1999
DOI: 10.1111/j.1572-0241.1999.01000.x
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Autonomic Nervous System Tone Measured by Baroreflex Sensitivity Is Depressed in Patients With End-Stage Liver Disease

Abstract: Vagal tone, as assessed by BRS, is markedly depressed in cirrhotic patients awaiting liver transplantation.

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Cited by 26 publications
(11 citation statements)
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“…A study using the phenylephrine method did not show significant differences between cirrhotic patients (Child class B and C) and healthy subjects (26). In contrast, Barron et al (27) recently demontrated that BRS (evaluated by means of phenylephrine infusion) is markedly depressed in cirrhotics awaiting liver transplantation. Further interest has centered on the possible prognostic implications of autonomic dysfunction in cirrhosis.…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…A study using the phenylephrine method did not show significant differences between cirrhotic patients (Child class B and C) and healthy subjects (26). In contrast, Barron et al (27) recently demontrated that BRS (evaluated by means of phenylephrine infusion) is markedly depressed in cirrhotics awaiting liver transplantation. Further interest has centered on the possible prognostic implications of autonomic dysfunction in cirrhosis.…”
Section: Discussionmentioning
confidence: 93%
“…A mouse monoclonal antibody directed against human uPAR was kindly provided by Dr. K. Dan0 (Finsen Lab., Copenhagen, Denmark) (27). Anti-CD68 monoclonal antibody (clone PG-M1) was purchased from DAKO (Copenhagen, Denmark).…”
Section: Anti Bodiesmentioning
confidence: 99%
“…Autonomic dysfunction has previously been described in patients with chronic liver disease of diverse aetiologies [27,[30][31][32]. The conventional view to date has been that the development of autonomic dysfunction in such patients is largely a consequence of the development of cirrhosis, rather than a feature of the individual underlying liver disease [46].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, fatigue is reported as a problem by the majority of patients with conditions characterized by abnormalities of blood pressure control such as primary autonomic failure [23]. Furthermore, autonomic dysfunction [identified as abnormality in autonomic function testing, impaired baroreflex sensitivity (BRS), or abnormality in blood pressure homeostasis] has been identified as an independent risk factor for cardiovascular mortality (particularly sudden cardiac death) in nonliver diseases [24][25][26] and has been found at increased prevalence in patients with chronic liver diseases including PBC [27][28][29][30][31][32][33][34][35].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, these patients have an attenuated vasoconstrictor response from volume receptors as the result of an overproduction of vasoactive agents 22 and an autonomic nervous system dysfunction. 23,24 As a consequence, patients in end-stage liver disease have a defective response to volemic changes. Therefore, we thought it would be of interest to propose a circuit alleviating volemic modifications by uncoupling the ex vivo liver perfusion from the systemic circulation.…”
Section: Discussionmentioning
confidence: 99%