2 mmol) were added into 20.0 mL of THF to react for 2.5 h under 365 nm UV light with N 2 protection at room temperature. Then, this reaction solution was mixed with 10.00 mL of THF containing 0.1200 g of DMPA (0.47 mmol), 0.0970 g of Asp8-Ac (0.1 mmol), and 0.0320 g of DFO-Ac (0.05 mmol) and continued to react for 8 h (Figure S14, Supporting Information).…”

Visualizable and Lubricating Hydrogel Microspheres Via NanoPOSS for Cartilage Regeneration

“…This result is attributed to the POSS skeleton, which is beneficial to cell adhesion and detachment while improving the mechanical rigidity of the cell structure. [ 12 ] The failure of MHS@PPKHF group to significantly promote cell proliferation may be because the microsphere co‐culture time with cells is too short to degrade and release effective drug concentration during this period. In general, the above results indicate that the materials used in this study have good biocompatibility with BMSCs and can effectively promote cell proliferation.…”

“…[11] POSS is widely used in biomaterials because of its unique Si-O-Si framework and the nature of nano-hard materials that can be easily taken up by cells. [12] Han et al introduced OV-POSS into hydrogels, forming well-dispersed nanocomposites with precisely size-controlled hard blocks within it and increasing the crosslinking density to improve mechanical properties for repairing osteochondral defects. [13] From drug delivery to bioimaging, the distinctive advantages of POSS: easy functionalization, chemical stability, and biocompatibility have allowed researchers to develop better drug delivery systems and contrast imaging platforms.…”

“…[ 11 ] POSS is widely used in biomaterials because of its unique SiOSi framework and the nature of nano‐hard materials that can be easily taken up by cells. [ 12 ] Han et al. introduced OV‐POSS into hydrogels, forming well‐dispersed nanocomposites with precisely size‐controlled hard blocks within it and increasing the crosslinking density to improve mechanical properties for repairing osteochondral defects.…”

POSS Engineering of Multifunctional Nanoplatforms for Chemo-Mild Photothermal Synergistic Therapy

“…Consequently, incorporating POSS can mitigate the aggregation caused by π-π stacking interactions between molecules. Furthermore, based on our previous research conducted in our laboratory [51,52], we discovered that introducing PEG could effectively enhance water solubility and achieve amphipathy for POSS-based nanoparticles, thereby significantly improving cell permeability and the biocompatibility of these nanoplatforms while simultaneously enhancing their potential applications in biological imaging [53], drug delivery [54,55], and tissue regeneration [56].…”