Autonomic Regulation of Nociceptive and Immunologic Changes in a Mouse Model of Complex Regional Pain Syndrome

Sahbaie, Peyman; Li, Wenwu; Guo, Tian-Zhi; Shi, Xiaoshuang; Kingery, Wade S.; Clark, J. David

doi:10.1016/j.jpain.2021.09.009

Cited by 12 publications

(11 citation statements)

References 58 publications

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“…In addition, mice treated with IgG from patients with CRPS manifested cellular changes such as microglia and astrocyte activation at the dorsal horn as well as pain regions in the brain [ 25 ]. The findings were supported by a recent study by Sahbaie and colleagues [ 26 ]. Passive transfer of serum from mice with induced fracture containing autoantibodies against the autonomic nervous system receptors and the role in pain processing were interestingly presented.…”

Section: Complex Regional Pain Syndrome (Crps)supporting

confidence: 86%

Autoimmune Autonomic Dysfunction Syndromes: Potential Involvement and Pathophysiology Related to Complex Regional Pain Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Silicone Breast Implant–Related Symptoms and Post-COVID Syndrome

Mahroum

Shoenfeld

2022

Pathophysiology

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The pathophysiological mechanisms involved in chronic disorders such as complex regional pain syndrome, fibromyalgia, chronic fatigue syndrome, silicone breast implant–related symptoms, and post-COVID syndrome have not been clearly defined. The course of the pain in some of the syndromes, the absence of evident tissue damage, and the predominance of alterations in the autonomic nervous system are shared similarities between them. The production of autoantibodies following a trigger in the syndromes was previously described, for instance, trauma in complex regional pain syndrome, infectious agents in fibromyalgia, chronic fatigue syndrome, and post-COVID syndrome, and the immune stimulation by silicone in women with breast implants. In fact, the autoantibodies produced were shown to be directed against the autonomic nervous system receptors, leading to the amplification of the perception of pain alongside various clinical symptoms seen during the clinical course of the syndromes. Therefore, we viewed autoantibodies targeting the autonomic nervous system resulting in autonomic dysfunction as likely the most comprehensive explanation of the pathophysiology of the disorders mentioned. Based on this, we aimed to introduce a new concept uniting complex regional pain syndrome, fibromyalgia, chronic fatigue syndrome, silicone breast implant–related symptoms, and post-COVID syndrome, namely “autoimmune autonomic dysfunction syndromes”. Due to its etiological, pathophysiological, and clinical implications, the suggested term would be more precise in classifying the syndromes under one title. The new title would doubtlessly facilitate both laboratory and clinical studies aimed to improve diagnosis and make treatment options more directed and precise.

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Section: Complex Regional Pain Syndrome (Crps)supporting

confidence: 86%

Autoimmune Autonomic Dysfunction Syndromes: Potential Involvement and Pathophysiology Related to Complex Regional Pain Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Silicone Breast Implant–Related Symptoms and Post-COVID Syndrome

Mahroum

Shoenfeld

2022

Pathophysiology

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“…The potential for trauma patients to develop chronic pain is significant, but the etiology of what predisposes a patient to the conversion from acute to chronic pain is unclear [3,56]. There are multiple contributors directly related to the trauma that increase the risk: nerve damage, tissue and muscle injury, innate immunological, and neuro-inflammatory responses [57]. However, there are additional modifiable and nonmodifiable risk factors such as: (1) phenotypic and social characteristics including age, gender, ethnicity, psychological distress, psychosocial stressors, socioeconomics, prior chronic pain, alcohol, and marijuana abuse, and illicit drug use [3] and; (2) genomic characteristics including but not limited to epigenetics, transcriptomics, proteomics, metabolomics, microbiome, and endogenous opioid systems [58][59][60][61].…”

Section: Risk Of Conversion From Acute To Chronic Painmentioning

confidence: 99%

Regional anesthesia and analgesia for trauma: an updated review

Torrie¹

2022

Current Opinion in Anaesthesiology

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Purpose of reviewThis narrative review is an updated summary of the value of regional anesthesia and analgesia for trauma and the special considerations when optimizing pain management and utilizing regional analgesia for acute traumatic pain. Recent findingsIn the setting of the opioid epidemic, the need for multimodal analgesia in trauma is imperative. It has been proposed that inadequately treated acute pain predisposes a patient to increased risk of developing chronic pain and continued opioid use. Enhanced Regional Anesthesia techniques along with multimodal pain therapies is thought to reduce the stress response and improve patient's short-and long-term outcomes.

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“…Exploring this potential is very important, so it will be able to have selling power to increase the economic capacity of an area where one of the ways is to open up investment opportunities. Because investment can produce good side effects for the area on an ongoing basis (Elavarasan et al, 2021;Sahbaie et al, 2022;Widiani, 2021).…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Implementing Organizations in the Implementation of Investment Policy (Case study in Garut Regency)

Widaningsih

Natision

Ungkari

et al. 2023

ijjm

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The Endowment Development Strategy paradigm is one of the keys to success in carrying out development in our country. In the principles of the Endowment Development Strategy, one way to market the regional economic power is by opening up investment opportunities. However, the reality that has occurred regarding the development of investment in various regions (especially in Garut Regency) is still very far from expectations, where investment interest with investment realization is still far from the targeted figure. As for the purpose of this research is to find objective facts in the hope that the results of the research can be accepted as the truth. The research method used is a qualitative approach method with the object of institutional research, as well as the unit of analysis in this research is the DPMPT and other related Technical Services. The data analysis technique uses the triangulation method by synchronizing the data obtained among one informant and other informants. The results of the study show that existing SOPs at other Technical Services have not been integrated into the DPMPT so that they are still implemented partially. Based on field results there are still problems related to delays in issuing permits, this shows that the principle of excellent service, service that is fast, precise, certain, efficient and effective in accordance with the principles of good governance have not been maximized. The characteristics of implementing organizations in Garut Regency are still relatively weak, this is indicated by the unpreparedness of the human resources of the policy implementer, this is proved by the lack of understanding of the main tasks and functions (TUPOKSI) as well as Standards and the objectives of the policy itself. Based on this research, it is suggested that the implementing apparatus in the field should be involved in technical meetings in the context of integrated licensing services in order to understand the real purpose of the integrated licensing services policy. Building good and effective communication so that policy implementers have the courage to ask superiors about things they do not understand, especially about the objectives of the policies being implemented, the leaders must display a more responsive attitude, not arrogant and not authoritarian.

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Autonomic Regulation of Nociceptive and Immunologic Changes in a Mouse Model of Complex Regional Pain Syndrome

Cited by 12 publications

References 58 publications

Autoimmune Autonomic Dysfunction Syndromes: Potential Involvement and Pathophysiology Related to Complex Regional Pain Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Silicone Breast Implant–Related Symptoms and Post-COVID Syndrome

Autoimmune Autonomic Dysfunction Syndromes: Potential Involvement and Pathophysiology Related to Complex Regional Pain Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Silicone Breast Implant–Related Symptoms and Post-COVID Syndrome

Regional anesthesia and analgesia for trauma: an updated review

Characteristics of Implementing Organizations in the Implementation of Investment Policy (Case study in Garut Regency)

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