Autonomic Receptor Function in the Lower Urinary Tract of Man and Cat

Nergårdh, Arne; Boréus, L. O.

doi:10.3109/00365597209132077

Cited by 123 publications

(43 citation statements)

References 14 publications

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“…The function of sympathetic innervation is opposite to that of parasympathetic innervation. The release of sympathetic neurotransmitter noradrenalin causes that the detrusor is blocked by inhibitory β-adrenergic receptors and both the bladder neck and the smooth-muscular urethra are tonicized by excitatory detrusor α-adrenergic receptors, thus achieving continence (Nergardh and Boreus 1972, Edvardsen and Setekleiv 1968, Salimi et al 1969, Raezer et al 1973, Awad et al 1974, Levin and Wein 1979. Therefore, the observed increase in the number of adrenergic nerve fibers could be a factor which additionally decreases the spasticity of the overreactive bladder and for that reason improves the treatment.…”

Section: H/npymentioning

confidence: 99%

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

Lepiarczyk¹,

Bossowska²,

Kaleczyc³

et al. 2011

Polish Journal of Veterinary Sciences

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Botulinum toxin (BTX) belongs to a family of neurotoxins which strongly influence the function of autonomic neurons supplying the urinary bladder. Accordingly, BTX has been used as an effective drug in experimental therapies of a range of neurogenic bladder disorders. However, there is no detailed information dealing with the influence of BTX on the morphological and chemical properties of nerve fibres supplying the urinary bladder wall. Therefore, the present study investigated, using double-labeling immunohistochemistry, the distribution, relative frequency and chemical coding of cholinergic and noradrenergic nerve fibers supplying the wall of the urinary bladder in normal female pigs (n=6) and in the pigs (n=6) after intravesical BTX injections. In the pigs injected with BTX, the number of adrenergic (DβH-positive) nerve fibers distributed in the bladder wall (urothelium, submucosa and muscle coat) was distinctly higher while the number of cholinergic (VAChT-positive) nerve terminals was lower than that found in the control animals. Moreover, the injections of BTX resulted in some changes dealing with the chemical coding of the adrenergic nerve fibers. In contrast to the normal pigs, in BTX injected animals the number of DβH/NPY-or DβH/CGRP-positive axons was higher in the muscle coat, and some fibres distributed in the urothelium and submucosa expressed immunoreactivity to CGRP. The results obtained suggest that the therapeutic effects of BTX on the urinary bladder might be dependent on changes in the distribution and chemical coding of nerve fibers supplying this organ.

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Section: H/npymentioning

confidence: 99%

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

Lepiarczyk¹,

Bossowska²,

Kaleczyc³

et al. 2011

Polish Journal of Veterinary Sciences

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“…Some evidence concerning the distribution of axand ,B-adrenoceptors in urinary bladder has been obtained in single-dose studies on strips from urinary bladder of experimental animals (Edmunds & Roth, 1920;Young & Macht, 1923;Edvardsen & Setekleiv, 1-968;Salimi, Setekleiv & Skobba, 1969;Malin & Boyarsky, 1970;Rohner, Raezer, Wein & Schoenberg, 1971;Nergardh & Boreus, 1972) and of man (Wesson, 1920;Young & Macht, 1923;Coupar & Turner, 1969;Todd & Mack, 1969;Nergardh & Boreus, 1972). Few studies, however, have compared detrusor and bladder neck in man (Young & Macht, 1923;Nergardh & Boreus, 1972).…”

Section: Introductionmentioning

confidence: 99%

Distribution of Α‐ and Β‐adrenoceptors in Human Urinary Bladder

Awad

Bruce

Carro-Ciampi

et al. 1974

British J Pharmacology

131

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The distribution of α‐ and β‐adrenoceptors in isolated preparations of human bladder neck and detrusor muscle has been studied. Adrenaline caused contraction of the bladder neck which was blocked by phenoxybenzamine but unaltered by propranolol. Isoprenaline caused relaxation of the bladder neck which was blocked by propranolol. High concentrations caused contraction which was enhanced by propranolol but blocked by phenoxybenzamine. Detrusor muscle was relaxed by isoprenaline and this effect was blocked by propranolol. Phenylephrine caused relaxation of detrusor which was unaffected by phenoxybenzamine; in some cases contraction was produced in the presence of propranolol. It is concluded that the bladder neck contains mainly α‐receptors and the detrusor mainly β‐receptors but both regions possess both types of adrenoceptor.

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“…Such an operation should, therefore, not be considered before the 3rd or 4th month post-injury. As an alternative to surgery it is worthwhile trying a medical treatment with alpha-adrenergic blocking agents such as phenoxybenzamine since adrenergic ganglion cells and fibres have been described in the bladder neck and proximal urethra of different mammalian species, as well as in humans (Nergardh & Boreus, 1972;Caine, Raz & Zeigler, FIG. 3 Voiding cysto-urethrogram showing the various points of reference measured in our urodynamic studies.…”

Section: Diagnosis and Treatment Past The Acute Post-traumatic Periodmentioning

confidence: 99%

From intermittent catheterisation to catheter freedom via urodynamics: a tribute to Sir Ludwig Guttmann

Rossier

Fam

1979

Spinal Cord

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Autonomic Receptor Function in the Lower Urinary Tract of Man and Cat

Cited by 123 publications

References 14 publications

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

Distribution of Α‐ and Β‐adrenoceptors in Human Urinary Bladder

From intermittent catheterisation to catheter freedom via urodynamics: a tribute to Sir Ludwig Guttmann

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